Searched for: subject%3A%22Diabetes%255C%2Bmellitus%255C%2Btype%255C%2B1%22
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Bodin, J. (author), Kocbach Bølling, A. (author), Wendt, A. (author), Eliasson, L. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)
Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development of diabetes in non-obese diabetic (NOD) mice. Here, we hypothesized that...
article 2015
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Bodin, J. (author), Bølling, A.B. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)
Diabetes mellitus type 1 is an autoimmune disease with a genetic predisposition that is triggered by environmental factors during early life. Epidemiological studies show that bisphenol A (BPA), an endocrine disruptor, has been detected in about 90% of all analyzed human urine samples. In this study, BPA was found to increase the severity of...
article 2014
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van der Hoeven, B.L. (author), Pires, N.M.M. (author), Warda, H.M. (author), Putter, H. (author), Quax, P.H.A. (author), Schalij, M.J. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)
Diabetes mellitus (DM) is a strong predictor of in-stent restenosis. This may be due to a higher level of vascular inflammation. We hypothesized that diabetic patients will benefit from dexamethasone-eluting stents, since local inflammation and consequently neointimal growth are suppressed and no systemic side effects will occur. Methods: 21...
article 2008
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van Wouwe, J.P. (author), Jacobusse, G. (author), van Buuren, S. (author), TNO Kwaliteit van Leven (author)
article 2008
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van Laar, J.J.N. (author), Grishchenko, M. (author), van Wouwe, J.P. (author), Stronks, K. (author), TNO Kwaliteit van Leven (author)
Aims: Little is known about ethnic differences in the timely diagnosis of Type 1 diabetes mellitus (Type 1 DM). This study aimed to assess ethnic inequalities in the timely diagnosis of Type 1 DM, as indicated by a more adverse clinical condition at onset. In addition, we assessed whether these differences could be explained by differences in...
article 2007
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TNO Kwaliteit van Leven (author), Rotteveel, J. (author), Belksma, E.J. (author), Renders, C.M. (author), Hirasing, R.A. (author), Delemarre-Van de Waal, H.A. (author)
Objective: The worldwide trend towards obesity in childhood is also observed in the Netherlands and one of the consequences may be type 2 diabetes. In this study, we assessed the number of children with type 2 diabetes, diagnosed by paediatricians, in the Netherlands. Methods: In 2003 and 2004 the Dutch Paediatric Surveillance Unit, a nationwide...
article 2007
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Zagers, N.P.A. (author), Pot, M.C.A. (author), van Norren, D. (author)
Our aim was to assess the integrity of the photoreceptors in the fovea, and to measure the optical density of the macular pigment and the eye lens in patients with diabetes mellitus, and to compare the results with those of a group of healthy subjects. The directional and spectral properties of the light reflected from a 1.9 deg field centered...
article 2005
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van Wouwe, J.P. (author), Mattiazzo, G.F. (author), El Mokadem, N. (author), Reeser, H.M. (author), Hirasing, R.A. (author)
Objective. To determine the incidence and characteristics of type-1 diabetes mellitus (DM) in children aged 0-14 years during the period 1996-1999 and to compare this with previous measurements of the incidence. Design. Descriptive. Method. Data were collected via reports from all practicing paediatricians to the Dutch Paediatric Surveillance...
article 2004
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van Wouwe, J.P. (author), Verkerk, P.H. (author), Mattiazzo, G.F. (author), El Mokadem, N. (author), Hirasing, R.A. (author)
article 2002
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van Hogeboom Buggenum, I.M. (author), Polak, B.C.P. (author), Reichert-Thoen, J.W.M. (author), Vries de - Knoppert, W.A.E.J. (author), van Hinsbergh, V.W.M. (author), Tangelder, G.J. (author), Gaubius Instituut TNO (author)
Aims/hypothesis. Vascular endothelial growth factor (VEGF) is thought to be instrumental in the progression of diabetic retinopathy. Indications exist that the renin-angiotensin system is involved in VEGF overexpression. We assessed the vitreous VEGF concentrations in patients and related them to anti-hypertensive treatment, with special...
article 2002
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TNO Preventie en Gezondheid (author), van Maanen, J.M.S. (author), Albering, H.J. (author), de Kok, T.M.C.M. (author), van Breda, S.G.J. (author), Curfs, D.M.J. (author), Vermeer, I.T.M. (author), Ambergen, A.W. (author), Wolffenbuttel, B.H.R. (author), Kleinjans, J.C.S. (author), Reeser, H.M. (author)
In recent years, several studies have addressed a possible relationship between nitrate exposure and childhood type 1 insulin-dependent diabetes mellitus. The present ecologic study describes a possible relation between the incidence of type 1 diabetes and nitrate levels in drinking water in The Netherlands, and evaluates whether the World...
