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Identification of biomarkers for intake of protein from meat, dairy products and grains: A controlled dietary intervention study

Altorf-van der Kuil, W. (author), Brink, E.J. (author), Boetje, M. (author), Siebelink, E. (author), Bijlsma, S. (author), Engberink, M.F. (author), Veer, P.V.'. (author), Tomé, D. (author), Bakker, S.J.L. (author), van Baak, M.A. (author), Geleijnse, J.M. (author)

In the present controlled, randomised, multiple cross-over dietary intervention study, we aimed to identify potential biomarkers for dietary protein from dairy products, meat and grain, which could be useful to estimate intake of these protein types in epidemiological studies. After 9 d run-in, thirty men and seventeen women (22 (sd 4) years)...

article 2013

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Effects of organically and conventionally produced feed on biomarkers of health in a chicken model

TNO Kwaliteit van Leven (author), Huber, M. (author), van de Vijver, L.P.L. (author), Parmentier, H. (author), Savelkoul, H. (author), Coulier, L. (author), Wopereis, S. (author), Verheij, E. (author), van der Greef, J. (author), Nierop, D. (author), Hoogenboom, R.A.P. (author)

Consumers expect organic products to be healthier. However, limited research has been performed to study the effect of organic food on health. The present study aimed to identify biomarkers of health to enable future studies in human subjects. A feeding experiment was performed in two generations of three groups of chickens differing in immune...

article 2010

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Associations of gestational exposure to famine with energy balance and macronutrient density of the diet at age 58 years differ according to the reference population used

Stein, A.D. (author), Rundle, A. (author), Wada, N. (author), Goldbohm, R.A. (author), Lumey, L.H. (author), TNO Kwaliteit van Leven (author)

Individuals exposed to the Dutch Famine of 1944-45 during gestation have increased adiposity, which might be due to changes in energy intake, physical activity, or metabolic efficiency.We studied 357 persons born between January 1945 and March 1946 whose mothers experienced famine during or immediately preceding pregnancy, 298 persons born in...

article 2009

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Macronutrient distribution over a period of 23 years in relation to energy intake and body fatness

TNO Kwaliteit van Leven (author), Koppes, L.L.J. (author), Boon, N. (author), Nooyens, A.C.J. (author), van Mechelen, W. (author), Saris, W.H.M. (author)

The distribution of the four macronutrients is associated with energy intake and body fatness according to short-term interventions. The present study involves macronutrient distribution in relation to energy intake and body fatness over a period of 23 years in individuals who have ad libitum access to food. Eight follow-up measurements have...

article 2009

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Probabilistic risk assessment model for allergens in food: Sensitivity analysis of the minimum eliciting dose and food consumption

Kruizinga, A.G. (author), Briggs, D. (author), Crevel, R.W.R. (author), Knulst, A.C. (author), Bosch, L.M.C.v.d. (author), Houben, G.F. (author), TNO Kwaliteit van Leven (author), KvL (author)

Previously, TNO developed a probabilistic model to predict the likelihood of an allergic reaction, resulting in a quantitative assessment of the risk associated with unintended exposure to food allergens. The likelihood is estimated by including in the model the proportion of the population who is allergic, the proportion consuming the food and...

article 2008

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High-protein and high-carbohydrate breakfasts differentially change the transcriptome of human blood cells

van Erk, M.J. (author), Blom, W.A.M. (author), van Ommen, B. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)

Background: Application of transcriptomics technology in human nutrition intervention studies would allow for genome-wide screening of the effects of specific diets or nutrients and result in biomarker profiles. Objective: The aim was to evaluate the potential of gene expression profiling in blood cells collected in a human intervention study...

article 2006

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Effect of a high-protein breakfast on the postprandial ghrelin response

Blom, W.A.M. (author), Lluch, A. (author), Stafleu, A. (author), Vinoy, S. (author), Holst, J.J. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)

