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Krause, F. (author), Bosch, T. (author), Wilschut, E. (author), van Rhijn, G. (author)Technology aimed at providing cognitive support to operators in the manufacturing industry, is developing rapidly. Through technologies such as near-eye displays and augmented and mixed reality, the operator receives digital information and instructions to help the operator learn, and work efficiently and accurately. Companies, especially SMEs,...bookPart 2023
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Hasan, M.M. (author), Avramis, N. (author), Ranta, M. (author), El Baghdadi, M. (author), Hegazy, O. (author)This study presents the optimization and tuning of a simulation framework to improve its simulation accuracy while evaluating the energy utilization of electric buses under various mission scenarios. The simulation framework was developed using the low fidelity (Lo-Fi) model of the forward-facing electric bus (e-bus) powertrain to achieve the...article 2023
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Koene, F.G.H.F. (author), Eslami-Mossallam, B.B. (author)Future energy infrastructures are expected to be smart, with the application of energy storage and demand-side management strategies. To size the energy storage and assess the flexibility of the heat demand in a district, insight into its heat demand profile is a prerequisite. A tool was developed to generate the hourly space heating demand of a...article 2023
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Stolwijk, C.C.M. (author), M. Punter, L. (author), Hoekstra, M. (author)For this paper TNO and CIONET cooperated to conduct 20 interviews with CIOs from 7 European countries. CIONET is the community of CIOs, Digital Leaders and IT executives in Europe, UK, USA, Australia and LATAM.report 2023
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Schultes, E. (author), Roos, M. (author), Bonino da Silva Santos, L.O. (author), Guizzardi, G. (author), Bouwman, J. (author), Hankemeier, T. (author), Baak, A. (author), Mons, B. (author)Although all the technical components supporting fully orchestrated Digital Twins (DT) currently exist, what remains missing is a conceptual clarification and analysis of a more generalized concept of a DT that is made FAIR, that is, universally machine actionable. This methodological overview is a first step toward this clarification. We...article 2022
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van den Brink, W.J. (author), van den Broek, T.J. (author), Palmisano, S. (author), Wopereis, S. (author), de Hoogh, I.M. (author)Digital health technologies may support the management and prevention of disease through personalized lifestyle interventions. Wearables and smartphones are increasingly used to continuously monitor health and disease in everyday life, targeting health maintenance. Here, we aim to demonstrate the potential of wearables and smartphones to (1)...article 2022
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van Leeuwen, C.J. (author), Bouter, C.A. (author), Hindriks, H.N. (author), Wilterdink, R.W.J. (author)The Industry 4.0 Asset Administration Shell provides a standardized mechanism for collaboration between digital systems in the factory. Digital data within factories is typically stored in databases, we explore the requirements of providing an AAS as an interface to the data contained within the aforementioned databases. Based on these...conference paper 2022
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Digital Product-Service Systems: The Role of Data in the Transition to Servitization Business ModelsLangley, D.J. (author)The Circular Economy, as a guiding model for business processes, is attracting interest due to its potential for aligning business and societal goals as it offers companies the opportunity to simultaneously focus on economic value creation and on the mitigation of environmental damage. It is becoming increasingly clear that digital technologies...article 2022
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Korevaar, C.W. (author), Boschma, J.J. (author), den Breeje, R. (author), Ebert, J. (author)Optical feeder links (OFLs) benefit from the vast amount of bandwidth available in the THz-regime of the electro-magnetic spectrum, and could enable future terabit-per-second satellite systems. This study assesses the end-to-end performance of analog coherent OFLs for digital video broadcasting (DVB) applications, employing phase modulation (PM)...conference paper 2022
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Semertzis, I. (author), Rajkumar, V.S. (author), Ştefanov, A. (author), Fransen, F. (author), Palensky, P. (author)Over the past decade, the number of cyber attack incidents targeting critical infrastructures such as the electrical power system has increased. To assess the risk of cyber attacks on the cyber-physical system, a holistic approach is needed that considers both system layers. However, the existing risk assessment methods are either qualitative in...conference paper 2022
