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Heinen, M.M. (author), Verhage, B.A.J. (author), Lumey, L.H. (author), Brants, H.A.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Background: Recent studies of pancreatic cancer suggest a role for hyperinsulinemia in carcinogenesis. Because insulin is secreted in response to elevated blood glucose concentrations, dietary factors that increase these concentrations may be important in pancreatic carcinogenesis. Objective: The objective was to examine prospectively the...article 2008
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TNO Kwaliteit van Leven (author), Grote, F.K. (author), Oostdijk, W. (author), de Muinck Keizer-Schrama, S.M.P.F. (author), van Dommelen, P. (author), van Buuren, S. (author), Dekker, F.W. (author), Ketel, A.G. (author), Moll, H.A. (author), Wit, J.M. (author)Background: As abnormal growth might be the first manifestation of undetected diseases, it is important to have accurate referral criteria and a proper diagnostic work-up. In the present paper we evaluate the diagnostic work-up in secondary health care according to existing consensus guidelines and study the frequency of underlying medical...article 2008
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TNO Defensie en Veiligheid (author), Neerincx, M.A. (author), Lindenberg, J. (author), Smets, N.J.J.M. (author), Bos, A. (author), Breebaart, L. (author), Grant, T. (author), Olmedo-Soler, A. (author), Brauer, U. (author), Wolff, M. (author)Manned long-duration missions to the Moon and Mars set high operational, human factors and technical demands for a distributed support system, which enhances human-machine teams' capabilities to cope autonomously with unexpected, complex and potentially hazardous situations. Based on a situated Cognitive Engineering (sCE) method, we specified a...conference paper 2008
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van Laar, J.J.N. (author), Grishchenko, M. (author), van Wouwe, J.P. (author), Stronks, K. (author), TNO Kwaliteit van Leven (author)Aims: Little is known about ethnic differences in the timely diagnosis of Type 1 diabetes mellitus (Type 1 DM). This study aimed to assess ethnic inequalities in the timely diagnosis of Type 1 DM, as indicated by a more adverse clinical condition at onset. In addition, we assessed whether these differences could be explained by differences in...article 2007
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Verhage, B.A.J. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Using data collected of a large population-based cohort study, we studied the association between anthropometric factors and the risk of pancreatic cancer. Furthermore, we investigated whether these associations differ among microscopically confirmed pancreatic cancer (MCPC) cases and non-MCPC (NMCPC) cases. The Netherlands Cohort Study on Diet...article 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.P.H.T.M. (author), Horbach, G.J. (author), Smit, M.J. (author), Zandberg, P. (author), Mellema, J.R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were administered at five single oral dosages between 2 and 500 mg/kg and between 6 and 1800 mg/kg,...article 2007
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Jacobusse, G. (author), van Buuren, S. (author), TNO Kwaliteit van Leven (author)Developmental indicators that are used for routine measurement in The Netherlands are usually chosen to optimally identify delayed children. Measurements on the majority of children without problems are therefore quite imprecise. This study explores the use of computerized adaptive testing (CAT) to monitor the development of young children. CAT...article 2007
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Einhorn, R. (author), van Eekhof, J.A.H. (author), Engelberts, A.C. (author), Groeneveld, Y. (author), Verkerk, P.H. (author), Wit, J.M. (author), TNO Kwaliteit van Leven (author)Background: In the Netherlands, preventive child health service (CHS) screening plays an important role in the early detection of congenital, developmental, physical, and mental disorders. Objective: To obtain insight into the referral patterns of children from CHS to general practitioners and from general practitioners to medical specialists....article 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.-P.H.T.M. (author), Smit, M.J. (author), Zandberg, P. (author), Horbach, G.J. (author), Mellema, J.-R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference compounds and one nontoxic control compound (mianserine) in rats. The toxic compounds are...article 2007
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- Hekkenberg, R.T. (author), Beissner, K. (author), Zeqiri, B. (author), Richards, A. (author), Bezemer, R.A. (author), Hodnett, M. (author) book 2007
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TNO Kwaliteit van Leven (author), Grote, F.K. (author), Oostdijk, W. (author), de Muinck Keizer-Schrama, S.M.P.F. (author), Dekker, F.W. (author), van Dommelen, P. (author), van Buuren, S. (author), Lodder-van der Kooij, A.M. (author), Verkerk, P.H. (author), Wit, J.M. (author)Background. To promote early diagnosis and treatment of short stature, consensus meetings were held in the mid nineteen nineties in the Netherlands and the UK. This resulted in guidelines for referral. In this study we evaluate the referral pattern of short stature in primary health care using these guidelines, comparing it with cut-off values...article 2007
