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Ostendorf, R. (author)The Organ-on-a-Chip Early Research Program (ERP) has enabled TNO to offer a number of state-of-the-art technologies to help pharmaceutical and biotech companies advance and accelerate drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model the workings of human tissue and accelerate compound development...other 2022
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Li, C. (author), Mogollón, J.M. (author), Tukker, A. (author), Dong, J. (author), von Terzi, D. (author), Zhang, C. (author), Steubing, B. (author)Offshore wind energy (OWE) is a cornerstone of future clean energy development. Yet, research into global OWE material demand has generally been limited to few materials and/or low technological resolution. In this study, we assess the primary raw material demand and secondary material supply of global OWE. It includes a wide assortment of...article 2022
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Schadd, M.P.D. (author), Sternheim, A.M. (author), Blankendaal, R.A.M. (author), van der Kaaij, M. (author), Visker, O.H. (author)With recent technological advances, commanders request the support of artificial intelligence (AI)-enabled systems during mission planning. Future AI systems may test a wide range of courses of action (COAs) and use a simulator to test each COA’s effectiveness in a war game. The COA’s effectiveness is however dependent on the commanders’ intent....article 2022
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Diran, D.D.D. (author), Hoekstra, M. (author), van Veenstra, A.F.E. (author)The potential of the use of data to help improve policymaking is increasingly recognized by governments, especially to address societal challenges. One of those societal challenges is the energy transition, which happens for a large part at the local government level. However, within the literature little is known about which type of...conference paper 2022
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Human-centered XAI: Developing design patterns for explanations of clinical decision support systemsSchoonderwoerd, T.A.J. (author), Jorritsma, W. (author), Neerincx, M.A. (author), van den Bosch, K. (author)Much of the research on eXplainable Artificial Intelligence (XAI) has centered on providing transparency of machine learning models. More recently, the focus on human-centered approaches to XAI has increased. Yet, there is a lack of practical methods and examples on the integration of human factors into the development processes of AI-generated...article 2021
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- van den Broeke, M. (author), Devoldere, B.P.E. (author), Creemers, S. (author), Boute, R. (author) article 2021
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Mikunda, T. (author), Brunner, L.G. (author), Skylogianni, E. (author), Garcia Moretz-Sohn Monteiro, J. (author), Rycroft, L.L. (author), Kemper, J. (author)For carbon capture and storage (CCS) to be a truly effective option within the efforts being made to mitigate climate change, it must be sustainable. An assessment is therefore required regarding how the deployment of CCS will positively contribute towards the achievement of the UN’s Sustainable Development Goals (SDGs) by 2030. This assessment...article 2021
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- Lubczynska, M.J. (author), Muetzel, R.L. (author), el Marroun, H. (author), Hoek, G. (author), Kooter, I.M. (author), Thomson, E.M. (author), Hillegers, M. (author), Vernooij, M.W. (author), White, T. (author), Tiemeier, H. (author), Guxens, M. (author) article 2021
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Abeln, E. (author)Developing the right probiotic or compound to restore gut heath can be a long, laborious and inefficient process. With i-screen Restoration (i-screen RS), TNO can accelerate pre-clinical study and selection of the right ingredients and streamline the development process.other 2021
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van Wel, L. (author), van Dommelen, P. (author), Zuurbier, M. (author), Heinen, D. (author), Odink, J. (author), Bezem, J. (author), Verkerk, P.H. (author), Pronk, A. (author), Hoek, G. (author)Air pollution, noise, and green space are important environmental exposures, having been linked to a variety of specific health outcomes. However, there are few studies addressing overall early life development. To assess their effects, associations between developmental milestones for a large population of 0–4-year old children in The...article 2021
