Searched for: subject:"Determinants"
(1 - 20 of 144)

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Noort, D. (author), Hulst, A.G. (author), Fidder, A. (author), van Gurp, R.A. (author), de Jong, L.P.A. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
The development of procedures for retrospective detection and quantitation of exposure to phosgene, based on adducts to hemoglobin and albumin, is described. Upon incubation of human blood with [14C]phosgene (0-750 μM), a significant part of radioactivity (0-13%) became associated with globin and albumin. Upon Pronase digestion of globin, one of...
article 2000
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Delahaij, R. (author), Theunissen, N.C.M. (author), Six, C. (author)
The purpose of this study was to investigate the underlying mechanisms that explain the influence of instructor support on attrition levels within Navy basic military training. Based on self-determination theory, we hypothesized that higher autonomy support leads to lower intent to quit, mediated by self-efficacy and training value. Results from...
article 2014
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Rosendal, H. (author), Vondeling, H. (author), de Witte, L.P. (author), Hutubessy, R.C.W. (author), van Beekum, W.T. (author), Heine, R.J. (author)
Objective. Assessing whether the initiation of insulin therapy in patients with diabetes mellitus type 2 can be delivered as effectively in a structured transmural care model as in the more usual outpatients structure. Design. Retrospective comparative cohort study. Method. In 1997 data were collected from 52 patients with diabetes mellitus type...
article 2002
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Bouman, J. (author), Ebbing, J. (author), Meekes, S. (author), Fattah, R.A. (author), Fuchs, M. (author), Gradmann, S. (author), Haagmans, R. (author), Lieb, V. (author), Schmidt, M. (author), Dettmering, D. (author), Bosch, W. (author)
The Gravity field and steady-state Ocean Circulation Explorer (GOCE) is the European Space Agency's (ESA)satellite gravity mission to determine the Earth's mean gravity field. GOCE delivers gravity gradients, anew type of satellite data. We study how these data can improve modeling of the Earth's lithosphere. We discuss the use of the original...
article 2015
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Karnaukhova, E. (author), Ophir, Y. (author), Trinh, L. (author), Dalal, N. (author), Punt, P.J. (author), Golding, B. (author), Shiloach, J. (author), TNO Kwaliteit van Leven (author)
Background: Human α1-proteinase inhibitor (α1-PI), also known as antitrypsin, is the most abundant serine protease inhibitor (serpin) in plasma. Its deficiency is associated with development of progressive, ultimately fatal emphysema. Currently in the United States, α1-PI is available for replacement therapy as an FDA licensed plasma-derived (pd...
article 2007
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Pots, A.M. (author), Gruppen, H. (author), van Diepenbeek, R. (author), van der Lee, J.J. (author), van Boekel, M.A.J.S. (author), Wijngaards, G. (author), Voragen, A.G.J. (author)
The content and biological activity of patatin and the protease inhibitors of molecular size 20-22 kDa present in whole potato tubers were investigated as a function of storage time. The amount of buffer-extractable protein decreased gradually during storage of whole potatoes of the cultivars Bintje and Desiree for 47 weeks whereas, for Elkana,...
article 1999
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Schellen, A. (author), Ooms, B. (author), van de Lagemaat, D. (author), Vreeken, R. (author), van Dongen, W.D. (author), TNO Voeding (author)
A generic method was developed for the fast determination of a wide range of drugs in serum or plasma. The methodology comprises generic solid-phase extraction, on-line coupled to gradient HPLC with tandem mass spectrometric detection (SPE-LC-MS/MS). The individual components of the SPE-LC-MS/MS system were optimized in an integrated approach to...
article 2003
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Lugovskoy, E.V. (author), Kolesnikova, I.N. (author), Gritsenko, P.G. (author), Zolotareva, E.N. (author), Gaffney, P. (author), Nieuwenhuizen, W. (author), Komisarenko, S.V. (author), TNO Preventie en Gezondheid (author)
Monoclonal antibody (mAb) III-3b binds D-dimer with Kd = 1.4 × 10-10 M without cross-reaction with fibrin(ogen). The epitope for this mAb is in Bβ134-190, presumably in Bβ155-160. The latter site is buried in the coiled coil structure of fibrin(ogen) but it is exposed as a neoantigenic determinant in D-dimer upon plasmic lysis of fibrin. mAb III...
article 2002
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Gizdulich, P. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)
Pressure-volume (p-V) relationships of a segment of the forearm circulation have been measured in nine male healthy subjects. Forearm volume was measured using electrical impedance plethysmography, arterial transmural pressure by subtracting mean arterial pressure measured contralaterally in a finger from the pressure in a cuff placed over the...
article 1988
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Siemonsma, P. (author), Dopp, C. (author), Alpay, L. (author), Tak, E. (author), van Meeteren, N. (author), Chorus, A. (author)
Purpose: Home-based rehabilitation is a promising alternative to regular center-based stroke rehabilitation. The objective of this study was to identify what is currently known about determinants that influence the implementation of home-based stroke rehabilitation (HBSR) in clinical practice. Methods: A systematic review of determinants of HBSR...
