Searched for: subject:"Digestion"
(1 - 20 of 102)

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Smits, M. (author), Nooijen, I. (author), Redegeld, F. (author), de Jong, A. (author), Le, T.M. (author), Knulst, A. (author), Houben, G.F. (author), Verhoeckc, K.C.M. (author)
Scope: No accepted and validated methods are currently available which can accurately predict protein allergenicity. In this study, the role of digestion and transport on protein allergenicity is investigated. Methods and results: Peanut allergens (Ara h 1, 2, 3, and 6) and a milk allergen (β-lactoglobulin) are transported across pig intestinal...
article 2021
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Verhoeckx, K. (author), Bogh, K.L. (author), Dupont, D. (author), Egger, L. (author), Gadermaier, G. (author), Larre, C. (author), Mackie, A. (author), Menard, O. (author), Adel-Patient, K. (author), Picariello, G. (author), Portmann, R. (author), Smit, J. (author), Turner, P. (author), Untersmayr, E. (author), Epstein, M.M. (author)
The current allergenicity assessment of novel proteins is based on the EFSA GMO guidance. Recently, EFSA launched a new guidance document on allergenicity assessment of GM plants (2017). This document describes, amongst other topics, the new scientific and regulatory developments on in vitro protein digestibility tests. The EFSA GMO Panel stated...
article 2019
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Bellmann, S. (author), Krishnan, S. (author), de Graaf, A. (author), de Ligt, R.A. (author), Pasman, W.J. (author), Minekus, M. (author), Havenaar, R. (author)
The expected increase of global obesity prevalence makes it necessary to have information about the effects of meal intakes on the feeling of appetite. Because human clinical studies are time and cost intensive, there is a need for a reliable alternative. The aim of this study was to develop and evaluate an in vitro-in silico technology to...
article 2019
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Fallaize, R. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), San-Cristobal, R. (author), Navas-Carretero, S. (author), Marsaux, C.F.M. (author), O’Donovan, C.B. (author), Kolossa, S. (author), Moschonis, G. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Bouwman, J. (author), Manios, Y. (author), Jarosz, M. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gundersen, T.E. (author), Drevon, C.A. (author), Gibney, M.J. (author), Mathers, J.C. (author), Lovegrove, J.A. (author)
Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore,...
article 2018
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Botschuijver, S. (author), Welting, O. (author), Levin, E. (author), Maria-Ferreira, D. (author), Koch, E. (author), Montijn, R.C. (author), Seppen, J. (author), Hakvoort, T.B.M. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), van den Wijngaard, R.M. (author)
Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder associated with altered gastrointestinal microflora and increased nociception to colonic distension. This visceral hypersensitivity can be reversed in our rat maternal separation model by fungicides. Menthacarin® is a proprietary combination of essential oils from...
article 2018
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Pantophlet, A.J. (author), Wopereis, S. (author), Eelderink, C. (author), Vonk, R.J. (author), Stroeve, J.H. (author), Bijlsma, S. (author), van Stee, L. (author), Bobeldijk, I. (author), Priebe, M.G. (author)
Background: The consumption of products rich in cereal fiber and with a low glycemic index is implicated in a lower risk of metabolic diseases. Previously, we showed that the consumption of fiber-rich pasta compared with bread resulted in a lower rate of appearance of exogenous glucose and a lower glucose clearance rate quantified with a dual...
article 2017
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Minekus, M. (author)
The TNO Gastro–Intestinal Model (TIM) is a multi–compartmental model, designed to realistically simulate conditions in the lumen of the gastro–intestinal tract. TIM is successfully used to study the gastro–intestinal behavior of a wide variety of feed, food and pharmaceutical products. Experiments in TIM are based on a computer simulation of the...
bookPart 2015
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Offermans, N.S.M. (author), Vermeulen, R. (author), Burdorf, A. (author), Goldbohm, R.A. (author), Keszei, A.P. (author), Peters, S. (author), Kauppinen, T. (author), Kromhout, H. (author), van den Brandt, P.A. (author)
Objectives The evidence for an association between occupational asbestos exposure and pharyngeal cancer (PhC) is limited, while for oral cavity cancer (OCC) the literature is even sparser. We studied OCC and PhC risk both separately and combined (OCPC) in relation to occupational asbestos exposure, specifically addressing the influence of...
article 2014
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Minekus, M. (author), Alminger, M. (author), Alvito, P. (author), Ballance, S. (author), Bohn, T. (author), Bourlieu, C. (author), Carrière, F. (author), Boutrou, R. (author), Corredig, M. (author), Dupont, D. (author), Dufour, C. (author), Egger, L. (author), Golding, M. (author), Karakaya, S. (author), Kirkhus, B. (author), Le Feunteun, S. (author), Lesmes, U. (author), MacIerzanka, A. (author), MacKie, A. (author), Marze, S. (author), McClements, D.J. (author), Ménard, O. (author), Recio, I. (author), Santos, C.N. (author), Singh, R.P. (author), Vegarud, G.E. (author), Wickham, M.S.J. (author), Weitschies, W. (author), Brodkorb, A. (author)
Simulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of...
