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Mazzucchelli, G. (author), Holzhauser, T. (author), Cirkovic Velickovic, T. (author), Diaz-Perales, A. (author), Molina, E. (author), Roncada, P. (author), Rodrigues, P. (author), Verhoeckx, K. (author), Hoffmann-Sommergruber, K. (author)Food allergies are recognized as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well-known foods and foods containing genetically modified ingredients is installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods,...article 2018
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Weyers, M.M. (author), Bakhuys Roozeboom, M.C. (author), van Egmond, M.P. (author), Franken, R.A. (author), Fransman, W. (author), Hermans, L.M. (author), Huibregtsen, J. (author), Schaddelee-Scholten, B.J.W. (author), Schelvis, R.M.C. (author), Schuilenborg, L. (author), Spaan, S. (author), Venema, A. (author)In Nederland wordt het aantal werknemers dat een door een arts vastgestelde beroepsziekte heeft, geschat op bijna 750.000 (11%). De maatschappelijke kosten van verzuim als gevolg van gezondheidsproblemen door het werk worden geschat op zo’n 8 miljard euro per jaar (Arbobalans 2016). Voorkomen van beroepsziekten levert zowel werkgevers en...report 2018
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Rosca, B. (author), Wilkins, S. (author), Hoedemaekers, E. (author)Model based development methodologies have strong potential in reducing development effort of complex automotive systems. This paper presents a model based development methodology used to develop battery state estimation algorithms, and steps through all the steps required for this. The benefits of the mixed simulation and testing methodology...conference paper 2018
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van Wezel, A.P. (author), van Lente, H. (author), van de Sandt, J.J.M. (author), Bouwmeester, H. (author), Vandeberg, R.L.J. (author), Sips, A.J.A.M. (author)Governments invest in “key enabling technologies,” such as nanotechnology, to solve societal challenges and boost the economy. At the same time, governmental agencies demand risk reduction to prohibit any often unknown adverse effects, and industrial parties demand smart approaches to reduce uncertainties. Responsible research and innovation ...article 2018
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Goede, H.A. (author), Ploeg, D. (author), Schinkel, J.M. (author)The development of a dermal exposure model is a challenge because of the complexity of dermal exposure processes on one hand, and the scarcity of good quality and contextually-rich dermal exposure measurements. Dermal exposure modelling is further complicated by the difficulty of measuring dermal exposure due to the lack of standardised methods ...report 2018
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Jansen-Ferdinandus, G.R. (author), Buiel, E.F.T. (author), Meiler, P.P. (author), Verburgh, T. (author)The increasing labour shortage of skilled ICT personnel forces SOC and CSIRT organisations to prioritize the services they offer and optimise their workforce development strategies. Our review of currently available frameworks shows that there is no single framework that provides a complete solution to identify the required competencies of SOC...report 2018
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van Middelaar, J. (author), Boot, H. (author)Wat is RESPONSE? Bij een incident met gevaarlijke stoffen heeft Response drie functies: 1. Berekenen van de bronlocatie van het incident, onder meer op basis van sensordata of klachten van omwonenden; 2. Berekenen van de mogelijke effecten van het incident met een gevaarlijke stof voor de omgeving; 3. Selecteren van informatie voor werknemers en...other 2018
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- Minnens, F. (author), Sioen, I. (author), van de Brug, F. (author), Lucas Luijckx, N.B. (author) report 2018
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- Lucas Luijckx, N.B. (author) report 2018
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Pronk, A. (author), Stierum, R. (author)Our health is impacted by the environment we grow up, live, work, sport, sleep and relax in. The combination of exposures during daily activities and over the lifetime constitutes a major risk factor for disease. Many common disorders are closely linked to these exposures ranging from lifestyle factors, to chemical exposures, social interactions...other 2018
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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...article 2018
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Zhao, Y. (author), Kumar, M. (author), Caspers, M.P.M. (author), Nierop Groot, M.N. (author), van der Vossen, J.M.B.M. (author), Abee, T. (author)Thermophilic bacilli such as Anoxybacillus and Geobacillus are important contaminants in dairy powder products. Remarkably, one of the common contaminants, Geobacillus thermoglucosidans, showed poor growth in skim milk, whereas significant growth of G. thermoglucosidans was observed in the presence of an Anoxybacillus flavithermus dairy isolate....article 2018