article 2014
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Wiefferink, C.H. (author), Peters, L. (author), Hoekstra, F. (author), Ten Dam, G. (author), Buijs, G.J. (author), Paulussen, T.G.W.M. (author), TNO Kwaliteit van Leven (author)
Characterizing school health promotion is its category-by-category approach, in which each separate health-related behavior is addressed independently. Such an approach creates a risk that extra-curricular activities become overloaded, and that teaching staff are distracted by continuous innovations. Within the health promotion sector there are...
article 2006
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Blankvoort, B.M.G. (author), Aarts, J.M.M.J.G. (author), Schilt, R. (author), Geerdink, P. (author), Spenkelink, B. (author), Rodenburg, R.J.T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Despite a ban by the European Union, the use of anabolic steroids and repartitioning agents in cattle is still occasionally observed. Due to continuing improvements in analytical techniques, very low detection limits for individual compounds have been achieved. In response to these developments, cocktails composed of several steroids have been...
article 2003
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Germolec, D.R. (author), Kashon, M. (author), Nyska, A. (author), Kuper, C.F. (author), Portier, C. (author), Kommineni, C. (author), Johnson, K.A. (author), Luster, M.I. (author), TNO Voeding (author)
The accuracy of extended histopathology to detect immunotoxic chemicals in female B6C3F1 mice was evaluated under the auspices of the National Toxicology Program (NTP). A workgroup was formed consisting of four pathologists who conducted extended histopathological evaluation of lymphoid tissues obtained from a subset of NTP toxicology studies,...
article 2004
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Wenczl, E. (author), van der Schans, G.P. (author), Roza, L. (author), Kolb, R.M. (author), Timmerman, A.J. (author), Smit, N.P.M. (author), Pavel, S. (author), Schothorst, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The question of whether melanins are photoprotecting and/or photosensitizing in human skin cells continues to be debated. To evaluate the role of melanin upon UVA irradiation, DNA single-strand breaks (ssb) were measured in human melanocytes differing only in the amount of pigment produced by culturing at two different concentrations, basic (0...
article 1998
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Zuang, V. (author), Alonso, M.A. (author), Botham, P.A. (author), Eskes, C. (author), Fentem, J. (author), Liebsch, M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
article 2005
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van Wechem, S.N. (author), Brug, J. (author), van Assema, P. (author), Kistemaker, C. (author), Riedstra, M. (author), Löwik, M.R.H. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
In the Netherlands, the nationwide Fat Watch campaign aiming at a reduction in fat consumption was organized from 1991 onwards. This study describes the effects of the first three consecutive campaign years on attention to fat, diet and health, attitudes, self-efficacy expectations and intentions related to dietary fat reduction, and self-rated...
article 1998
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Mol, H.G.J. (author), van Dam, R.C.J. (author), Vreeken, R.J. (author), Steijger, O.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A straightforward and efficient method was developed for the determination of intact daminozide in apples and apple leaves. After extraction with methanol and a clean-up step using a graphitized carbon cartridge, the extract was analysed by ion-trap liquid chromatography-tandem mass spectrometry (LC-MS-MS) using atmospheric pressure chemical...
article 1999
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End, C. (author), Bikker, F.J. (author), Renner, M. (author), Bergmann, G. (author), Lyer, S. (author), Blaich, S. (author), Hudler, M. (author), Helmke, B. (author), Gassler, N. (author), Autschbach, F. (author), Ligtenberg, A.J.M. (author), Benner, A. (author), Holmskov, U. (author), Schirmacher, P. (author), Nieuw Amerongen, A.V. (author), Rosenstiel, P. (author), Sina, C. (author), Franke, A. (author), Hafner, M. (author), Kioschis, P. (author), Schreiber, S. (author), Poustka, A. (author), Mollenhauer, J. (author)
Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS-induced TLR4-mediated NF-kappaB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the molecular basis of its function...
article 2009
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van den Berg, K.J. (author), Lammers, J.H.C.M. (author), Hoogendijk, E.M.G. (author), Kulig, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Adult male WAG/Rij/MBL rats were dosed with lead acetate at 0, 4.0, 8.0 or 12.5 mg/kg, 5 days per week for 4 weeks. Animals were assessed prior to exposure, at the end of the 4-week exposure period and after a 2-week recovery period using a functional observational battery (FOB) and motor activity assessment. Rats were sacrificed two weeks after...
article 1996
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Angelova, N. (author), Kong, H.-W. (author), van de Heijden, R. (author), Yang, S.-Y. (author), Choi, Y.H. (author), Kim, H.K. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author), Xu, G. (author), Verpoorte, R. (author), TNO Kwaliteit van Leven (author)
This review summarises the most recent developments in ginseng analysis, in particular the novel approaches in sample pre-treatment and the use of high-performance liquid-chromatography-mass spectrometry. The review also presents novel data on analysing ginseng extracts by nuclear magnetic resonance spectroscopy and high-resolution mass...
article 2008
Searched for: subject:"Determinants"
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