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How feelings of unpleasantness develop during the progression of motion sickness symptoms

Reuten, A.J.C. (author), Nooij, S.A.E. (author), Bos, J.E. (author), Smeets, J.B.J. (author)

To mitigate motion sickness in self-driving cars and virtual reality, one should be able to quantify its progression unambiguously. Self-report rating scales either focus on general feelings of unpleasantness or specific symptomatology. Although one generally feels worse as symptoms progress, there is anecdotal evidence suggesting a non...

article 2021

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Silicon for prevention, cure and care: A technology toolbox of wearables at the dawn of a new health system

van Hoof, C. (author), van den Brand, J. (author), de Smet, J. (author), Grieten, L. (author), De Francisco, R. (author)

Our increasing life expectancy also implies that many of us will be suffering from one or more chronic illnesses during a larger part of our lives. Medical-grade wearables have the grand promise and the largely untapped potential to become a cornerstone technology in the care cycle. For chronic patients, tools are needed that improve the risk...

conference paper 2016

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Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis

Oranje, A.P. (author), Verbeek, R. (author), Verzaal, P. (author), Haspels, I. (author), Prens, E. (author), Nagelkerken, L. (author), TNO Kwaliteit van Leven (author)

Background: Wet-wrap treatment (WWT) with diluted topical steroids is widely used in atopic dermatitis (AD). Mice with transgenic overexpression of human apolipoprotein C1 (APOC1) in the liver and the skin are not only characterized by hyperlipidaemia and raised IgE levels, but also by pruritic dermatitis and a disturbed skin barrier function,...

article 2009

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A dynamic population-based model for the development of work-related respiratory health effects among bakery workers

Warren, N. (author), Meijster, T. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)

Objectives: This paper presents a dynamic population-based model for the development of sensitisation and respiratory symptoms in bakery workers. The model simulates a population of individual workers longitudinally and tracks the development of work-related sensitisation and respiratory symptoms in each worker. Methods: The model has three...

article 2009

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Does loading influence the severity of cartilage degeneration in the canine groove-model of OA?

Vos, P. (author), Intema, F. (author), van El, B. (author), de Groot, J. (author), Bijlsma, J.W.J. (author), Lafeber, F. (author), Mastbergen, S. (author), TNO Kwaliteit van Leven (author)

Many animal models are used to study osteoarthritis (OA). In these models the role of joint loading in the development of OA is not fully understood. We studied the effect of loading on the development of OA in the canine Groove-model. In ten female beagle dogs OA was induced in one knee according to the Groove-model. The animals were divided in...

article 2009

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Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134

Nolte-'t Hoen, E.N.M. (author), Boot, E.P.J. (author), Wagenaar-Hilbers, J.P.A. (author), van Bilsen, J.H.M. (author), Arkesteijn, G.J.A. (author), Storm, G. (author), Everse, L.A. (author), van Eden, W. (author), Wauben, M.H.M. (author), TNO Kwaliteit van Leven (author)

Major problems in the analysis of CD4+ effector cell and regulatory T cell (Treg) populations in an activated immune system are caused by the facts that both cell types can express CD25 and that the discriminatory marker forkhead box p3 can only be analyzed in nonviable (permeabilized) cells. Here, we show that CD134 (OX40) can be used as a...

article 2008

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Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes

Spijkerman, A.M.W. (author), Gall, M.A. (author), Tarnow, L. (author), Twisk, J.W.R. (author), Lauritzen, E. (author), Lund-Andersen, H. (author), Emeis, J. (author), Parving, H.H. (author), Stehouwer, C.D.A. (author), TNO Kwaliteit van Leven (author)

Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after...

article 2007

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Interferon-β therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis

Zafranskaya, M. (author), Oschmann, P. (author), Engel, R. (author), Weishaupt, A. (author), van Noort, J.M. (author), Jomaa, H. (author), Eberl, M. (author), TNO Kwaliteit van Leven (author)

Therapy with interferon-β (IFN-β) has well-established clinical effects in multiple sclerosis (MS), albeit the immunomodulatory mechanisms are not fully understood. We assessed the prevalence and functional capacity of CD4+ and CD8+ T cells in healthy donors, and in untreated and IFN-β-treated MS patients, in response to myelin oligodendrocyte...

article 2007

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Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life

TNO Kwaliteit van Leven (author), Alkemade, F.E. (author), de Gittenberger-Groot, A.C. (author), Schiel, A.E. (author), van Munsteren, J.C. (author), Hogers, B. (author), van Vliet, L.S.J. (author), Poelmann, R.E. (author), Havekes, L.M. (author), van Dijk, K.W. (author), de Ruiter, M.C. (author)

OBJECTIVE - Maternal hypercholesterolemia is associated with a higher incidence and faster progression of atherosclerotic lesions in neonatal offspring. We aimed to determine whether an in utero environment exposing a fetus to maternal hypercholesterolemia and associated risk factors can prime the murine vessel wall to accelerated development of...

article 2007

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Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model

TNO Kwaliteit van Leven (author), Hassane, S. (author), Claij, N. (author), Lantinga-van Leeuwen, I.S. (author), van Munsteren, J.C. (author), van Lent, N. (author), Hanemaaijer, R. (author), Breuning, M.H. (author), Peters, D.J.M. (author), de Ruiter, M.C. (author)

OBJECTIVE - Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a multi-system disorder characterized by progressive cyst formation in the kidneys. Serious complications of ADPKD are intracranial and aortic aneurysms. The condition is mainly caused by mutations in the PKD1 or PKD2 gene. We have carefully analyzed vascular remodeling in...