article 2000
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Schalkwijk, C.G. (author), Poland, D.C.W. (author), van Dijk, W. (author), Kok, A. (author), Emeis, J.J. (author), Dräger, A.M. (author), Doni, A. (author), van Hinsbergh, V.W.M. (author), Stehouwer, C.D.A. (author), Gaubius instituut TNO (author)
Moderately increased plasma concentrations of C-reactive protein are associated with an increased risk of cardiovascular disease, C-reactive protein, its relation to a low degree of inflammatory activation and its association with activation of the endothelium have not been systematically investigated in Type I (insulin-dependent) diabetes...
article 1999
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Schalkwijk, C.G. (author), Ligtvoet, N. (author), Twaalfhoven, H. (author), Jager, A. (author), Blaauwgeers, H.G.T. (author), Schlingemann, R.O. (author), Tarnow, L. (author), Parving, H.H. (author), Stehouwer, C.D.A. (author), van Hinsbergh, V.W.M. (author), Gaubius instituut TNO (author)
Nonenzymatic glycation is increased in diabetes. Most studies so far have focused on the role of advanced glycation end products (AGEs) in vascular complications, whereas the role of early glycation Amadori-modified proteins, which is the predominant form of glycated proteins, has not been systemically investigated in humans. We developed an...
article 1999
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Feltkamp, T.E.W. (author), Aarden, L.A. (author), Lucas, C.J. (author), Verweij, C.L. (author), de Vries, R.R.P. (author), TNO Preventie en Gezondheid (author)
In most autoimmune diseases multigenic factors play a significant role in pathogenesis. Progress in identifying these genetic factors, many of which are located outside the major histocompatibility complex, was the subject of a recent meeting. Chemicals/CAS: Interleukin-10, 130068-27-8; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha
article 1999
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Smulders, R.A. (author), Stehouwer, C.D.A. (author), Schalkwijk, C.G. (author), Donker, A.J.M. (author), van Hinsbergh, V.W.M. (author), TeKoppele, J.M. (author), TNO Preventie en Gezondheid (author)
Dysfunction of the vascular endothelium is considered an early step in the development of diabetic angiopathy. Hyperglycaemia results in endothelial dysfunction, both through direct effects of glucose and through formation of advanced glycosylation end-products (AGEs). We hypothesized that the effects of glucose and AGEs on endothelial function...
article 1998
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Myrup, B. (author), Jensen, T. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)
OBJECTIVE - The high risk for cardiovascular disease in IDDM patients with nephropathy may be mediated by abnormal function of the vascular wall. We investigated whether heparin was able to modulate markers of vascular wall and hemostatic function in patients with incipient nephropathy. RESEARCH DESIGN AND METHODS - Thirty-five IDDM patients...
article 1997
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Vos, C. (author), Reeser, H.M. (author), Hirasing, R.A. (author), Bruining, G.J. (author), TNO Preventie en Gezondheid (author)
The incidence of Type 1 (insulin-dependent) diabetes mellitus among Moroccan children aged (0-19 years) in The Netherlands was determined. Point of reference was the data derived from the second nationwide incidence study on Type 1 diabetes among children under 20 years of age. In that study the incidence among Dutch children was 13.2 100000-1...
article 1997
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Tooke, J.E. (author), Shore, A.C. (author), Cohen, R.A. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
article 1996
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Hirasing, R.A. (author), Reeser, H.M. (author), de Groot, R.R.M. (author), Ruwaard, D. (author), van Buuren, S. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)
OBJECTIVE - To determine the number and duration of hospital admissions due to diabetes in children aged 0-19 years between 1980 and 1991. RESEARCH DESIGN AND METHODS - Secondary analysis of data collected by the SIG Health Care Information was based on the 9th revision of the International Classification of Diseases. The subjects were all...
article 1996
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Myrup, B. (author), Hansen, P.M. (author), Jensen, T. (author), Kofoed-Enevoldsen, A. (author), Feldt-Rasmussen, B. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)
We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low...
article 1995
Searched for: subject%3A%22Diabetes%255C%2Bmellitus%255C%2Btype%255C%2B1%22
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