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Kühnast, S. (author), van der Tuin, S.J.L. (author), van der Hoorn, J.W.A. (author), van Klinken, J.B. (author), Simic, B. (author), Pieterman, E. (author), Havekes, L.M. (author), Landmesser, U. (author), Lüscher, T.F. (author), van Dijk, K.W. (author), Rensen, P.C.N. (author), Jukema, J.W. (author), Princen, H.M.G. (author)Background The residual risk that remains after statin treatment supports the addition of other LDL-C-lowering agents and has stimulated the search for secondary treatment targets. Epidemiological studies propose HDL-C as a possible candidate. Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from atheroprotective HDL to...article 2015
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Kooijman, S. (author), Meurs, I. (author), van der Stoep, M. (author), Habets, K.L. (author), Lammers, B. (author), Berbée, J.F.P. (author), Havekes, L.M. (author), van Eck, M. (author), Romijn, J.A. (author), Korporaal, S.J.A. (author), Rensen, P.C.N. (author)Summary: Background: The autonomic nervous system attenuates inflammation through activation of the α7 nicotinic acetylcholine receptor (α7nAChR), a pathway termed the cholinergic anti-inflammatory reflex. Interestingly, α7nAChR is expressed on immune cells and platelets, both of which play a crucial role in the development of atherosclerosis....article 2015
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Aguirre, M. (author), Venema, K. (author)Recently, a great deal of interest has been expressed regarding strategies to tackle worldwide obesity because of its accelerated wide spread accompanied with numerous negative effects on health and high costs. Obesity has been traditionally associated with an imbalance in energy consumed when compared to energy expenditure. However, growing...article 2015
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Minihane, A.M. (author), Vinoy, S. (author), Russell, W.R. (author), Baka, A. (author), Roche, H.M. (author), Tuohy, K.M. (author), Teeling, J.L. (author), Blaak, E.E. (author), Fenech, M. (author), Vauzour, D. (author), McArdle, H.J. (author), Kremer, B.H.A. (author), Sterkman, L. (author), Vafeiadou, K. (author), Benedetti, M.M. (author), Williams, C.M. (author), Calder, P.C. (author)The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's...article 2015
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Derous, D. (author), Kelder, T. (author), van Schothorst, E.M. (author), van Erk, M. (author), Voigt, A. (author), Klaus, S. (author), Keijer, J. (author), Radonjic, M. (author)Health is influenced by interplay of molecular, physiological and environmental factors. To effectively maintain health and prevent disease, health-relevant relations need to be understood at multiple levels of biological complexity. Network-based methods provide a powerful platform for integration and mining of data and knowledge characterizing...article 2015
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Souverein, O.W. (author), de Vries, J.H.M. (author), Freese, R. (author), Watzl, B. (author), Bub, A. (author), III Miller, E.R., (author), Castenmiller, J.J.M. (author), Pasman, W.J. (author), van het Hof, K. (author), Chopra, M. (author), Karlsen, A. (author), Dragsted, L.O. (author), Winkels, R. (author), Itsiopoulos, C. (author), Brazionis, L. (author), O'Dea, K. (author), van Loo-Bouwman, C.A. (author), Naber, T.H.J. (author), van der Voet, H. (author), Boshuizen, H.C. (author)Fruit and vegetable consumption produces changes in several biomarkers in blood. The present study aimed to examine the dose-response curve between fruit and vegetable consumption and carotenoid (alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein and zeaxanthin), folate and vitamin C concentrations. Furthermore, a prediction...article 2015
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van der Tuin, S.J. (author), Kühnast, S. (author), Berbée, J. (author), Verschuren, L. (author), Pieterman, E.J. (author), Havekes, L.M. (author), van der Hoorn, J.W. (author), Rensen, P.C. (author), Jukema, J.W. (author), Princen, H.M. (author), Willems van Dijk, K. (author), Wang, Y. (author)Recently, we showed in APOE*3-Leiden.CETP mice that anacetrapib attenuated atherosclerosis development by reducing (V)LDL-C rather than by raising HDL-C. Here, we investigated the mechanism by which anacetrapib reduces (V)LDL-C and whether this effect was dependent on the inhibition of CETP. APOE*3-Leiden.CETP mice were fed a Western type diet...article 2015
