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Huovila, A. (author), Bosch, P.R. (author), Airaksinen, M. (author)City managers need indicators for target setting, performance assessment, monitoring, management and decision-making purposes. The choice of the most suitable indicator framework is crucial, but difficult, as it requires expert knowledge. To help cities in their choice, this paper compares seven recently published indicator standards for Smart...article 2019
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Eichstädt, S. (author), van der Waaij, B.D. (author), Ludwig, B. (author), Langius, E. (author)Transparency of changes, automated testing of new developments against documented criteria, combination of developments from different sources and automated publication of validated results are key aspects of modern collaborative software engineering. Various infrastructures, guidelines and tools are available for continuous integration (CI) and...conference paper 2019
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Scherer, L. (author), de Koning, A. (author), Tukker, A. (author)The BRIC (Brazil, Russia, India, China) and MINT countries (Mexico, Indonesia, Nigeria, Turkey) shifted the economic weight from developed to emerging countries. They will continue to grow rapidly by population and gross domestic product (GDP), which could also imply environmental changes. We use the environmentally extended multi-regional input...article 2019
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Toet, A. (author), Heijn, F. (author), Brouwer, A.M. (author), Mioch, T. (author), van Erp, J.B.F. (author)Immersive 360° VR systems are increasingly used in entertainment, marketing and design and development processes. Many of these applications involve emotional experiences. Since momentary emotions significantly determine a user’s response and decisions, it is essential to understand the influence of media content and technological factors on the...article 2019
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Kuiper, S. (author), Kramer, L. (author), Kooper, M. (author), Crowcombe, W.E. (author)TNO’s is developing Coarse Pointing Assembly technology aimed at the needs for future laser communication systems.other 2019
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Saberi, A.K. (author), Vissers, J. (author), Benders, F.P.A. (author)Initiatives such as smart mobility and automated driving bring new concerns such as safety and security for the automotive industry. New architecture and designs are required for the in-vehicle systems to address these emerging concerns. Early design decisions have a large impact on the required functionalities as well as the quality attributes...conference paper 2019
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Pizzol, L. (author), Hristozov, D. (author), Zabeo, A. (author), Gianpietro, B. (author), Wohlleben, W. (author), Koivisto, A.J. (author), Jensen, K.A. (author), Fransman, W. (author), Stone, V. (author), Marcomini, A. (author)The increasing use of engineered nanomaterials (ENMs) in nano-enabled products (NEPs) has raised societal concerns about their possible health and ecological implications. To ensure a high level of human and environmental protection it is essential to properly estimate the risks of these new materials and to develop adequate risk management...article 2019
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Masin, M. (author), Palumbo, F. (author), Adriaanse, J. (author), Myrhaug, H. (author), Regazzoni, F. (author), Sanchez, M. (author), Zedda, K. (author)Technical Requirements (TRs) provide a “black box” conceptualization of the target project results with explicit verification tests. The goal of Technical Requirements Elicitation (TRE) is to ensure that all needs of involved stakeholders are being identified and adequately addressed without prescribing how to achieve them. Whilst TRE...conference paper 2019
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van Diggelen, J. (author), Neerincx, M.A. (author), Peeters, M. (author), Schraagen, J.M. (author)Human-agent teams exhibit emergent behavior at the team level, as a result of interactions between individuals within the team. This begs the question how to design artificial team members (agents) as adequate team players that contribute to the team processes advancing team performance, resilience, and learning. This paper proposes the...article 2019
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Mentink, P. (author), Seykens, X. (author)Complying to both the increasingly stringent pollutant emissions as well as (future) GHG emission legislation - with increased focus on in-use real-world emissions - puts a great challenge to the engine/aftertreatment control development process. Control system complexity, calibration and validation effort has increased dramatically over the...conference paper 2019
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Lozano-Ojalvo, D. (author), Benede, S. (author), Antunes, C.M. (author), Bavaro, S.L. (author), Bouchaud, G. (author), Costa, A. (author), Denery-Papini, S. (author), Diaz-Perales, A. (author), Garrido-Arandia, M. (author), Gavrovic-Jankulovic, M. (author), Hayen, S. (author), Martinez-Blanco, M. (author), Molina, E. (author), Monaci, L. (author), Pieters, R.H.H. (author), Villemin, C. (author), Wichers, H.J. (author), Wroblewska, B. (author), Willemsen, L.E.M. (author), Roggen, E.L. (author), van Bilsen, J.H.M. (author)Background: Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety. We have recently proposed the adverse outcome pathway (AOP) concept to structure the current mechanistic understanding of the...article 2019
