Searched for: subject%3A%22Diagnosis%22
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Balvers, M. (author), Gordijn, I.F. (author), Voskamp-Visser, A.I. (author), Schelling M.F.A., (author), Schuurman, R. (author), Heikens, E. (author), Braakman, R. (author), Stingl, C. (author), van Leeuwen, H.C. (author), Luider, T.M. (author), Dekker, L.J. (author), Levin, E. (author), Paauw, A. (author)
Objectives: Shotgun proteomics is a generic method enabling detection of multiple viral species in one assay. The reliable and accurate identification of these viral species by analyzing peptides from MS-spectra is a challenging task. The aim of this study was to develop an easy accessible proteome analysis approach for the identification of...
article 2023
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de Wilde, J. (author), van Dommelen, P. (author), van Dijk, O. (author), Verkerk, P. (author)
AIMS: An important goal of monitoring developmental milestones is the early identification of a wide range of disorders that affect child development. Duchenne muscular dystrophy (DMD) is generally detected late and therefore treated late, but previous research showed that more DMD boys fail to attain certain milestones than the general...
conference paper 2022
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Schoonderwoerd, T.A.J. (author), Jorritsma, W. (author), Neerincx, M.A. (author), van den Bosch, K. (author)
Much of the research on eXplainable Artificial Intelligence (XAI) has centered on providing transparency of machine learning models. More recently, the focus on human-centered approaches to XAI has increased. Yet, there is a lack of practical methods and examples on the integration of human factors into the development processes of AI-generated...
article 2021
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Li, A. (author), Chen, L. (author), Thomas, R.Z. (author), van der Velden, U. (author), Amaliya, A. (author), van der Sluis, L.W.M. (author), Schuller, A.A. (author), Tjakkes, G.H.E. (author)
Objectives: The reasons for tooth extraction are rarely recorded in epidemiological datasets. It poses a diagnostic challenge to determine if tooth loss is related to periodontal disease (TLPD). The present study aimed to assess the inter-tooth relationships based on the periodontal characteristics of existing teeth. Methods: A cross-sectional...
article 2021
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van Baardewijk, J.U. (author), Agarwal, S. (author), Cornelissen, A.S. (author), Joosen, M.J.A. (author), Kentrop, J. (author), Varon, C. (author), Brouwer, A.M. (author)
Early detection of exposure to a toxic chemical, e.g., in a military context, can be life-saving. We propose to use machine learning techniques and multiple continuously measured physiological signals to detect exposure, and to identify the chemical agent. Such detection and identification could be used to alert individuals to take appropriate...
article 2021
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Otten, W. (author), de Hoogh, H. (author), van den Broek, T. (author), Kalkman, G. (author), Krijger, J.M. (author)
public lecture 2019
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Otten, W. (author), de Hoogh, H. (author), van den Broek, T. (author), Kalkman, G. (author), Krijger, J.M. (author)
conference paper 2019
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Otten, W. (author), de Hoogh, I.M. (author), van Keulen, H. (author), Krijger, J.M. (author), van Dijk, K. (author), Berbée, S. (author), van Empelen, P. (author)
Poster Wednesday Session 3 (Policy & Practice, Research and Teaching)’, inclusief poster abstract.
conference paper 2019
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Stiebing, C. (author), Schie, I.W. (author), Knorr, F. (author), Schmitt, M. (author), Keijzer, N. (author), Kleemann, R. (author), Jahn, I.J. (author), Jahn, M. (author), Kiliaan, A.J. (author), Ginner, L. (author), Lichtenegger, A. (author), Drexler, W. (author), Leitgeb, R.A. (author), Popp, J. (author)
Retinal diseases, such as age-related macular degeneration, are leading causes of vision impairment, increasing in incidence worldwide due to an aging society. If diagnosed early, most cases could be prevented. In contrast to standard ophthalmic diagnostic tools, Raman spectroscopy can provide a comprehensive overview of the biochemical...
article 2019
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Borth, M. (author), Barbini, L. (author)
Predictive maintenance strategies which estimate remaining useful life of system components ensure reliable availability of assets and low total costs of ownership by preventing breakdowns and down-times with timely and well-scheduled maintenance. The focus on the components’ life times falls short, however, to infer the system-level capability...
conference paper 2019
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de Vet, H.C.W. (author), Mullender, M.G. (author), Eekhout, I. (author)
Objective: The concept of specific agreement (SA) has been proposed for dichotomous outcomes for two or more raters. We aim to extend this concept for variables with more than two ordinal or nominal categories and more than two raters. Study Design and Setting: We used two data sets: four plastic surgeons classifying photographs after breast...