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Bigaj - Van Vliet, A.J. (author), Allaix, D.L. (author), Kohler, D. (author), Scibilia, E. (author)This contribution is outlining the vision and approach developed in the IM-SAFE project towards the standardisation of monitoring, data-informed safety assessment and predictive maintenance policies of bridges and tunnels considering the integration of digital innovations and reports on the initial activity in the IM-SAFE project [1] that is...conference paper 2022
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van Veenstra, A.F. (author), Timan, T. (author)Impact assessments have long been used for policy evaluation as well as for assessing (emerging) technologies. Within the field of Digital Governance, impact assessments are often used to analyze policy implications or to assess the impact of technologies such as big data and artificial intelligence on public services. Furthermore, within this...bookPart 2022
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Spataru, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Le Masne, Q. (author), Quarteroni, S. (author), Koledova, E.B. (author)Background. Our aim was to develop a machine learning model, using real-world data captured from a connected auto-injector device and from early indicators from the first 3 months of treatment, to predict sub-optimal adherence to recombinant human growth hormone (r-hGH) in patients with growth disorders. Methods. Adherence to r-hGH treatment was...article 2022
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Savage, M.O. (author), Fernandez-Luque, L. (author), Graham, S. (author), van Dommelen, P. (author), Araujo, M. (author), de Arriba, A. (author), Koledova, E. (author)Pediatric growth hormone (GH) deficiency is a licensed indication for replacement therapy with recombinant human growth hormone (r-hGH). Treatment, consisting of daily subcutaneous injections, extends from the time of diagnosis until cessation of linear growth at completion of puberty. Suboptimal adherence to r-hGH therapy is common and has been...article 2022
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Fratric, P. (author), Sileno, G. (author), Van Engers, T. (author), Klous, S. (author)With the uptake of digital services in public and private sectors, the formalization of laws is attracting increasing attention. Yet, non-compliant fraudulent behaviours (money laundering, tax evasion, etc.) - practical realizations of violations of law - remain very difficult to formalize, as one does not know the exact formal rules that define...conference paper 2022
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Ryan-Collins, J. (author), Dhondt, S. (author), Ghirlanda, P. (author), Kirov, V. (author), Mazzucato, M. (author), Strauss, I. (author)Major digital platforms play an increasingly important role in determining the trajectory of modern economies, innovation and employment dynamics. We examine how leading digital platforms based in the U.S. and Europe create and extract value in entrepreneurial ecosystems in the European Union. Whilst there are important differences between the...report 2022
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Paardekooper, J.P. (author), Comi, M. (author), Grappiolo, C. (author), Snijders, R. (author), van Vught, W. (author), Beekelaar, R. (author)An increasing number of tasks is being taken over from the human driver as automated driving technology is developed. Accidents have been reported in situations where the automated driving technology was not able to function according to specifications. As data-driven Artificial Intelligence (AI) systems are becoming more ubiquitous in automated...conference paper 2021
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Westbeek, S. (author), Remmers, J.J.C. (author), van Dommelen, J.A.W. (author), Maalderink, H.H. (author), Geers, M.G.D. (author)In photopolymerization-based additive manufacturing a complex interplay exists between the vat photopolymerization process characteristics and the (photo-active) resin’s material properties, which governs the trajectory from the input target geometry to the resulting true geometry of a printed component. Particularly for fine featured geometries...article 2021
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van der Haar, S. (author), Hoevenaars, F.P.M. (author), van den Brink, W.J. (author), van den Broek, T. (author), Timmer, M. (author), Boorsma, A. (author), Doets, E.L. (author)Background: Dietary quality plays an essential role in the prevention and management of metabolic syndrome (MetS). Objective: The aim of this pilot study is to organize personalized dietary advice in a real-life setting and to explore the effects on dietary intake, metabolic health, and perceived health. Methods: We followed a one-group pretest...article 2021
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Spataru, A. (author), Quarteroni, S. (author), Arnaud, L. (author), van Dommelen, P. (author), Koledova, E.B. (author), Le Masne, Q. (author)The early adoption of digital health solutions in the treatment of growth disorders has enabled the collection and analysis of more than 10 years of real-world data using the easypod™ connect platform. Using this rich dataset, we were able to study the impact of engagement on three key treatment-related outcomes: adherence, persistence of use,...article 2021