Searched for: subject:"Disease%5C+activity"
(1 - 18 of 18)
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Abe, N. (author), Kato, S. (author), Tsuchida, T. (author), Sugimoto, K. (author), Saito, R. (author), Verschuren, L. (author), Kleemann, R. (author), Oka, K. (author)
Non-alcoholic steatohepatitis (NASH) is a fast-growing liver disease in the Western world. Currently, only a few animal models show both the metabolic and histological features of human NASH. We aimed to explore murine NASH models in a time dependent manner that exhibit metabolic, histological and transcriptomic hallmarks of human NASH. For this...
article 2019
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Fieten, K.B. (author), Zijlstra, W.T. (author), van Os-Medendorp, H. (author), Meijer, Y. (author), Venema, M.U. (author), Rijssenbeek-Nouwens, L. (author), l' Hoir, M.P. (author), Bruijnzeel-Koomen, C.A. (author), Pasmans, S.G.M.A. (author)
Background: About 10 to 20% of children in West European countries have atopic dermatitis (AD), often as part of the atopic syndrome. The full atopic syndrome also consists of allergic asthma, allergic rhinitis and food allergy. Treatment approaches for atopic dermatitis and asthma include intermittent anti-inflammatory therapy with...
article 2014
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Tchetverikov, I. (author), Kraan, M.C. (author), van El, B. (author), Hanemaaijer, R. (author), de Groot, J. (author), Huizinga, T.W.J. (author)
Objective: To analyse the effects of leflunomide and methotrexate treatment on matrix metalloproteinase (MMP) activity levels in a2 macroglobulin/MMP (α2M/MMP) complexes in the systemic circulation of rheumatoid arthritis (RA) patients. Methods: A total of 102 RA patients from a prospective, double-blind, randomised clinical trial comparing...
article 2008
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Intema, F. (author), de Groot, J. (author), Elshof, B. (author), Vianen, M.E. (author), Yocum, S. (author), Zuurmond, A. (author), Mastbergen, S.C. (author), Lafeber, F.P. (author), TNO Kwaliteit van Leven (author)
In studies aimed at local treatment of experimental osteoarthritis (OA) it is optimal to have an internal (untreated) OA control. Such an approach excludes interanimal variation, and allows paired statistical evaluation of treatment efficacy. For this purpose, we developed and characterized a bilateral version of the canine Groove model. We...
article 2008
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Rieckmann, P. (author), Kruse, N. (author), Nagelkerken, L. (author), Beckmann, K. (author), Miller, D. (author), Polman, C. (author), Dahlke, F. (author), Toyka, K.V. (author), Hartung, H.P. (author), Stürzebecher, S. (author), TNO Preventie en Gezondheid (author)
Background: Subcutaneous IFNβ-1b (Betaferon®) is an established immunomodulatory treatment for relapsing remitting MS and active secondary progressive multiple sclerosis (SPMS). It modulates cytokine and adhesion molecule expression but long term in vivo effects of IFNβ-1b on the immune system are not known in multiple sclerosis. Objective: To...
article 2005
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Verschuren, L. (author), Kleemann, R. (author), Offerman, E.H. (author), Szalai, A.J. (author), Emeis, S.J. (author), Princen, H.M.G. (author), Kooistra, T. (author), TNO Kwaliteit van Leven (author)
Objective - To evaluate whether low-dose atorvastatin suppresses atherosclerotic lesion progression and inflammation in apolipoprotein E*3 (apoE*3)-Leiden mice beyond its cholesterol-lowering effect. Methods and Results - ApoE*3-Leiden mice were fed a high-cholesterol (HC) diet until mild atherosclerotic lesions had formed. Subsequently, HC diet...
article 2005
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Dekkers, J.C. (author), Geenen, R. (author), Godaert, G.L.R. (author), Bijlsma, J.W.J. (author), van Doornen, L.J.P. (author), TNO Arbeid (author)
Objective. To investigate sympathetic (SNS) and parasympathetic (PNS) nervous system activity in patients with recently diagnosed rheumatoid arthritis (RA), and to analyze the association between activity of these systems and disease activity, and complaints that frequently occur in RA, viz., pain, fatigue, negative mood, and stiffness. Methods....
article 2004
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Vogt, M.H.J. (author), Floris, S. (author), Killestein, J. (author), Knol, D.L. (author), Smits, M. (author), Barkhof, F. (author), Polman, C.H. (author), Nagelkerken, L. (author)
Osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN plasma levels were elevated in active relapsing-remitting (RR) MS patients. In this longitudinal study, a trend was observed for OPN serum levels in relation to clinical...
