Searched for: subject:"Determinants"
(1 - 20 of 142)

Pages

document
de Groot, A.P. (author), Til, H.P. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Yeast grown on hydrocarbons according to the n-paraffin process of The British Petroleum Company Ltd. was fed to groups of male and female rats at dietary levels of 10, 20 and 30% for 1 yr. Two control diets were used, one being similar to the yeast diet but with soya-bean meal substituted for yeast and the other being the institute's stock diet...
article 1970
document
Polak, R.L. (author), Molenaar, P.C. (author), Medisch Biologisch Laboratorium TNO (author)
A new procedure is described for the estimation of ACh by pyrolysis-gas chromatography/mass spectrometry. ACh iodide and the iodides of ACh-d16 or propionylcholine are slowly demethylated at 250??C by pyrolysis on the tip of a glass probe after insertion into the heated entrance of a glass tube leading to a packed capillary column. The volatile...
article 1979
document
Speek, A.J. (author), van Schaik, F. (author), Schrijver, J. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A reliable high-performance liquid chromatographic (HPLC) method is developed for the analysis of FAD in whole blood of humans. The method is able to separate FAD, FMN and Rb from each other and from interfering compounds. A reliable and sensitive detection of FAD has been obtained by selecting the optimal pH of the mobile phase and optimal...
article 1982
document
van der Greef, J. (author), Leegwater, D.C. (author)
A technique for the detection of biotransformation products of xenobiotics in crude urine extracts by field desorption mass spectrometric profile analysis is described. The method comprises determination of peak profiles of a series of blank and test samples using low resolution field desorption mass spectrometry, comparison of averaged peak...
article 1983
document
Speek, A.J. (author), Odink, J. (author), Schrijver, J. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A reliable high-performance liquid chromatographic method is presented for the determination of the urinary free catecholamines noradrenaline, adrenaline and dopamine. Urine is purified on a column of immobilized boric acid. Catecholamines are separated by ion-pair reversed phase high-performance liquid chromatography and detected...
article 1983
document
Emeis, J.J. (author), Kluft, C. (author), Gaubius instituut TNO (author)
Platelet-activating factor (PAF-acether; 1-O-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) induced the release of plasminogen activator in rat, both in vivo and in perfused hind legs. The released plasminogen activator was shown by immunologic and functional criteria to be tissue-type plasminogen activator (t-PA). Release of t-PA by PAF...
article 1985
document
Speek, A.J. (author), van Agtmaal, E.J. (author), Saowakontha, S. (author), Schreurs, W.H.P. (author), van Haeringen, N.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A fast and sensitive high-performance liquid chromatographic (HPLC) method for the determination of vitamin A (all-trans retinol) in 50 ??l human tear fluid is described. After deproteinization with ethanol and extraction with n-hexane, retinol is separated from the extract on a straight-phase HPLC column and detected fluorometrically. Vitamin A...
article 1986
document
Speek, A.J. (author), Wongkham, C. (author), Limratana, N. (author), Saowakontha, S. (author), Schreurs, W.H.P. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Chemicals/CAS: n,n dimethylacetamide, 127-19-5; retinol, 68-26-8, 82445-97-4; Vitamin A, 11103-57-4
article 1986
document
Gizdulich, P. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)
Pressure-volume (p-V) relationships of a segment of the forearm circulation have been measured in nine male healthy subjects. Forearm volume was measured using electrical impedance plethysmography, arterial transmural pressure by subtracting mean arterial pressure measured contralaterally in a finger from the pressure in a cuff placed over the...
article 1988
document
Hekman, P. (author), van Rens, P. (author), Rietvel, E.C. (author), Coert, A. (author), Instituut voor Landbouwkundig Onderzoek en Biochemische Produkten TNO (author)
Chemicals/CAS: dapsone, 80-08-0
article 1989
document
