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Hanea, R.G. (author), Bjorlykke, O.P. (author), Hashmi, Y. (author), Feng, T. (author), Fonseca, R.M. (author)In this paper we present our results, challenges and learnings, over a two-year period wherein robust multi-objective optimization was applied at the Mariner asset which is being currently developed. Many different problems were solved with different objectives. These problems were formulated based on the phases of planning and development at...conference paper 2019
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Houben, G. (author), Blom, M. (author), Alvito, P. (author), Assuncao, R. (author), Crevel, R. (author), Faeste, C.K. (author), Le, T.M. (author), Madsen, C.B. (author), Remington, B. (author), Stroheker, T. (author), Vassilopoulou, E. (author), Verhoeckx, K. (author), Ayiarovska, J. (author), Constable, A. (author)Many food innovations rely on the introduction and use of new or modified proteins. New or modified food proteins may lead to major health risks due to their inherent potential to cause food allergy. Currently, the pre-market allergenicity assessment for new or modified food proteins and protein sources relies on methods for identifying...article 2019
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Dhondt, S. (author), van der Zee, F. (author), Preenen, P. (author), Kraan, K.O. (author), Oeij, P.R.A. (author)This paper describes a new approach to investigating, unraveling and explaining the implications of digital technologies for skills. To do so, the paper develops an approach to assess technology in companies in a more precise way, building on three main arguments. Firstly, current approaches to the subject treat all (new and emerging)...bookPart 2019
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Versluis, A. (author), van Os-Medendorp, H. (author), Blom, W.M. (author), Michelsen-Huisman, A.D. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Houben, G.F. (author), Knulst, A.C. (author)Background: Cofactors, such as physical exercise and alcohol intake, might be associated with the severity or occurrence of food allergic reactions. Objective: To gain insight into the frequency of presence of potential cofactors in accidental food allergic reactions in adults and to what extent these factors influence the severity and...article 2019
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Pali-Scholl, I. (author), Verhoeckx, K. (author), Mafra, I. (author), Bavaro, S.L. (author), Mills, E.N.C. (author), Monaci, L. (author)Background. There is an increasing demand for animal-derived products in the developing countries. This poses major concerns for the sustainable production of safe and nutritious food. Consequently, to address these needs alternative sustainable sources of valuable dietary proteins are sought for. Scope and approach. In this review, we discuss...article 2019
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Genderen, P.V. (author), Stolp, E. (author), Heebels, G. (author)This paper addresses the early developments that have resulted in the design and development of active electronically scanned arrays (AESA) in The Netherlands. An early type of radar measuring the position of objects in range, azimuth and elevation in three dimensions (SPS-01/MTTR) is described in some detail. Requirements of the Royal...conference paper 2019
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Vazquez, A.R. (author), Goos, P. (author), Schoen, E.D. (author)Two-level orthogonal arrays of N runs, k factors, and a strength of 3 provide suitable fractional factorial designs in situations where many of the main effects are expected to be active, as well as some two-factor interactions. If they consist of N/2 mirror image pairs, these designs are fold-over designs. They are called even and provide at...article 2019
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Atukunda, P. (author), Muhoozi, G.K.M. (author), van den Broek, T.J. (author), Kort, R. (author), Diep, L.M. (author), Kaaya, A.N. (author), Iversen, P.O. (author), Westerberg, A.C. (author)Background Undernutrition impairs child development outcomes and growth. In this follow-up study of an open cluster-randomized intervention trial we examined the effects of an education package delivered to mothers in rural Uganda on their children's development, growth and gut microbiota at 36 months of age. Methods The parental trial included...article 2019
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Kuijpers, E. (author), Pronk, A. (author), Koivisto, A.J. (author), Jensen, K.A. (author), Vermeulen, R. (author), Fransman, W. (author)Introduction. Knowledge on the exposure characteristics, including release of nanomaterials, is especially needed in the later stages of nano-enabled products’ life cycles to perform better occupational risk assessments. The objective of this study was to assess the concentrations during sawing and drilling in car bumpers containing multi-walled...article 2019
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Diepeveen, F.B. (author)Specific language impairment (SLI), or developmental language disorder, is the most prevalent development disorder in childhood. However, most children with SLI are detected late. Predictive properties of language milestones and risk factors for having SLI later in life were investigated in a nested case-control study. The outcomes showed that...doctoral thesis 2019