article 2007

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Prognostic factors for duration of sick leave in patients sick listed with acute low back pain: A systematic review of the literature

Steenstra, I.A. (author), Verbeek, J.H. (author), Heymans, M.W. (author), Bongers, P.M. (author), TNO Kwaliteit van Leven (author)

Background: The percentages of patients with acute low back pain (LBP) that go on to a chronic state varies between studies from 2% to 34%. In some of these cases low back pain leads to great costs. Aims: To evaluate the evidence for prognostic factors for return to work among workers sick listed with acute LBP. Methods: Systematic literature...

article 2005

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Systems biology, connectivity and the future of medicine

van der Greef, J. (author), TNO Kwaliteit van Leven (author)

The concept of systems-based strategies in medicine is emerging, with systems pathology guiding an understanding of the multidimensional aspects of disease system fingerprints and systems pharmacology providing insight into dynamic system responses upon (multiple) drug perturbations. Knowledge of the changes of system characteristics during...

article 2005

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An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men

Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)

In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...

article 2004

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Osteopontin levels and increased disease activity in relapsing-remitting multiple sclerosis patients

Vogt, M.H.J. (author), Floris, S. (author), Killestein, J. (author), Knol, D.L. (author), Smits, M. (author), Barkhof, F. (author), Polman, C.H. (author), Nagelkerken, L. (author)

Osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN plasma levels were elevated in active relapsing-remitting (RR) MS patients. In this longitudinal study, a trend was observed for OPN serum levels in relation to clinical...

article 2004

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Markers for Type II Collagen Breakdown Predict the Effect of Disease-Modifying Treatment on Long-Term Radiographic Progression in Patients with Rheumatoid Arthritis

TNO Preventie en Gezondheid (author), Landewé, R. (author), Geusens, P. (author), Boers, M. (author), van der Heijde, D. (author), Lems, W. (author), te Koppele, J. (author), van der Linden, S. (author), Garnero, P. (author)

Objective. To investigate in a randomized clinical trial setting with an aggressive combination-therapy arm and a mild-monotherapy arm, whether therapy-induced changes in urinary C-terminal crosslinking telopeptide of type I collagen (CTX-I) and type II collagen (CTX-II) predict 5-year radiographic progression in patients with rheumatoid...

article 2004

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Active MMPs captured by alpha2Macroglobulin as a marker of disease activity in rheumatoid arthritis

PG (author), Tchetverikov, I. (author), Verzijl, N. (author), Huizinga, T.W.J. (author), TeKoppele, J.M. (author), Hanemaaijer, R. (author), de Groot, J. (author)

Objective. The aim of the present study was to analyze alpha2Macroglobulin/MMP (alpha2M/MMP) complex formation and to investigate whether MMP activity in alpha2M/MMP complexes in serum can be used as a disease marker in rheumatoid arthritis (RA). Methods. High and low molecular weight (H/LMW) substrates and inhibitors and size exclusion were...

article 2003

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Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis

TNO Preventie en Gezondheid (author), Tchetverikov, I. (author), Lard, L.R. (author), de Groot, J. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Breedveld, F.C. (author), Huizinga, T.W.J. (author), Hanemaaijer, R. (author)

Objective: To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in α2 macroglobulin (α2M)/MMP complexes and the progression of joint destruction in patients with recent onset rheumatoid arthritis (RA). Methods: 109 patients with RA of recent onset were entered into this longitudinal...

article 2003

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Inhibition of accelerated atherosclerosis in vein grafts by placement of external stent in ApoE*3-Leiden transgenic mice

Lardenoye, J.H.P. (author), de Vries, M.R. (author), Grimbergen, J.M. (author), Havekes, L.M. (author), Knaapen, M.W.M. (author), Kockx, M.M. (author), van Hinsbergh, V.W.M. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), Gaubius Instituut TNO (author)

Objective - Vein grafts fail because of the development of intimal hyperplasia and accelerated atherosclerosis. Placement of an external stent around vein grafts resulted in an inhibition of intimal hyperplasia in several animal studies. Here, we assess the effects of external stenting on accelerated atherosclerosis in early vein grafts in...

article 2002

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Expression of macrophage migration inhibitory factor in different stages of human atherosclerosis

Burger-Kentischer, A. (author), Goebel, H. (author), Seiler, R. (author), Fraedrich, G. (author), Schaefer, H.E. (author), Dimmeler, S. (author), Kleemann, R. (author), Bernhagen, J. (author), Ihling, C. (author), Gaubius Instituut TNO (author)

Background - Atherosclerosis is a chronic inflammatory response of the arterial wall to injury. Macrophage migration inhibitory factor (MIF), a cytokine with potent inflammatory functions, was thus considered to be important in atherosclerotic lesion evolution. Methods and Results - We studied the presence and distribution of MIF...

article 2002

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Cytokine and IL-12 receptor mRNA discriminate between different clinical subtypes in multiple sclerosis

Boxel van-Dezaire, A.H.H. (author), Smits, M. (author), Trigt van-Hoff, S.C.J. (author), Killestein, J. (author), Houwelingen, J.C van (author), Polman, C.H (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)

Little is known about the involvement of cytokines in the pathogenesis of primary progressive (PP) multiple sclerosis (MS). We evaluated in this cross-sectional study whether IL-18, IL-12p35, IL-12p40, TNF-α, IFN-γ, IL-10, IL-4, TGF-β, IL-12Rβ1, and IL-12Rβ2 mRNA expression in unstimulated white blood cells showed significant differences between...

article 2001