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Deurloo, J. (author), Huizing, A. (author), van der Harst, S. (author), de Wilde, J. (author), van Dommelen, P. (author), Verkerk, P. (author)Aims The Dutch Development Instrument (DDI; in Dutch: Van Wiechenonderzoek) is used in the Dutch Youth Health Care (YHC) to monitor child development from birth to the age of 4 years. Reference values for the DDI, which indicate that approximately 90% of children achieve each milestone at the recommended age, were published in 1981. Aim of this...conference paper 2022
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Eekhout, I. (author), van Buuren, S. (author), Verkerk, P. (author)There are many milestones available to measure child development in the first years of life. For less experienced professionals it is difficult to select the most relevant milestones to assess the developmental status of a child. Moreover, using the milestones separately makes is difficult to get a global impression of the developmental status....public lecture 2022
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Eekhout, I. (author), van Buuren, S. (author)Session Keynote. Healthy growth and development in young children are essential for their future well-being. Professionals and parents consider it necessary to monitor children’s development. While we can track the child’s physical growth by growth charts to identify children with signs of potential delay, there are no charts for monitoring...public lecture 2022
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- Geurts, A. (author), Geerdink, T. (author), Sprenkeling, M. (author) article 2022
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Preuhs, K. (author), van Keulen, H. (author), Andree, R. (author), Wins, S. (author), van Empelen, P. (author)Background: Many parents frequently struggle with undesirable or problematic behavior (ie, temper tantrums and whining) displayed by their child. To support parents in promoting positive parenting skills (ie, recognizing challenging situations and reacting appropriately), the interactive video e-learning tool ParentCoach was developed. The tool...article 2022
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Pan, W. (author), Bekdemir, C. (author), Willems, F. (author)A model-based control approach is proposed to give proper reference for the feed-forward combustion control of Partially Pre-mixed Combustion (PPC) engines. The current study presents a simplified first principal model, which has been developed to provide a base estimation of the ignition properties. This model is used to describe the behavior...conference paper 2022
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van Sandt, H. (author)TNO stands for excellent biomedical research, focusing on the efficacy and safety of medicines. In some cases, animal testing is needed to understand the processes involved in disease development and progression and to study the effects of interventions on these diseases. In doing so, the laboratory animal is seen as a model for humans, allowing...other 2022
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Ostendorf, R. (author), Erpelinck, S. (author)The Organ-on-a-Chip Early Research Program enables TNO to offer state-of-the-art technologies that help the pharmaceutical industry advance drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model human tissue functioning and accelerate compound development and testing. The Intestinal Epithelial Barrier...other 2022
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Ostendorf, R. (author)The Organ-on-a-Chip Early Research Program (ERP) has enabled TNO to offer a number of state-of-the-art technologies to help pharmaceutical and biotech companies advance and accelerate drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model the workings of human tissue and accelerate compound development...other 2022
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Li, C. (author), Mogollón, J.M. (author), Tukker, A. (author), Dong, J. (author), von Terzi, D. (author), Zhang, C. (author), Steubing, B. (author)Offshore wind energy (OWE) is a cornerstone of future clean energy development. Yet, research into global OWE material demand has generally been limited to few materials and/or low technological resolution. In this study, we assess the primary raw material demand and secondary material supply of global OWE. It includes a wide assortment of...article 2022
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Schadd, M.P.D. (author), Sternheim, A.M. (author), Blankendaal, R.A.M. (author), van der Kaaij, M. (author), Visker, O.H. (author)With recent technological advances, commanders request the support of artificial intelligence (AI)-enabled systems during mission planning. Future AI systems may test a wide range of courses of action (COAs) and use a simulator to test each COA’s effectiveness in a war game. The COA’s effectiveness is however dependent on the commanders’ intent....article 2022
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Diran, D.D.D. (author), Hoekstra, M. (author), van Veenstra, A.F.E. (author)The potential of the use of data to help improve policymaking is increasingly recognized by governments, especially to address societal challenges. One of those societal challenges is the energy transition, which happens for a large part at the local government level. However, within the literature little is known about which type of...conference paper 2022
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Human-centered XAI: Developing design patterns for explanations of clinical decision support systemsSchoonderwoerd, T.A.J. (author), Jorritsma, W. (author), Neerincx, M.A. (author), van den Bosch, K. (author)Much of the research on eXplainable Artificial Intelligence (XAI) has centered on providing transparency of machine learning models. More recently, the focus on human-centered approaches to XAI has increased. Yet, there is a lack of practical methods and examples on the integration of human factors into the development processes of AI-generated...article 2021
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- van den Broeke, M. (author), Devoldere, B.P.E. (author), Creemers, S. (author), Boute, R. (author) article 2021
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Mikunda, T. (author), Brunner, L.G. (author), Skylogianni, E. (author), Garcia Moretz-Sohn Monteiro, J. (author), Rycroft, L.L. (author), Kemper, J. (author)For carbon capture and storage (CCS) to be a truly effective option within the efforts being made to mitigate climate change, it must be sustainable. An assessment is therefore required regarding how the deployment of CCS will positively contribute towards the achievement of the UN’s Sustainable Development Goals (SDGs) by 2030. This assessment...article 2021
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- Lubczynska, M.J. (author), Muetzel, R.L. (author), el Marroun, H. (author), Hoek, G. (author), Kooter, I.M. (author), Thomson, E.M. (author), Hillegers, M. (author), Vernooij, M.W. (author), White, T. (author), Tiemeier, H. (author), Guxens, M. (author) article 2021
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Abeln, E. (author)Developing the right probiotic or compound to restore gut heath can be a long, laborious and inefficient process. With i-screen Restoration (i-screen RS), TNO can accelerate pre-clinical study and selection of the right ingredients and streamline the development process.other 2021
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van Wel, L. (author), van Dommelen, P. (author), Zuurbier, M. (author), Heinen, D. (author), Odink, J. (author), Bezem, J. (author), Verkerk, P.H. (author), Pronk, A. (author), Hoek, G. (author)Air pollution, noise, and green space are important environmental exposures, having been linked to a variety of specific health outcomes. However, there are few studies addressing overall early life development. To assess their effects, associations between developmental milestones for a large population of 0–4-year old children in The...article 2021
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van Driessche, A. (author), van Stel, H.F. (author), Vink, R. (author), Staal, I.I.E. (author)Many adverse situations for parenting and healthy child development can be detected before a child’s birth. The aim of this project was to develop and test an instrument to use in prenatal home visits, to improve the identification of adverse situations and care needs during pregnancy. The preSPARK is based on a valid and reliable broad-scope...article 2021
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- Come Zebra, E.I. (author), van der Windt, H.J. (author), Nhumaio, G. (author), Faaij, A.P.C. (author) article 2021