Searched for: subject:"Determinants"
(1 - 20 of 142)

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Noort, D. (author), Hulst, A.G. (author), Fidder, A. (author), van Gurp, R.A. (author), de Jong, L.P.A. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
The development of procedures for retrospective detection and quantitation of exposure to phosgene, based on adducts to hemoglobin and albumin, is described. Upon incubation of human blood with [14C]phosgene (0-750 μM), a significant part of radioactivity (0-13%) became associated with globin and albumin. Upon Pronase digestion of globin, one of...
article 2000
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Delahaij, R. (author), Theunissen, N.C.M. (author), Six, C. (author)
The purpose of this study was to investigate the underlying mechanisms that explain the influence of instructor support on attrition levels within Navy basic military training. Based on self-determination theory, we hypothesized that higher autonomy support leads to lower intent to quit, mediated by self-efficacy and training value. Results from...
article 2014
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Rosendal, H. (author), Vondeling, H. (author), de Witte, L.P. (author), Hutubessy, R.C.W. (author), van Beekum, W.T. (author), Heine, R.J. (author)
Objective. Assessing whether the initiation of insulin therapy in patients with diabetes mellitus type 2 can be delivered as effectively in a structured transmural care model as in the more usual outpatients structure. Design. Retrospective comparative cohort study. Method. In 1997 data were collected from 52 patients with diabetes mellitus type...
article 2002
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Bouman, J. (author), Ebbing, J. (author), Meekes, S. (author), Fattah, R.A. (author), Fuchs, M. (author), Gradmann, S. (author), Haagmans, R. (author), Lieb, V. (author), Schmidt, M. (author), Dettmering, D. (author), Bosch, W. (author)
The Gravity field and steady-state Ocean Circulation Explorer (GOCE) is the European Space Agency's (ESA)satellite gravity mission to determine the Earth's mean gravity field. GOCE delivers gravity gradients, anew type of satellite data. We study how these data can improve modeling of the Earth's lithosphere. We discuss the use of the original...
article 2015
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Karnaukhova, E. (author), Ophir, Y. (author), Trinh, L. (author), Dalal, N. (author), Punt, P.J. (author), Golding, B. (author), Shiloach, J. (author), TNO Kwaliteit van Leven (author)
Background: Human α1-proteinase inhibitor (α1-PI), also known as antitrypsin, is the most abundant serine protease inhibitor (serpin) in plasma. Its deficiency is associated with development of progressive, ultimately fatal emphysema. Currently in the United States, α1-PI is available for replacement therapy as an FDA licensed plasma-derived (pd...
article 2007
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Pots, A.M. (author), Gruppen, H. (author), van Diepenbeek, R. (author), van der Lee, J.J. (author), van Boekel, M.A.J.S. (author), Wijngaards, G. (author), Voragen, A.G.J. (author)
The content and biological activity of patatin and the protease inhibitors of molecular size 20-22 kDa present in whole potato tubers were investigated as a function of storage time. The amount of buffer-extractable protein decreased gradually during storage of whole potatoes of the cultivars Bintje and Desiree for 47 weeks whereas, for Elkana,...
article 1999
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Franken, R. (author), Shandilya, N. (author), Marquart, H. (author), McNally, K. (author), Fransman, W. (author)
Measured data are generally preferred to modelled estimates of exposure. Grouping and read-across is already widely used and accepted approach in toxicology, but an appropriate approach and guidance on how to use existing exposure measurement data on one substance and work situation for another substance and/or work situation is currently not...
article 2020
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Schellen, A. (author), Ooms, B. (author), van de Lagemaat, D. (author), Vreeken, R. (author), van Dongen, W.D. (author), TNO Voeding (author)
A generic method was developed for the fast determination of a wide range of drugs in serum or plasma. The methodology comprises generic solid-phase extraction, on-line coupled to gradient HPLC with tandem mass spectrometric detection (SPE-LC-MS/MS). The individual components of the SPE-LC-MS/MS system were optimized in an integrated approach to...
article 2003
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Celis-Morales, C. (author), Livingstone, K.M. (author), Woolhead, C. (author), Forster, H. (author), O’Donovan, C.B. (author), Macready, A.L. (author), Fallaize, R. (author), Marsaux, C.F.M. (author), Tsirigoti, L. (author), Efstathopoulou, E. (author), Moschonis, G. (author), Navas-Carretero, S. (author), San-Cristobal, R. (author), Kolossa, S. (author), Klein, U.L. (author), Hallmann, J. (author), Godlewska, M. (author), Surwiłło, A. (author), Drevon, C.A. (author), Bouwman, J. (author), Grimaldi, K. (author), Parnell, L.D. (author), Manios, Y. (author), Traczyk, I. (author), Gibney, E.R. (author), Brennan, L. (author), Walsh, M.C. (author), Lovegrove, J.A. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gibney, M. (author), Mathers, J.C. (author)
In e-health intervention studies, there are concerns about the reliability of internet-based, self-reported (SR) data and about the potential for identity fraud. This study introduced and tested a novel procedure for assessing the validity of internet-based, SR identity and validated anthropometric and demographic data via measurements performed...