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Man, W.H. (author), Clerc, M. (author), de Steenhuijsen Piters, W.A.A. (author), van Houten, M.A. (author), Chu, M.L.J.N. (author), Kool, J. (author), Keijser, B.J.F. (author), Sanders, E.A.M. (author), Bogaert, D. (author)Rationale: The respiratory microbiota is increasingly being appreciated as an important mediator in the susceptibility to childhood respiratory tract infections (RTIs). Pathogens are presumed to originate from the nasopharyngeal ecosystem. Objectives: To investigate the association between early life respiratory microbiota and development of...article 2019
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Hanea, R.G. (author), Bjorlykke, O.P. (author), Hashmi, Y. (author), Feng, T. (author), Fonseca, R.M. (author)In this paper we present our results, challenges and learnings, over a two-year period wherein robust multi-objective optimization was applied at the Mariner asset which is being currently developed. Many different problems were solved with different objectives. These problems were formulated based on the phases of planning and development at...conference paper 2019
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Houben, G. (author), Blom, M. (author), Alvito, P. (author), Assuncao, R. (author), Crevel, R. (author), Faeste, C.K. (author), Le, T.M. (author), Madsen, C.B. (author), Remington, B. (author), Stroheker, T. (author), Vassilopoulou, E. (author), Verhoeckx, K. (author), Ayiarovska, J. (author), Constable, A. (author)Many food innovations rely on the introduction and use of new or modified proteins. New or modified food proteins may lead to major health risks due to their inherent potential to cause food allergy. Currently, the pre-market allergenicity assessment for new or modified food proteins and protein sources relies on methods for identifying...article 2019
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Dhondt, S. (author), van der Zee, F. (author), Preenen, P. (author), Kraan, K.O. (author), Oeij, P.R.A. (author)This paper describes a new approach to investigating, unraveling and explaining the implications of digital technologies for skills. To do so, the paper develops an approach to assess technology in companies in a more precise way, building on three main arguments. Firstly, current approaches to the subject treat all (new and emerging)...bookPart 2019
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Versluis, A. (author), van Os-Medendorp, H. (author), Blom, W.M. (author), Michelsen-Huisman, A.D. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Houben, G.F. (author), Knulst, A.C. (author)Background: Cofactors, such as physical exercise and alcohol intake, might be associated with the severity or occurrence of food allergic reactions. Objective: To gain insight into the frequency of presence of potential cofactors in accidental food allergic reactions in adults and to what extent these factors influence the severity and...article 2019
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Pali-Scholl, I. (author), Verhoeckx, K. (author), Mafra, I. (author), Bavaro, S.L. (author), Mills, E.N.C. (author), Monaci, L. (author)Background. There is an increasing demand for animal-derived products in the developing countries. This poses major concerns for the sustainable production of safe and nutritious food. Consequently, to address these needs alternative sustainable sources of valuable dietary proteins are sought for. Scope and approach. In this review, we discuss...article 2019
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Genderen, P.V. (author), Stolp, E. (author), Heebels, G. (author)This paper addresses the early developments that have resulted in the design and development of active electronically scanned arrays (AESA) in The Netherlands. An early type of radar measuring the position of objects in range, azimuth and elevation in three dimensions (SPS-01/MTTR) is described in some detail. Requirements of the Royal...conference paper 2019
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Vazquez, A.R. (author), Goos, P. (author), Schoen, E.D. (author)Two-level orthogonal arrays of N runs, k factors, and a strength of 3 provide suitable fractional factorial designs in situations where many of the main effects are expected to be active, as well as some two-factor interactions. If they consist of N/2 mirror image pairs, these designs are fold-over designs. They are called even and provide at...article 2019
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Atukunda, P. (author), Muhoozi, G.K.M. (author), van den Broek, T.J. (author), Kort, R. (author), Diep, L.M. (author), Kaaya, A.N. (author), Iversen, P.O. (author), Westerberg, A.C. (author)Background Undernutrition impairs child development outcomes and growth. In this follow-up study of an open cluster-randomized intervention trial we examined the effects of an education package delivered to mothers in rural Uganda on their children's development, growth and gut microbiota at 36 months of age. Methods The parental trial included...article 2019