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Reijneveld, S.A. (author), Brugman, E. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author)Objective. To assess the degree to which preventive child health professionals (CHPs) identify and manage psychosocial problems among pre-school children in the general population, and to determine its association with parent-reported behavioral and emotional problems, sociodemographic factors and (mental) health history of children. Design....article 2005
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TNO Kwaliteit van Leven (author), Lindon, J.C. (author), Nicholson, J.K. (author), Holmes, E. (author), Keun, H.C. (author), Craig, A. (author), Pearce, J.T.M. (author), Bruce, S.J. (author), Hardy, N. (author), Sansone, S.A. (author), Antti, H. (author), Jonsson, P. (author), Daykin, C. (author), Navarange, M. (author), Beger, R.D. (author), Verheij, E.R. (author), Amberg, A. (author), Baunsgaard, D. (author), Cantor, G.H. (author), Lehman-McKeeman, L. (author), Earll, M. (author), Wold, S. (author), Johansson, E. (author), Haselden, J.N. (author), Kramer, K. (author), Thomas, C. (author), Lindberg, J. (author), Schuppe-Koistinen, I. (author), Wilson, I.D. (author), Reily, M.D. (author), Robertson, D.G. (author), Senn, H. (author), Krotzky, A. (author), Kochhar, S. (author), Powell, J. (author), van der Ouderaa, F. (author), Plumb, R. (author), Schaefer, H. (author), Spraul, M. (author)The Standard Metabolic Reporting Structures (SMRS) working group outlines its vision for an open, community-driven specification for the standardization and reporting of metabolic studies.article 2005
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Noort, D. (author), Fidder, A. (author), de Kant, S. (author), Hulst, A.G. (author), Prins Maurits Laboratorium TNO (author)The need for retrospective detection procedures for exposure to low levels of chemical warfare agents has been urgently illustrated by the conflicts in the Gulf Area. Furthermore, in the case of a terrorist attack with CWA, rapid and reliable diagnosis of the exposure is essential. The present research aims at development of a mass spectrometric...conference paper 2004
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Mittag, D. (author), Akkerdaas, J. (author), Ballmer-Weber, B.K. (author), Vogel, L. (author), Wensing, M. (author), Becker, W.M. (author), Koppelman, S.J. (author), Knulst, A.C. (author), Helbling, A. (author), Hefle, S.L. (author), van Ree, R. (author), Vieths, S. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)We recently described patients with soybean allergy mainly mediated by cross-reactivity to birch pollen allergens. A majority of those patients were reported to have peanut allergy. We sought to study the occurrence of peanut allergy in patients allergic to birch pollen and characterized the Bet v 1-homologous peanut allergen Ara h 8....article 2004
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Zagers, N.P.A. (author), van Norren, D. (author)We measured the amplitude of the directional component of the bleached fundus reflectance, the so-called optical Stiles-Crawford effect, as a function of wavelength. The directional reflectance originates from within the outer segments of the photoreceptors. Thus only two anterior absorbers are of importance: Macular pigment and the crystalline...article 2004
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van Helden, H.P.M. (author), Trap, H.C. (author), Kuijpers, W.C. (author), Oostdijk, J.P. (author), Vanwersch, R.A.P. (author), Phillippens, I.H.C.H.M. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)Realistic scenarios for low-level exposure to nerve agents will often involve exposures over several hours to extremely low doses of agent. The purpose of this pilot study was to indicate for sarin: (i) the lowest observable effect level (LOEL), i.e., the C.t-value (t = 5 h) of exposure at which an internal dose (fluoride-regenerated sarin from...conference paper 2004
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TNO Arbeid (author), Hale, A.R. (author), Waterbeemd, H.A.V.D. (author), Potter, R. (author), Heming, B.H. (author), Swuste, P.H.J.J. (author), Guldenmund, F.W. (author)The paper describes the methods used for a study of the safety management system and culture of a cold rolling mill in a steel plant. It uses data from diverse sources which can be validated against each other and combined to produce a rich picture of the current risk control system and its shortcomings. The paper also describes the proposed...article 2004
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Lubbers, J. (author), Hekkenberg, R.T. (author), Bezemer, R.A. (author), TNO Preventie en Gezondheid (author)Activities in the standardisation of medical ultrasonic imaging and monitoring devices have been undertaken to ensure the safe application and to provide the user with tools to perform risk-to-benefit analysis. Internationally, agreement has not been reached to implement a system based on a physical quantity such as temperature rise. Therefore,...article 2003
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van Lieshout, J.J. (author), Toska, K. (author), van Lieshout, E.J. (author), Eriksen, M. (author), Walløe, L. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)The proper understanding of the cardiovascular mechanisms involved in complaints of short-lasting dizziness and the evaluation of unexplained recurrent syncope requires continuous monitoring of cardiac stroke volume (SV) in addition to blood pressure and heart rate. The primary aim of the present study was to evaluate a pulse wave analysis...article 2003