Background: The most satiating macronutrient appears to be dietary protein. Few studies have investigated the effects of dietary protein on ghrelin secretion in humans. Objective: This study was designed to investigate whether a high-protein (HP) breakfast is more satiating than a high-carbohydrate breakfast (HC) through suppression of...

article 2006

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The intake of total protein, natural protein and protein substitute and growth of height and head circumference in Dutch infants with phenylketonuria

Hoeksma, M. (author), van Rijn, M. (author), Verkerk, P.H. (author), Bosch, A.M. (author), Mulder, M.F. (author), de Klerk, J.B.C. (author), de Koning, T.J. (author), Rubio-Gozalbo, E. (author), de Vries, M. (author), Sauer, P.J.J. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)

In a previous study, Dutch children with phenylketonuria (PKU) were found to be slightly shorter than their healthy counterparts. In the literature, it has been hypothesized that a higher protein intake is necessary to optimize growth in PKU patients. The study aimed to investigate whether protein intake (total, natural and protein substitute)...

article 2005

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A high-protein diet increases postprandial but not fasting plasma total homocysteine concentrations: A dietary controlled, crossover trial in healthy volunteers

Verhoef, P. (author), van Vliet, T. (author), Olthof, M.R. (author), Katan, M.B. (author), TNO Kwaliteit van Leven (author)

Background: A high plasma concentration of total homocysteine (tHcy) is associated with increased risk of cardiovascular disease. A high protein intake and hence a high intake of methionine-the sole dietary precursor of homocysteine-may raise plasma tHcy concentrations. Objectives: We studied whether high intake of protein increases plasma...

article 2005

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Fruits, vegetables, and hMLH1 protein-deficient and -proficient colon cancer: The Netherlands cohort study

Wark, P.A. (author), Weijenberg, M.P. (author), van 't Veer, P. (author), van Wijhe, G. (author), Luchtenborg, M. (author), van Muijen, G.N.P. (author), de Goeij, A.F.P.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)

Background: Clinical and pathologic differences exist between colon carcinomas deficient and proficient in the mismatch repair protein hMLH1. Animal and in vitro studies suggest that fruits, vegetables, folate, and antioxidants are associated with colonic expression of mismatch repair genes. Methods: Associations between consumption of fruits...

article 2005

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Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: A randomized crossover trial in humans

Verhoef, P. (author), Steenge, G.R. (author), Boelsma, E. (author), van Vliet, T. (author), Olthof, M.R. (author), Katan, M.B. (author), TNO Voeding (author)

Background: A high plasma total homocysteine (tHcy) concentration is a risk factor for cardiovascular disease. The increase in tHcy induced by methionine, the sole dietary precursor of homocysteine, might be modulated by other amino acids present in dietary proteins. Objectives: Our objectives were to compare the postprandial effect of free and...

article 2004

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Effect of dietary protein source on feed intake and small intestinal morphology in newly weaned piglets

Vente-Spreeuwenberg, M.A.M. (author), Verdonk, J.M.A.J. (author), Bakker, G.C.M. (author), Beynen, A.C. (author), Verstegen, M.W.A. (author), TNO Animal Nutrition (author)

An experiment was designed to study the effect of dietary protein source on feed intake and on small intestinal morphology in newly weaned piglets. In total, 108 piglets were used, without access to creep feed during the suckling period. Piglets were weaned at 27 days of age. They were fed ad libitum one of two iso-nitrogenous experimental diets...

article 2004

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Dietary intake and nutritional status of children and adolescents in Europe

TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Lambert, J. (author), Agostoni, C. (author), Elmadfa, I. (author), Hulshof, K. (author), Krause, E. (author), Livingstone, B. (author), Socha, P. (author), Pannemans, D. (author), Samartín, S. (author)

The objective of this project was to collect and evaluate data on nutrient intake and status across Europe and to ascertain whether any trends could be identified. Surveys of dietary intake and status were collected from across Europe by literature search and personal contact with country experts. Surveys that satisfied a defined set of criteria...

article 2004

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Assessment of protein allergenicity on the basis of immune reactivity: Animal models