article 2018
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van Koppen, A. (author), Verschuren, L. (author), van den Hoek, A.M. (author), Verheij, J. (author), Morrison, M.C. (author), Li, K. (author), Nagabukuro, H. (author), Costessi, A. (author), Caspers, M.P.M. (author), van den Broek, T.J. (author), Sagartz, J. (author), Kluft, C. (author), Beysen, C. (author), Emson, C. (author), van Gool, A.J. (author), Goldschmeding, R. (author), Stoop, R. (author), Bobeldijk-Pastorova, I. (author), Turner, S.M. (author), Hanauer, G. (author), Hanemaaijer, R. (author)
Background & Aims: The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynamics of key molecular processes involved in NASH and to rank early markers for...
article 2017
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He, M. (author), Sun, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), van Wijk, R. (author), Wang, Z. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)
To present the possibilities pertaining to linking ultra-weak photon emission (UPE) with Chinese medicine-based diagnostics principles, we conducted a review of Chinese literature regarding UPE with respect to a systems view of diagnostics. Data were summarized from human clinical studies and animal models published from 1979 through 1998. The...
article 2016
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van Loon, K. (author), Breteler, M.J.M. (author), van Wolfwinkel, L. (author), Rheineck Leyssius, A.T. (author), Kossen, A.S. (author), Kalkman, C.J. (author), van Zaane, B. (author), Peelen, L.M. (author)
Altered respiratory rate is one of the first symptoms of medical conditions that require timely intervention, e.g., sepsis or opioid-induced respiratory depression. To facilitate continuous respiratory rate monitoring on general hospital wards a contactless, non-invasive, prototype monitor was developed using frequency modulated continuous wave...
article 2016
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van der Ploeg, C.P.B. (author), van den Akker-van Marle, M.E. (author), Vernooij-van Langen, A.M.M. (author), Elvers, L.H. (author), Gille, J.J.P. (author), Verkerk, P.H. (author), Dankert-Roelse, J.E. (author), Loeber, J.G. (author), Triepels, R.H. (author), van der Pal, S.M. (author), Dompeling, E. (author), Pals, G. (author), Gulmans, V.A.M. (author), Oey-Spauwen, M.J.W. (author), Wijnands, Y.H.H.M. (author), Castricum, L.M. (author), Arets, H.G.M. (author), van der Ent, C.K. (author), Tiddens, H.A.W.M. (author), de Rijke, Y.B. (author), Yntema, J.B. (author)
BACKGROUND: Previous cost-effectiveness studies using data from the literature showed that newborn screening for cystic fibrosis (NBSCF) is a good economic option with positive health effects and longer survival. METHODS: We used primary data to compare cost-effectiveness of four screening strategies for NBSCF, i.e. immunoreactive trypsinogen...
article 2015
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Velikova, M. (author), Dutra, I. (author), Burnside, E.S. (author)
The development and use of computerized decision-support systems in the domain of breast cancer has the potential to facilitate the early detection of disease
bookPart 2015
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Majchrzykiewicz-Koehorst, J.A. (author), Heikens, E. (author), Trip, H. (author), Hulst, A.G. (author), de Jong, A.L. (author), Viveen, M.C. (author), Sedee, N.J.A. (author), van der Plas, J. (author), Coenjaerts, F.E.J. (author), Paauw, A. (author)
The rapid identification of existing and emerging respiratory viruses is crucial in combating outbreaks and epidemics. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid and reliable identification method in bacterial diagnostics, but has not been used in virological diagnostics. Mass...
article 2015
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Kamphuis, M. (author), van de Nieuwegiessen, A.I. (author), Span, P.M. (author)
Background Dutch Youth health care is an easily accessible service where parents can ask for support for the healthy development of their children. The majority of the screenings and medical examinations show no abnormalities. Sometimes there is doubt about the severity of symptoms: the line between healthy variation and diseases or...
article 2014
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Majchrzykiewicz-Koehorst, J.A. (author), Heikens, E. (author), Trip, H. (author), Hulst, A.G. (author), de Jong, A.L. (author), Viveen, M.C. (author), Sedee, N.J.A. (author), van der Plas, J. (author), Coenjaerts, F.E.J. (author), Paauw, A. (author)
Tested respiratory viruses: influenza A virus, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), were successfully identified directly from crude cell cultures using liquid chromatography-tandem MS (LC-MS/MS). The identification was preceded with the simple, generic and fast sample preparation method. The determined...
conference paper 2014
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Vernooij-van Langen, A.M.M. (author), van der Pal, S.M. (author), Reijntjens, A.J.T. (author), Loeber, J.G. (author), Dompeling, E. (author), Dankert-Roelse, J.E. (author)
Background: False-positive screening results in newborn screening for cystic fibrosis may lead to parental stress, family relationship problems and a changed perception of the child's health. Aim of the study: To evaluate whether parental anxiety induced by a false positive screening result disappears after six months and to assess whether a...
article 2014
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