article 2014
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van Loo-Bouwman, C.A. (author), Naber, T.H.J. (author), Minekus, M. (author), van Breemen, R.B. (author), Hulshof, P.J.M. (author), Schaafsma, G. (author)
Since the food matrix determines β-carotene availability for intestinal absorption, food matrix effects on the bioaccessibility of β-carotene from two diets were investigated in vitro and compared with in vivo data. The "mixed diet" consisted of β-carotene-rich vegetables, and the "oil diet" contained β-carotene-low vegetables with supplemental...
article 2014
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Helbig, A. (author), Silletti, E. (author), van Aken, G.A. (author), Oosterveld, A. (author), Minekus, M. (author), Hamer, R.J. (author), Gruppen, H. (author)
This study investigated the effect of gastric passage of protein stabilized emulsions, i.e., whey protein isolate (WPI) and lysozyme, under dynamic in vitro conditions on both the gastric and intestinal lipolysis. Emulsions were prepared at neutral pH to enable an opposite surface charge. Experiments were performed in a multi-compartmental...
article 2013
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Havenaar, R. (author), de Jong, A. (author), Koenen, M.E. (author), van Bilsen, J. (author), Janssen, A.M. (author), Labij, E. (author), Westerbeek, H.J.M. (author)
Aim of this study was to investigate the digestion of transglutaminase cross-linked caseinate (XLC) versus native caseinate (NC) in solution and in cheese spread under digestive conditions for adults and children mimicked in a gastrointestinal model. Samples were collected for gel electrophoresis and nitrogen analysis. The results showed no...
article 2013
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Ahmadi-Abhari, S. (author), Woortman, A.J.J. (author), Oudhuis, A.A.C.M. (author), Hamer, R.J. (author), Loos, K. (author)
This study was aimed to assess the role of lysophosphatidylcholine (LPC) in the development of slowly digestible starch (SDS). The influence of LPC, on the enzymatic degradation of diluted 9% wheat starch suspensions (w/w) was investigated, using an in vitro digestion method. Wheat starch suspensions containing 0.5-5% LPC (based on starch) were...
article 2013
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Peters, R. (author), Kramer, E. (author), Oomen, A.G. (author), Herrera Rivera, Z.E. (author), Oegema, G. (author), Tromp, P.C. (author), Fokkink, R. (author), Rietveld, A. (author), Marvin, H.J.P. (author), Weigel, S. (author), Peijnenburg, A.A.C.M. (author), Bouwmeester, H. (author)
The presence, dissolution, agglomeration state, and release of materials in the nano-size range from food containing engineered nanoparticles during human digestion is a key question for the safety assessment of these materials. We used an in vitro model to mimic the human digestion. Food products subjected to in vitro digestion included (i) hot...
article 2012
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Abrahamse, E. (author), Minekus, M. (author), van Aken, G.A. (author), van de Heijning, B. (author), Knol, J. (author), Bartke, N. (author), Oozeer, R. (author), van der Beek, E.M. (author), Ludwig, T. (author)
At least during the first 6 months after birth, the nutrition of infants should ideally consist of human milk which provides 40-60 % of energy from lipids. Beyond energy, human milk also delivers lipids with a specific functionality, such as essential fatty acids (FA), phospholipids, and cholesterol. Healthy development, especially of the...
article 2012
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Zhu, Y. (author)
article 2011
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Garthoff, J.A. (author), Heemskerk, S. (author), Hempenius, R.A. (author), Lina, B.A.R. (author), Krul, C.A.M. (author), Koeman, J.H. (author), Speijers, G.J.A. (author), TNO Kwaliteit van Leven (author)
Pectin-derived acidic oligosaccharides (pAOS) are non-digestible carbohydrates to be used in infant formulae and medical nutrition. To support its safety, the genotoxic potential of pAOS was evaluated. pAOS was not mutagenic in the Ames test. Positive results were obtained in the chromosome aberration test only at highly cytotoxic concentrations...
article 2010
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Hemery, Y.M. (author), Anson, N.M. (author), Havenaar, R. (author), Haenen, G.R.M.M. (author), Noort, M.W.J. (author), Rouau, X. (author), TNO Kwaliteit van Leven (author)
This study evaluated the potential of using ultra-fine grinding and electrostatic separation of wheat bran as methods to improve the bioaccessibility of para-coumaric acid (pCA), sinapic acid (SA) and ferulic acid (FA) from bran-rich breads. Bran fractions were produced and used to bake white bread, whole-grain bread, and seven different bran...
article 2010
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TNO Kwaliteit van Leven (author), Koppelman, S.J. (author), Hefle, S.L. (author), Taylor, S.L. (author), de Jong, G.A.H. (author)
Scope: There are differences in stability to pepsin between the major allergens in peanut; however, data are from different reports using different digestion models. This study provides a comprehensive comparison of the digestibility of the major peanut allergens.Methods and results: Peanut allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 were...
article 2010
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Maathuis, A. (author), Hoffman, A. (author), Evans, A. (author), Sanders, L. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE: To investigate the effect of 5 newly developed maize-based fibers on the activity and composition of the microbiota in the colon. The fibers tested were glucose-based and had variable structures, including 2 resistant starch preparations, soluble corn fiber, pullulan, and soluble fiber dextrin. METHODS: The fibers were predigested,...
article 2009
Searched for: subject:"Digestion"
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