Kimber, I. (author), Dearman, R.J. (author), Penninks, A.H. (author), Knipples, L.M.J. (author), Buchanan, R.B. (author), Hammerberg, B. (author), Jackson, H.A. (author), Helm, R.M. (author)

Because of the public concern surrounding the issue of the safety of genetically modified organisms, it is critical to have appropriate methodologies to aid investigators in identifying potential hazards associated with consumption of foods produced with these materials. A regent panel of experts convened by the Food and Agriculture Organization...

article 2003

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Effect of dietary protein source and lysine: DE ratio on growth performance, meat quality and body composition of growing-finishing pigs

Szabó, C. (author), Jansman, A.J.M. (author), Babinszky, L. (author), Kanis, E. (author), Verstegen, M.W.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The effects of four protein sources (soybean meal, sunflower meal, pea, and fish meal as the main protein source) and three apparent ileally digestible Lys:DE ratios (0.50, 0.43, 0.36 and 0.42, 0.36, 0.30 g Lys/MJ DE for 30 to 60 kg BW and 60 to 105 kg BW, respectively) in pig diets on growing-finishing performance, and carcass and meat quality...

article 2001

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Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning

Centraal Instituut voor Voedingsonderzoek TNO (author), Spreeuwenberg, M.A.M. (author), Verdonk, J.M.A.J. (author), Gaskins, H.R. (author), Verstegen, M.W.A. (author)

Compromising alterations in gastrointestinal architecture are common during the weaning transition of pigs. The relation between villous atrophy and epithelial barrier function at weaning is not well understood. This study evaluated in vitro transepithelial transport by Ussing metabolic chambers, local alterations in T-cell subsets and villous...

article 2001

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Ingestion of protein hydrolysate and amino acid-carbohydrate mixtures increases postexercise plasma insulin responses in men

van Loon, L.J.C. (author), Kruijshoop, M. (author), Verhagen, H. (author), Saris, W.H.M. (author), Wagenmakers, A.J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

To optimize the postexercise insulin response and to increase plasma amino acid availability, we studied postexercise insulin levels after the ingestion of carbohydrate and wheat protein hydrolysate with and without free leucine and phenylalanine. After an overnight fast, eight male cyclists visited our laboratory on five occasions, during which...

article 2000

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Effects of food on cortisol and mood in vulnerable subjects under controllable and uncontrollable stress

Markus, R. (author), Panhuysen, G. (author), Tuiten, A. (author), Koppeschaar, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The aim of this study was to investigate whether in stress-prone subjects, carbohydrate-rich, protein-poor food (CR/PP) diminished depressive mood and a cortisol response under controllable as well as uncontrollable laboratory stress. Twenty-two subjects with high stress proneness (HS) and 23 subjects with low stress proneness (LS) participated...

article 2000

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Animal products and K-ras codon 12 and 13 mutations in colon carcinomas

Kampman, E. (author), Voskuil, D.W. (author), van Kraats, A.A. (author), Balder, H.F. (author), van Muijen, G.N.P. (author), Goldbohm, R.A. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

K-ras gene mutations (codons 12 and 13) were determined by PCR-based mutant allele-specific amplification (MASA) in tumour tissue of 185 colon cancer patients: 36% harboured mutations, of which 82% were located in codon 12. High intakes of animal protein, calcium and poultry were differently associated with codon 12 and 13 mutations: odds ratios...

article 2000

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Comparison of antibody responses to hen's egg and cow's milk proteins in orally sensitized rats and food-allergic patients

Knippels, L.M.J. (author), van der Kleij, H.P.M. (author), Koppelman, S.J. (author), Houben, G.F. (author), Penninks, A.H. (author), Felius, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Background: No adequate enteral sensitization models are available to study food allergy and the allergenicity of food proteins. To further validate an enteral brown Norway (BN) rat sensitization model under development, we studied specific protein recognition to determine whether a comparable pattern of proteins is recognized by the rat immune...

article 2000