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van Driessche, A. (author), van Stel, H.F. (author), Vink, R. (author), Staal, I.I.E. (author)Many adverse situations for parenting and healthy child development can be detected before a child’s birth. The aim of this project was to develop and test an instrument to use in prenatal home visits, to improve the identification of adverse situations and care needs during pregnancy. The preSPARK is based on a valid and reliable broad-scope...article 2021
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- Come Zebra, E.I. (author), van der Windt, H.J. (author), Nhumaio, G. (author), Faaij, A.P.C. (author) article 2021
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- Panoutsopoulos, H. (author), Brewster, C. (author), Fountas, S. (author) conference paper 2021
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Pagan, L. (author), Ederveen, R.A.M. (author), Huisman, B.W. (author), Schoones, J.W. (author), Zwittink, R.D. (author), Schuren, F.H.J. (author), Rissmann, R. (author), Piek, J.M.J. (author), van Poelgeest, M.I.E. (author)The link between cancer and the microbiome is a fast-moving field in research. There is little knowledge on the microbiome in ((pre)malignant) conditions of the vulvar skin. This systematic review aims to provide an overview of the literature regarding the microbiome composition of the healthy vulvar skin and in (pre)malignant vulvar disease....article 2021
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Deurloo, J.A. (author), Huizing, A.H.J. (author), van der Harst, S. (author), de Wilde, J. (author), van Dommelen, P. (author), Verkerk, P.H. (author)Introduction: In Dutch Youth Health Care (YHC), child development is investigated with the Dutch Development Instrument (DDI; in Dutch: Van Wiechenonderzoek). Reference values from the DDI only indicate that at least 90% of children achieve a milestone at the recommended age. The YHC-professional is not aware whether this percentage is 90% or,...article 2021
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Sentenac, M. (author), Benhammou, V. (author), Aden, U. (author), Ancel, P.Y. (author), Bakker, L.A. (author), Bakoy, H. (author), Barros, H. (author), Baumann, N. (author), Funck Bilsteen, J. (author), Boerch, K. (author), Croci, I. (author), Cuttini, M. (author), Draper, E. (author), Halvorsen, T. (author), Johnson, S. (author), Källén, K. (author), Land, T. (author), Lebeer, J. (author), Lehtonen, L. (author), Maier, R.F. (author), Marlow, N. (author), Morgan, A. (author), Ni, Y. (author), Raikkonen, K. (author), Rtimi, A. (author), Sarrechia, I. (author), Varendi, H. (author), Vollsaeter, M. (author), Wolke, D. (author), Ylijoki, M. (author), Zeitlin, J. (author)Background: Studies are sparse and inconclusive about the association between maternal education and cognitive development among children born very preterm (VPT). Although this association is well established in the general population, questions remain about its magnitude among children born VPT whose risks of medical and developmental...article 2021
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van Bilsen, J.H.M. (author), van den Brink, W. (author), van den Hoek, A.M. (author), Dulos, R. (author), Caspers, M.P.M. (author), Kleeman, R. (author), Wopereis, S. (author), Verschuren, L. (author)Metabolic disorders, such as obesity and type 2 diabetes have a large impact on global health, especially in industrialized countries. Tissue-specific chronic low-grade inflammation is a key contributor to complications in metabolic disorders. To support therapeutic approaches to these complications, it is crucial to gain a deeper understanding...article 2021
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Ennali, Y. (author), van Engers, T. (author)This paper presents an explanatory case study aimed at exploring bias leading to discriminatory decisions generated by artificial intelligence decision making systems (AI-DMS). Particularly machine learning-based AI-DMS depends on data concealing bias emerging from society. This bias could be transitioned to AI-DMS models and consequently lead...conference paper 2021
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van Vianen, A.E.M. (author), de Pater, I.E. (author), Preenen, P.T.Y. (author)The changing labour market and unpredictability of careers necessitate employees to adopt non-traditional norms of career success and assess their career in terms of employability. We propose that employees could promote their employability specifically through engagement in challenging work experiences. High quality jobs provide employees with...bookPart 2020
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van den Dries, M.A. (author), Lamballais, S. (author), El Marroun, H. (author), Pronk, A. (author), Spaan, S. (author), Ferguson, K.K. (author), Longnecker, M.P. (author), Tiemeier, H. (author), Guxens, M. (author)Background: Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine...article 2020