Cost-effectiveness of newborn screening for cystic fibrosis determined with real-life data

BACKGROUND: Previous cost-effectiveness studies using data from the literature showed that newborn screening for cystic fibrosis (NBSCF) is a good economic option with positive health effects and longer survival. METHODS: We used primary data to compare cost-effectiveness of four screening strategies for NBSCF, i.e. immunoreactive trypsinogen...

Hearing loss by week of gestation and birth weight in very preterm neonates

Objective To gain insight into health and related costs associated with very preterm births, one needs accurate information about the prevalence of the disabling conditions, including neonatal hearing loss (NHL). Study design We assessed the prevalence of NHL by week of gestation and categories of birth weight in very preterm neonates. Results...

Swimming pool attendance and respiratory symptoms and allergies among Dutch children

Objectives: To describe associations among swimming, respiratory health, allergen sensitisation and Clara cell protein 16 (CC16) levels in Dutch schoolchildren. Trichloramine levels in swimming pool air were determined to assess potential exposure levels. Methods: Respiratory health and pool attendance information was collected from 2359...

ADEM en het risico op het ontwikkelen van MS bij kinderen [ADEM and the risk of developing of MS with children]

Acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) in children are relatively rare and the exact incidence is still unknown. There is great variability in clinical presentation and disease course. It is yet unclear which clinical and biological parameters can predict a chronic disease course and progression to multiple...

Motion sickness provoked by torso rotation

Henoch-Schönlein purpura in children: An epidemiological study among Dutch paediatricians on incidence and diagnostic criteria

Background: The aim of the present study on the occurrence of Henoch-Schönlein Purpura (HSP) in Dutch children is to give some insight into the epidemiology of HSP in the Netherlands, to record the diagnostic criteria used by Dutch paediatricians and to evaluate the accuracy of the latter using the presence of IgA in the skin when biopsies are...

Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions

This paper presents a test strategy to detect interactive effects between several mycotoxins using a DNA synthesis inhibition assay in L929 cells. The joint action of the Fusarium mycotoxins T-2 toxin (T2), deoxynivalenol (DON), nivalenol (NIV), zearalenone (ZEA) and fumonisin (FB1) was studied in a tiered approach. In the first stage, the...

Opsporing familiaire hypercholesterolemie bij kinderen geindiceerd? Bij uitzondering wel [Search for familial hypercholesterolaemia in children indicated? Only exceptionally]

Searching for familial hypercholesterolaemia (FH) in children is useful only if efficacious treatment is to be administered shortly and if there are relatives with ischaemic heart disease at very early ages. In all other cases, the (psychological) drawbacks probably outweigh the doubtful benefit of early intervention. The search for the major...

Knowledge and strategies in diagnostic skill

A theoretical framework for diagnosis in technical environments is presented, consisting of three layers. At the first layer, the task structure, top-level goals of the diagnostic tasks are identified that have to be fulfilled during task execution. This task structure may also be viewed as a global strategy to carry out the diagnostic task. The...