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Breuning-Boers, J.M. (author), van Dommelen, P. (author), van Wouwe, J.P. (author), Verkerk, P.H. (author)Objective. To determine the relationship between serum sodium concentration and weight loss as well as residual symptoms in newborns with hypernatremic dehydration caused by insufficient breastfeeding; and to determine the sensitivity of the following rule of thumb 'if weight loss is less than 10%, the baby does not have hypernatremic...article 2006
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Serov, A.N. (author), Nieland, J. (author), Oosterbaan, S. (author), Steenbergen, W. (author), Bekman, H.H.P.T. (author), de Mul, F.F.M. (author), van Kranenburg, H. (author), TNO Defensie en Veiligheid (author)An integrated optoelectronic probe with small dimensions, for direct-contact laser Doppler blood flow monitoring has been realized. A vertical cavity surface emitting laser (VCSEL), and a chip with photodetectors and all necessary electronics are integrated in a miniature probe head connected to a laptop computer. The computer sound processor is...article 2006
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TNO Defensie en Veiligheid (author), Noort, D. (author), van der Schans, M.J. (author), Benschop, H.P. (author)An overview is presented of the major methods that are presently available for biomonitoring of exposure to chemical warfare agents, i.e., nerve agents and sulfur mustard. These methods can be applied for a variety of purposes such as diagnosis and dosimetry of exposure of casualties, verification of nonadherence to the Chemical Weapon...bookPart 2006
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Lanting, C.I. (author), van Tijn, D.A. (author), Loeber, J.G. (author), Vulsma, T. (author), de Vijlder, J.J.M. (author), Verkerk, P.H. (author), TNO Preventie en Gezondheid (author)Context. Since the introduction of screening for congenital hypothyroidism (CH) in 1974, the optimal laboratory strategy has been the subject of debate. Objective. To assess the clinical effectiveness and cost-effectiveness of various types of thyroxine (T4)-based strategies to screen for CH. Design, Setting, and Participants. In the Netherlands...article 2005
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Lintsen, A.M.E. (author), de Pasker-Jong, P.C.M. (author), de Boer, E.J. (author), Burger, C.W. (author), Jansen, C.A.M. (author), Braat, D.D.M. (author), van Leeuwen, F.E. (author), Kortman, M. (author), te Velde, E.R. (author), Macklon, N. (author), Jansen, C.A.M. (author), Leerentveld, R.A. (author), Willemsen, W.N.P. (author), Schats, R. (author), Naaktgeboren, N. (author), Helmerhorst, F.M. (author), Bots, R.S.G.M. (author), Simons, A.H.M. (author), Hogerzeil, H.V. (author), Evers, J.L.H. (author), van Dop, P.A. (author), TNO Kwaliteit van Leven (author)Background: We investigated the separate and combined effects of smoking and body mass index (BMI) on the success rate of IVF for couples with different causes of subfertility. Methods: The success rate of IVF was examined in 8457 women. Detailed information on reproduction and lifestyle factors was combined with medical record data on IVF...article 2005
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Trion, A. (author), de Maat, M.P.M. (author), Jukema, J.W. (author), van der Laarse, A. (author), Maas, M.C. (author), Offerman, E.H. (author), Havekes, L.M. (author), Szalai, A.J. (author), Princen, H.M.G. (author), Emeis, J.J. (author), TNO Kwaliteit van Leven (author)Objective - C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development of atherosclerosis. Mouse CRP is not expressed at high levels under normal conditions and increases in concentration only several-fold during an acute phase response. Because the...article 2005
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van der Greef, J. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)The pharmaceutical industry is currently beleaguered by close scrutiny from the financial community, regulators and the general public. Productivity, in terms of new drug approvals, has generally been falling for almost a decade and the safety of a number of highly successful drugs has recently been brought into question. Here, we discuss...article 2005
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Grote, F.K. (author), Oostdijk, W. (author), de Muinck Keizer-Schrama, S.M.P.F. (author), Dekker, F.W. (author), Verkerk, P.H. (author), Wit, J.M. (author), TNO Kwaliteit van Leven (author), KvL (author)Background/Aims: Growth monitoring is almost universally performed, but few data are available on which referral criteria and diagnostic work-up are used worldwide for children with short stature. Methods: A short questionnaire, containing questions on auxological screening and on diagnostic criteria for short stature, was sent to all members of...article 2005
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Wieringa, F.P. (author), Mastik, F. (author), van der Steen, A.F.W. (author), TNO Kwaliteit van Leven (author)We describe a route toward contactless imaging of arterial oxygen saturation (SpO2) distribution within tissue, based upon detection of a two-dimensional matrix of spatially resolved optical plethysmographic signals at different wavelengths. As a first step toward SpO 2-imaging we built a monochrome CMOS-camera with apochromatic lens and 3λ-LED...article 2005