Hirasing, R.A. (author), Donckerwolcke, R.A.M.G. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
Om een indruk te krijgen van de wijze van bloeddrukmeting en de criteria voor het stellen van de diagnose hypertensie in de praktijk van de jeugdgezondheidszorg werd in 1989 een schriftelijke enquête gehouden onder een aselecte steekproef van 100 schoolartsen. De respons bedroeg 62. De resultaten lieten grote verschillen in zowel methoden van...
article 1991
document
Imholz, B.P.M. (author), Wieling, W. (author), Langewouters, G.J. (author), van Montfrans, G.A. (author), TNO Biomedical Instrumentation (author)
The clinical utility for autonomic research purposes of the Finapres<sup>TM</sup>, a device for measuring finger arterial pressure continuously and noninvasively, was assessed by estimating its accuracy, precision and within-subject variability in 48 subjects, aged 18-65 years, in comparison with intraarterial brachial blood pressure. At...
article 1991
document
Jongen, M.J.M. (author), Ravensberg, J.C. (author), Engel, R. (author), Leenheers, L.H. (author), Medisch Biologisch Laboratorium TNO (author)
Health hazard surveys have been conducted on Dutch bulb farms and in greenhouses used for cultivation of carnations in order to determine occupational exposure to the fungicides zineb and maneb. Occupational exposure is estimated by determining inhalatory and dermal exposure. Inhalatory exposure is measured by personal air sampling and dermal...
article 1991
document
van Nesselrooij, J.H.J. (author), Bruijntjes, J.P. (author), Garderen van-Hoetmer, A. (author), Tillapaugh-Fay, G.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Estrogen-induced pituitary lesions in rats were studied in time-sequence experiments using magnetic resonance imaging (MRI), hormone determinations and light microscopy. The main purpose of the study was to evaluate the usefulness of MRI in comparison with conventional biochemical and histopathological methods for detecting the pituitary lesions...
article 1991
document
Kientz, C.E. (author), Prins Maurits Laboratorium TNO (author)
doctoral thesis 1992
document
van Delft, J.H.M. (author), van den Ende, A.M.C. (author), Keizer, H.J. (author), Ouwerkerk, J. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author)
An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating antitumor drug dacarbazine by i.v. administration. From four patients who received dacarbazine only, at dosages of 250, 400 or 800 mg/m2, the blood samples were collected before and several days...
article 1992
document
Slagboom, P.E. (author), Droog, S. (author), Boomsma, D.I. (author), TNO Preventie en Gezondheid (author)
Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telomeres terminate in tandemly arranged repeat arrays consisting of the (TTAGGG) motif. The length of these arrays in cells from human mitotic tissues is inversely related to the age of the donor, indicating telomere reduction with age. In addition...
article 1994
document
Fichtinger-Schepman, A.M.J. (author), van Dijk-Knijnenburg, H.C.M. (author), Dijt, F.J. (author), van der Velde-Visser, S.D. (author), Berends, F. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Cisplatin reacts with DNA by forming mainly bifunctional adducts via reactive monofunctional intermediates. When freshly platinated DNA was postincubated with thiourea (10 mM, at 23 or 37°C) for periods of up to 24 h, followed by determination of mono- and diadducts, a rapid initial decrease was seen in the fraction of diadducts, followed by a...
article 1995
document
Meulenbelt, I. (author), Droog, S. (author), Trommelen, G.J.M. (author), Boomsma, D.I. (author), Slagboom, P.E. (author), TNO Preventie en Gezondheid (author)
article 1995
document
van den Berg, K.J. (author), Lammers, J.H.C.M. (author), Hoogendijk, E.M.G. (author), Kulig, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Adult male WAG/Rij/MBL rats were dosed with lead acetate at 0, 4.0, 8.0 or 12.5 mg/kg, 5 days per week for 4 weeks. Animals were assessed prior to exposure, at the end of the 4-week exposure period and after a 2-week recovery period using a functional observational battery (FOB) and motor activity assessment. Rats were sacrificed two weeks after...
article 1996
Searched for: subject:"Determinants"
(1 - 20 of 142)

Pages