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van Velzen-Mol, H.W.M. (author), Blankespoor, M.N. (author), Wagenaar-Fischer, M.M. (author), van Leerdam, F.J.M. (author)The child health-care guideline 'Detection of visual disorders at the age of 0-19' draws attention to the importance of early detection of visual disorders and provides guidelines to child health-care workers for detecting disorders during routine check-ups. Children under the age of 3 are examined by the 'Early detection of visual disorders'...article 2003
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Verloove-Vanhorick, S.P. (author), Verkerk, P.H. (author), van Leerdam, F.J.M. (author), Reijneveld, S.A. (author), HiraSing, R.A. (author)As part of government policy, the 'Youth healthcare' prevention programme is offered free of charge to all children aged 0 to 19 years who are resident in the Netherlands. It consists of a programme of primary prevention (including vaccinations, information and advice) and secondary prevention (screening, surveillance, early diagnosis) and...article 2003
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Reijneveld, S.A. (author), Vogels, A.G.C. (author), Brugman, E. (author), van Ede, J. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author)Background: Psychosocial problems, such as behavioural, emotional, and educational problems, are highly prevalent among children and adolescents. Early treatment may reduce these problems, if accurately identified. Validated questionnaires may support identification. The aim of this study is to assess the psychometric qualities of such a...article 2003
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Renders, C.M. (author), Delemarre-van De Waal, H.A. (author), Dekker, J.M. (author), Hirasing, R.A. (author)The prevalence of overweight and obesity in children is increasing significantly. This increase is attended by an increase in diabetes type 2 in children and adolescents. The most important risk factor for the rise of insulin resistance amongst young people is overweight. The diagnostic criteria for diabetes mellitus in young people are: (a)...article 2003
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van der Pal-de Bruin, K.M. (author), Graafmans, W. (author), Biermans, M.C.J. (author), Richardus, J.H. (author), Zijlstra, A.G. (author), Reefhuis, J. (author), Mackenbach, J.P. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)Objectives This study concerns the possible effect of practice of prenatal screening of congenital anomalies followed by termination of pregnancy on the perinatal mortality between European countries. Methods Data of nine region-specific EUROCAT registries from five European countries were used to compare the pregnancy termination rate and...article 2002
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Hopman-Rock, M. (author), Tak, E.C.P.M. (author), Staats, P.G.M. (author)Objective: Development and validation of a short Observation List of possible early signs of Dementia (OLD) for use in general practice. Design: Stepwise development using reviews of publications and expert consensus. Field study for evaluation of reliability. Validation study (interviews, family forms) using existing valid and reliable measures...article 2001
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Noort, D. (author), Fidder, A. (author), Hulst, A.G. (author), de Jong, L.P.A. (author), Benschop, H.P. (author), Department of Chemical Toxicology, TNO Prins Maurits Laboratory, PO Box 45, 2280 AA Rijswijk, Netherlands Department of Analysis of Toxic and Explosive Substances, TNO Prins Maurits Laboratory, PO Box 45, 2280 AA Rijswijk, Netherlands (author)Experiments were carried out to develop a standard operating procedure for analysis of sulfur mustard adducts to the N-terminal valine in haemoglobin and to explore adduct formation with albumin and keratin. In the first approach, gas chromatography-negative chemical ionization/mass spectrometry (GC-NCI/MS) of the thiohydantoin sample subsequent...article 2000
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van Leerdam, F.J.M. (author)The Youth Health Care guideline 'Early screening for hearing impairment, ages 0-19 years' draws the attention of all parties involved to the case finding of, notably, perceptive hearing loss; it helps workers in the Youth Health Care argue their referrals and improve the next steps in the process. Referrals always aim at ruling out perceptive...article 2000
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TNO Preventie en Gezondheid (author), Boomsma, D.I. (author), Beem, A.L. (author), van den Berg, M. (author), Dolan, C.V. (author), Koopmans, J.R. (author), Vink, J.M. (author), de Geus, E.J.C. (author), Slagboom, P.E. (author)In a longitudinal study of Dutch adolescent and young adult twins, their parents and their siblings, questionnaire data were collected on depression, anxiety and correlated personality traits, such as neuroticism. Data were collected by mailed surveys in 1991, 1993, 1995 and 1997. A total of 13 717 individuals from 3344 families were included in...article 2000
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van Wouwe, J.P. (author), Dandachli, T.H. (author), Huber, J. (author), TNO Preventie en Gezondheid (author)Wiegendood is een ingrijpende gebeurtenis voor ouders en hulpverleners. Als een kind jonger dan 2 jaar plotseling levenloos wordt aangetroffen, vraagt iedereen zich af: ‘Hoe kon dit gebeuren?’ Kennis over oorzaken van wiegendood is enerzijds gebaseerd op epidemiologische analyse van de gevallen, anderzijds op bevindingen verkregen bij...article 1999
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van den Berg, H. (author), van Vliet, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The effects of lutein and lycopene on β-carotene absorption and cleavage were investigated in 12 male subjects. Responses of carotenoids and retinyl palmitate in the triacylglycerol-rich lipoprotein (TRL) fraction after a separate 15-mg β-carotene dose were compared with those after a dose of 15 mg β-carotene combined with 15 mg lycopene or...article 1998