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Wagner, A. (author), Cohen, N. (author), Kelder, T. (author), Amit, U. (author), Liebman, E. (author), Steinberg, D.M. (author), Radonjic, M. (author), Ruppin, E. (author)High-throughput omics have proven invaluable in studying human disease, and yet day-to-day clinical practice still relies on physiological, non-omic markers. The metabolic syndrome, for example, is diagnosed and monitored by blood and urine indices such as blood cholesterol levels. Nevertheless, the association between the molecular and the...article 2015
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Bessems, K.M.H.H. (author), van Assema, P. (author), de Vries, N.K. (author), Paulussen, T.W.G.M. (author)Strategies to promote implementation of school-based health promotion (HP) programmes should be designed to suit determinants of implementation and continuation. This study explored determinants of completeness of teachers' implementation of a healthy diet promotion programme and of their intention to continue the programme. Strategies for...article 2014
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Santoro, A. (author), Pini, E. (author), Scurti, M. (author), Palmas, G. (author), Berendsen, A. (author), Brzozowska, A. (author), Pietruszka, B. (author), Szczecinska, A. (author), Cano, N. (author), Meunier, N. (author), de Groot, C.P.G.M. (author), Feskens, E. (author), Fairweather-Tait, S. (author), Salvioli, S. (author), Capri, M. (author), Brigidi, P. (author), Franceschi, C. (author), Fabbri, C. (author), Bertarelli, C. (author), Izzi, M. (author), Mazzocchi, M. (author), Chardigny, J.M. (author), Morio, B. (author), Rossi, D. (author), Notarfonso, M. (author), O'Toole, P.W. (author), Cashman, K. (author), Carding, S.R. (author), Nicoletti, C. (author), Jacobs, D. (author), Xipsiti, M. (author), Fernandez, L. (author), Wills, J. (author), Irz, X. (author), Kuosmanen, N. (author), Gonos, E.S. (author), Voutetakis, K. (author), Salmon, M. (author), Toussaint, O. (author), Traill, B.W. (author), Nocella, G. (author), Caracciolo, B. (author), Xu, W. (author), Ikonen, M. (author), Tuure, T. (author), Brummer, R. (author), Kadi, F. (author), Breton, S. (author), Triomphe, M. (author), Magario, G. (author), Villani, F. (author), Pancrazio, A. (author), Teufner, B. (author), Stocker, J. (author), Echevarría, F.J. (author), Iglesias, J.R. (author), Smrž, F. (author), Krejcirova, L. (author), Koytsomitropoulou, E. (author), Georgakidis, K. (author), Yornuk, R. (author), Ucar, C. (author), van Ommen, B. (author), Bouwman, J. (author), Collino, S. (author), Jankovics, C. (author), Losó, A. (author), de Vos, W. (author), Fuentes, S. (author), Commelin, E. (author)The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale...article 2014
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Ezendam, N.P.M. (author), Burg, J. (author), Borsboom, G. (author), van Empelen, P. (author), Oenema, A. (author)OBJECTIVE: To explore whether the effects on dietary behaviours of a computer-tailored intervention aimed to prevent excessive weight gain among adolescents, FATaintPHAT, were moderated by sociodemographic, cognitive and home environmental factors. DESIGN: A two-group cluster randomized trial. Potential moderation of the outcome measures ...article 2014
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Boon, M.R. (author), Kooijman, S. (author), van Dam, A.D. (author), Pelgrom, L.R. (author), Berbée, J.F.P. (author), Visseren, C.A.R. (author), van Aggele, R.C. (author), van den Hoek, A.M. (author), Sips, H.C.M. (author), Lombès, M. (author), Havekes, L.M. (author), Tamsma, J.T. (author), Guigas, B. (author), Meijer, O.C. (author), Jukema, J.W. (author), Rensen, P.C.N. (author)The endocannabinoid system is an important player in energy metabolism by regulating appetite, lipolysis, and energy expenditure. Chronic blockade of the cannabinoid 1 receptor (CB1R) leads to long-term maintenance of weight loss and reduction of dyslipidemia in experimental and human obesity. The molecular mechanism by which CB1R blockade...article 2014
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de Oliveira, J.E. (author), van der Hoeven-Hangoor, E. (author), van de Linde, I.B. (author), Montijn, R.C. (author), van der Vossen, J.M.B.M. (author)The feasibility of establishing probiotic bacteria in the intestine of broiler chickens by in ovo inoculation was investigated, followed by verifying possible subsequent protection against Salmonella Enteriditis infection. In a first study, 7 commercially available probiotics were screened for compatibility with in ovo inoculation. Two of these...article 2014