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de Kluizenaar, Y. (author), Kuijpers, E. (author), Eekhout, I. (author), Voogt, M. (author), Vermeulen, R.C.H. (author), Hoek, G. (author), Sterkenburg, R.P. (author), Pierik, F.H. (author), Duyzer, J.H. (author), Meijer, E.W. (author), Pronk, A. (author)Particulate matter exposure may cause adverse health effects. Although ultrafine particulate matter (UFP) is hypothesised to be particularly health relevant, the number of studies into personal UFP exposure is limited. Aim To increase insight where and when most UFP exposure occurs, in terms of exposure levels and peaks in microenvironments,...article 2017
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Mentink, P. (author), Seykens, X. (author), Escobar Valdivieso, D. (author)To meet future emission targets, it becomes increasingly important to optimize the synergy between engine and aftertreatment system. By using an integrated control approach minimal fluid (fuel and DEF) consumption is targeted within the constraints of emission legislation during real-world operation. In such concept, the on-line availability of...article 2017
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Leist, M. (author), Ghallab, A. (author), Graepel, R. (author), Marchan, R. (author), Hassan, R. (author), Bennekou, S.H. (author), Limonciel, A. (author), Vinken, M. (author), Schildknecht, S. (author), Waldmann, T. (author), Danen, E. (author), van Ravenzwaay, B. (author), Kamp, H. (author), Gardner, I. (author), Godoy, P. (author), Bois, F.Y. (author), Braeuning, A. (author), Reif, R. (author), Oesch, F. (author), Drasdo, D. (author), Höhme, S. (author), Schwarz, M. (author), Hartung, T. (author), Braunbeck, T. (author), Beltman, J. (author), Vrieling, H. (author), Sanz, F. (author), Forsby, A. (author), Gadaleta, D. (author), Fisher, C. (author), Kelm, J. (author), Fluri, D. (author), Ecker, G. (author), Zdrazil, B. (author), Terron, A. (author), Jennings, P. (author), van der Burg, B. (author), Dooley, S. (author), Meijer, A.H. (author), Willighagen, E. (author), Martens, M. (author), Evelo, C. (author), Mombelli, E. (author), Taboureau, O. (author), Mantovani, A. (author), Hardy, B. (author), Koch, B. (author), Escher, S. (author), van Thriel, C. (author), Cadenas, C. (author), Kroese, D. (author), van de Water, B. (author), Hengstler, J.G. (author)Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event...article 2017
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Jedynska, A. (author), Hoek, G. (author), Wang, M. (author), Yang, A. (author), Eeftens, M. (author), Cyrys, J. (author), Keuken, M. (author), Ampe, C. (author), Beelen, R. (author), Cesaroni, G. (author), Forastiere, F. (author), Cirach, M. (author), de Hoogh, K. (author), de Nazelle, A. (author), Nystad, W. (author), Akhlaghi, H.M. (author), Declercq, C. (author), Stempfelet, M. (author), Eriksen, K.T. (author), Dimakopoulou, K. (author), Lanki, T. (author), Meliefste, K. (author), Nieuwenhuijsen, M. (author), Yli-Tuomi, T. (author), Raaschou-Nielsen, O. (author), Janssen, N.A.H. (author), Brunekreef, B. (author), Kooter, I.M. (author)Oxidative potential (OP) has been suggested as a health-relevant measure of air pollution. Little information is available about OP spatial variation and the possibility to model its spatial variability. Our aim was to measure the spatial variation of OP within and between 10 European study areas. The second aim was to develop land use...article 2017
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Birot, S. (author), Madsen, C.B. (author), Kruizinga, A.G. (author), Christensen, T. (author), Crépet, A. (author), Brockhoff, P.B. (author)Food allergic subjects need to avoid the allergenic food that triggers their allergy. However, foods can also contain unintended allergens. Food manufacturers or authorities need to perform a risk assessment to be able to decide if unintended allergen presence constitutes a risk to food allergic consumers. One of the input parameters in risk...article 2017
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Eendebak, P.T. (author), Schoen, E.D. (author)We study the design of two-level experiments with N runs and n factors large enough to estimate the interaction model, which contains all the main effects and all the two-factor interactions. Yet, an effect hierarchy assumption suggests that main effect estimation should be given more prominence than the estimation of two-factor interactions....article 2017
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Changing the field of carcinogenicity testing of human pharmaceuticals by emphasizing mode of actionvan der Laan, J.W. (author), Duijndam, B. (author), van den Hoorn, T. (author), Woutersen, R. (author), van de Water, B. (author)Lifetime testing for carcinogenicity of pharmaceuticals in rodents has been a controversial issue since the start of the International Conference on Harmonisation in 1990. Since 2010 the debate reached a new level following the proposal that a negative outcome of carcinogenicity studies can be predicted based upon the findings of 6 months...article 2017
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Ding, D. (author), Burger, F. (author), Brinkman, W.P. (author), Neerincx, M.A. (author)A number of negotiation training systems have been developed to improve people’s performance in negotiation. They mainly focus on the skills development, and less on negotiation understanding and improving self-efficacy. We propose a virtual reality negotiation training system that exposes users to virtual cognitions during negotiation with...conference paper 2017