article 2004
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Landewé, R. (author), Geusens, P. (author), Boers, M. (author), van der Heijde, D. (author), Lems, W. (author), te Koppele, J. (author), van der Linden, S. (author), Garnero, P. (author), TNO Preventie en Gezondheid (author)
Objective. To investigate in a randomized clinical trial setting with an aggressive combination-therapy arm and a mild-monotherapy arm, whether therapy-induced changes in urinary C-terminal crosslinking telopeptide of type I collagen (CTX-I) and type II collagen (CTX-II) predict 5-year radiographic progression in patients with rheumatoid...
article 2004
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Boonen, A. (author), van der Heijde, D. (author), Landewé, R. (author), Chorus, A. (author), van Lankveld, W. (author), Miedema, H. (author), van der Tempel, H. (author), van der Linden, S. (author), TNO Preventie en Gezondheid (author)
Objective: To determine whether avoidant coping in ankylosing spondylitis (AS) is independent of disease status and whether it is stable over time. Methods: 658 patients with AS completed a postal questionnaire on health status, including pain and stiffness (BASDAI), physical function (BASFI), and coping (CORS). In CORS, "decreasing activities...
article 2004
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Lopatinskaya, L. (author), Boxel van-Dezaire, A.H.H. (author), Barkhof, F. (author), Polman, C.H. (author), Lucas, C.J. (author), Nagelkerken, L. (author)
In this longitudinal study, we examined the expression of Fas, FasL, CCR3, CCR5 and CXCR3 mRNA in peripheral blood mononuclear cells (PBMCs) of secondary progressive (SP) and relapsing-remitting (RR) multiple sclerosis (MS) patients. In RR patients, FasL, CCR3 and CCR5 mRNA levels were increased prior to the exacerbations, but these decreased...
article 2003
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Tchetverikov, I. (author), Verzijl, N. (author), Huizinga, T.W.J. (author), TeKoppele, J.M. (author), Hanemaaijer, R. (author), de Groot, J. (author)
Objective. The aim of the present study was to analyze α2Macroglobulin/MMP (α2M/MMP) complex formation and to investigate whether MMP activity in α2M/MMP complexes in serum can be used as a disease marker in rheumatoid arthritis (RA). Methods. High and low molecular weight (H/LMW) substrates and inhibitors and size exclusion were used to analyze...
article 2003
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Tchetverikov, I. (author), Lard, L.R. (author), de Groot, J. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Breedveld, F.C. (author), Huizinga, T.W.J. (author), Hanemaaijer, R. (author), TNO Preventie en Gezondheid (author)
Objective: To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in α2 macroglobulin (α2M)/MMP complexes and the progression of joint destruction in patients with recent onset rheumatoid arthritis (RA). Methods: 109 patients with RA of recent onset were entered into this longitudinal...
article 2003
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Vogt, M.H.J. (author), Lopatinskaya, L. (author), Smits, M. (author), Polman, C.H. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing-remitting MS patients. In contrast, OPN protein levels...
article 2003
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van Tubergen, A. (author), Coenen, J. (author), Landewé, R. (author), Spoorenberg, A. (author), Chorus, A. (author), Boonen, A. (author), van der Linden, S. (author), van der Heijde, D. (author), TNO Preventie en Gezondheid (author)
Objectives. To investigate whether the single-item fatigue question of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Multidimensional Fatigue Inventory (MFI) are appropriate instruments to measure fatigue in ankylosing spondylitis (AS); to identify factors that influence fatigue in AS; and to assess how fatigue in all...
article 2002
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Chorus, A.M.J. (author), Boonen, A. (author), Miedema, H.S. (author), van der Linden, S. (author)
Objectives: To assess the labour market position of patients with ankylosing spondylitis (AS) in relation to disease duration and to identify potential factors in relation to withdrawal from the labour force. Methods: A cross sectional mail survey was conducted among 658 patients with AS. Participation in the labour force was defined as having a...
article 2002
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van der Laan, W. (author), Molenaar, E. (author), Ronday, K. (author), Verheijen, J. (author), Breedveld, F. (author), Greenwald, R. (author), Dijkmans, B. (author), Tekoppele, J. (author), Gaubius instituut TNO (author)
Objective. To investigate the effects of doxycycline on disease activity and joint destruction in patients with rheumatoid arthritis (RA). Methods. A 36 week double blind, placebo controlled crossover trial was conducted. Patients (n = 66) received 50 mg doxycycline or placebo twice a day during 12, 24, or 36 weeks. Patient assessments were...
article 2001
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't Hart, B.A. (author), Bank, R.A. (author), de Roos, J.A.D.M. (author), Brok, H. (author), Jonker, M. (author), Theuns, H.M. (author), Hakimi, J. (author), Koppele, J.M.Te. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The objective of this study was to analyse parameters in rhesus monkey collagen-induced arthritis (CIA) with which the inflammation and destruction of the joints can be described in quantitative terms. CIA was induced in genetically susceptible and resistant monkeys, which can be distinguished on the basis of the dominant resistance marker Mamu...
article 1998
Searched for: subject:"Disease%5C+activity"
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