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Ladirat, S.E. (author), Schoterman, M.H.C. (author), Rahaoui, H. (author), Mars, M. (author), Schuren, F.H.J. (author), Gruppen, H. (author), Nauta, A. (author), Schols, H.A. (author)In the present double-blind, randomised, parallel intervention study, the effects of the intake of galacto-oligosaccharides (GOS) on the gut microbiota of twelve healthy adult subjects (aged 18-45 years with a normal BMI (18-25 kg/m2)) receiving amoxicillin (AMX) treatment were determined. All the subjects were treated with AMX (375 mg; three...article 2014
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Lakerveld, J. (author), van der Ploeg, H.P. (author), Kroezel, W. (author), Ahrens, W. (author), Allais, O. (author), Frost Andersen, L. (author), Cardons, G. (author), Capranica, L. (author), Chastin, S. (author), Donnelly, A. (author), Ekelund, U. (author), Finglash, P. (author), Flechtner-Mors, M. (author), Hebestrei, A. (author), Hendriksen, I. (author), Kubiak, T. (author), Lanza, M. (author), Loyen, A. (author), MacDonncha, C. (author), Mazzocch, M. (author), Monsivais, P. (author), Murphy, M. (author), Nöthlings, U. (author), O’Gorman, D.J. (author), Renner, B. (author), Roos, G. (author), Schuit, A.J. (author), Schulze, M. (author), Steinacker, J. (author), Stronks, K. (author), Volkert, D. (author), van 't Veer, P. (author), Lien, N. (author), de Bourdeaudhuij, I. (author), Brug, J. (author)To address major societal challenges and enhance cooperation in research across Europe, the European Commission has initiated and facilitated ‘joint programming’. Joint programming is a process by which Member States engage in defining, developing and implementing a common strategic research agenda, based on a shared vision of how to address...article 2014
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Balvers, M.G.J. (author), Wortelboer, H.M. (author), Witkamp, R.F. (author), Verhoeckx, K.C.M. (author)The origin of N-acyl ethanolamides (NAEs) in plasma is not well understood, and it is possible that NAEs are present in plasma in esterified form. To test this hypothesis, a new and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of arachidonoyl ethanolamide, 2...article 2013
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Tielemans, S.M.A.J. (author), Geleijnse, J.M. (author), van Baak, M.A. (author), Engberink, M.F. (author), Brink, E.J. (author), de Jong, P.E. (author), Gansevoort, R.T. (author), Bakker, S.J.L. (author)OBJECTIVES: It is not yet clear whether dietary protein could help maintaining a healthy blood pressure (BP). We investigated the association between total protein intake, estimated from 24-h urinary urea excretion, and incident hypertension in Dutch men and women. METHODS: We analyzed data of 3997 men and women (aged 28-75 years) who...article 2013
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Dambacher, W.M. (author), de Kort, E.H.M. (author), Blom, W.M. (author), Houben, G.F. (author), de Vries, E. (author)Background: Children with cow's milk allergy (CMA) need a cow's milk protein (CMP) free diet to prevent allergic reactions. For this, reliable allergy-information on the label of food products is essential to avoid products containing the allergen. On the other hand, both overzealous labeling and misdiagnosis that result in unnecessary...article 2013
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Wopereis, S. (author), Radonjic, M. (author), Rubingh, C. (author), van Erk, M. (author), Smilde, A. (author), van Duyvenvoorde, W. (author), Cnubben, N. (author), Kooistra, T. (author), van Ommen, B. (author), Kleemann, R. (author)The prevalence of diabetes mellitus Type 2 could be significantly reduced by early identification of subjects at risk, allowing for better prevention and earlier treatment. Glucose intolerance (GI) is a hallmark of the prediabetic stage. This study aims at identifying 1) prognostic biomarkers predicting the risk of developing GI later in life...article 2012
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Louwe, M.C. (author), van der Hoorn, J.W.A. (author), van den Berg, S.A.A. (author), Wouter Jukema, J. (author), Romijn, J.A. (author), van Dijk, K.W. (author), Rensen, P.C.N. (author), Smit, J.W.A. (author), Steendijk, P. (author)Increased availability of fatty acids released from insulin-resistant adipose tissue may lead to excess fatty acid uptake in nonadipose organs, including the heart. Accumulation of toxic fatty acid intermediates may affect cardiac function. Our aim was to identify to which extent high-fat diet feeding leads to alterations in cardiac function and...article 2012