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Schinkel, J. (author), Heerderik, D. (author), Helsloot, I. (author), Kraaijenbrink, S. (author), Vis, J. (author)In veel situaties is momenteel onduidelijk wat de blootstelling aan asbest (door inhalatie) werkelijk is, en daarmee wat de bijbehorende gezondheidsrisico’s zijn. Hierdoor is het dus veelal niet mogelijk om vast te stellen wat proportionele veiligheidsmaatregelen zijn.report 2019
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Ediati, A. (author), Verrips, G.H.W. (author), Juniarto, A.Z. (author), Faradz, S.M.H. (author), Drop, S.L.S. (author), Dessens, A.B. (author)Background:Patients with a disorder of sex development (DSD) are born with atypical genitals or may develop atypical genitals and atypical body appearance, if left untreated. Health related quality of life (HRQoL) was assessed in Indonesian patients to whom diagnostic procedures and medical intervention had been delayed. Method: Comparison of...article 2019
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Vlasblom, E. (author), Boere-Boonekamp, M.M. (author), Hafkamp-de Groen, E. (author), Dusseldorf, E. (author), van Dommelen, P. (author), Verkerk, P.H. (author)Developmental milestones are commonly used in child health care, although from many milestones the predictive validity has not been adequately assessed. We aimed to determine the predictive validity of 75 developmental milestones for detecting limited intellectual functioning that can be obtained before the age of 4 years. We performed a case...article 2019
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Semenzina, E. (author), Subramanian, V. (author), Pizzo, L. (author), Zabeo, A. (author), Fransman, W. (author), Oksel, C. (author), Hristozov, D. (author), Marcomini, A. (author)The widespread use of engineered nanomaterials (ENMs) in consumer products and the overwhelming uncertainties in their ecological and human health risks have raised concerns regarding their safety among industries and regulators. There has been an ongoing debate over the past few decades on ways to overcome the challenges in assessing and...article 2019
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- QuSoft, QT/e, NWO, het Lorentz Instituut, AMS-IX, StartupDelta en Microsoft, m.m.v. EZK TNO, QuTech, (author) report 2019
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Weber, A.M. (author), Rubio-Codina, M. (author), Walker, S.P. (author), van Buuren, S. (author), Eekhout, I. (author), Grantham-Mcgregor, S.M. (author), Araujo, M.C. (author), Chang, S.M. (author), Fernald, L.C.H. (author), Hamadani, J.D. (author), Hanlon, C. (author), Karam, S.M. (author), Lozoff, B. (author), Ratsifandrihamanana, L. (author), Richter, L. (author), Black, M.M. (author)Introduction Early childhood development can be described by an underlying latent construct. Global comparisons of children's development are hindered by the lack of a validated metric that is comparable across cultures and contexts, especially for children under age 3 years. We constructed and validated a new metric, the Developmental Score (D...article 2019
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Huijs, J.J.J.M. (author), Houtman, I.L.D. (author), Blonk, R.W.B. (author)Background. The aim of this study is to develop a new measure for the concept of mental retirement and test the construct validity of the measure. Employees who are ‘mentally retired’ are present at their work physically, but have already said their goodbyes mentally. Mental retirement has a three-factor structure: developmental proactivity,...article 2019
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Derks, M.J.W. (author), Romijn, H. (author)Rural off-grid electrification systems powered by renewable energy have become popular in the Global South. Unfortunately, many microgrids have experienced trouble during their first years of operation, leading to premature system deterioration. In this paper we trace these problems to institutional issues associated with goal displacement in...article 2019
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Nagele, T. (author), Broenink, T. (author), Hooman, J. (author), Broenink, J. (author)The multi-disciplinary nature of the design of cyber-physical systems makes it hard to gain insight in the system behaviour early in the design process. Our aim is to allow the designers to analyse the integration of system components as well as the behaviour of the complete system in an early stage. This is achieved by creating abstract...conference paper 2019
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Savic, N. (author), Gasic, B. (author), Schinkel, J. (author), Vernez, D. (author)The Advanced REACH Tool (ART) is the most sophisticated tool used for evaluating exposure levels under the European Union's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulations. ART provides estimates at different percentiles of exposure and within different confidence intervals (CIs). However, its performance...article 2018