article 2015
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Schols, M.W.A. (author), de Ruiter, C. (author), Ory, F.G. (author)
Background Public child healthcare doctors and nurses, and primary school teachers play a pivotal role in the detection and reporting of child abuse, because they encounter almost all children in the population during their daily work. However, they report relatively few cases of suspected child abuse to child protective agencies. The aim of...
article 2013
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Lugovskoy, E.V. (author), Kolesnikova, I.N. (author), Gritsenko, P.G. (author), Zolotareva, E.N. (author), Gaffney, P. (author), Nieuwenhuizen, W. (author), Komisarenko, S.V. (author), TNO Preventie en Gezondheid (author)
Monoclonal antibody (mAb) III-3b binds D-dimer with Kd = 1.4 × 10-10 M without cross-reaction with fibrin(ogen). The epitope for this mAb is in Bβ134-190, presumably in Bβ155-160. The latter site is buried in the coiled coil structure of fibrin(ogen) but it is exposed as a neoantigenic determinant in D-dimer upon plasmic lysis of fibrin. mAb III...
article 2002
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Gizdulich, P. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)
Pressure-volume (p-V) relationships of a segment of the forearm circulation have been measured in nine male healthy subjects. Forearm volume was measured using electrical impedance plethysmography, arterial transmural pressure by subtracting mean arterial pressure measured contralaterally in a finger from the pressure in a cuff placed over the...
article 1988
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Siemonsma, P. (author), Dopp, C. (author), Alpay, L. (author), Tak, E. (author), van Meeteren, N. (author), Chorus, A. (author)
Purpose: Home-based rehabilitation is a promising alternative to regular center-based stroke rehabilitation. The objective of this study was to identify what is currently known about determinants that influence the implementation of home-based stroke rehabilitation (HBSR) in clinical practice. Methods: A systematic review of determinants of HBSR...
article 2014
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Wiefferink, C.H. (author), Peters, L. (author), Hoekstra, F. (author), Ten Dam, G. (author), Buijs, G.J. (author), Paulussen, T.G.W.M. (author), TNO Kwaliteit van Leven (author)
Characterizing school health promotion is its category-by-category approach, in which each separate health-related behavior is addressed independently. Such an approach creates a risk that extra-curricular activities become overloaded, and that teaching staff are distracted by continuous innovations. Within the health promotion sector there are...
article 2006
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Chastin, S.F.M. (author), De Craemer, M. (author), Lien, N. (author), Bernaards, C. (author), Buck, C. (author), Oppert, J.M. (author), Nazare, J.A. (author), Lakerveld, J. (author), O'Donoghue, G. (author), Holdsworth, M. (author), Owen, N. (author), Brug, J. (author), Cardon, G. (author)
Background Ecological models are currently the most used approaches to classify and conceptualise determinants of sedentary behaviour, but these approaches are limited in their ability to capture the complexity of and interplay between determinants. The aim of the project described here was to develop a transdisciplinary dynamic framework,...
article 2016
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Blankvoort, B.M.G. (author), Aarts, J.M.M.J.G. (author), Schilt, R. (author), Geerdink, P. (author), Spenkelink, B. (author), Rodenburg, R.J.T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Despite a ban by the European Union, the use of anabolic steroids and repartitioning agents in cattle is still occasionally observed. Due to continuing improvements in analytical techniques, very low detection limits for individual compounds have been achieved. In response to these developments, cocktails composed of several steroids have been...
article 2003
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Fleuren, M.A.H. (author), Vrijkotte, S. (author), Jans, M.P. (author), Pin, R. (author), van Hespen, A. (author), van Meeteren, N.L.U. (author), Siemonsma, P.C. (author)
Background: The Functional Task Exercise programme is an evidence-based exercise programme for elderly people living at home. It enhances physical capacity with sustainable effects. FTE is provided by physiotherapists and remedial therapists. Although the intervention was found to be effective in a Randomised Controlled Trial, we may not assume...
article 2012
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Germolec, D.R. (author), Kashon, M. (author), Nyska, A. (author), Kuper, C.F. (author), Portier, C. (author), Kommineni, C. (author), Johnson, K.A. (author), Luster, M.I. (author), TNO Voeding (author)
The accuracy of extended histopathology to detect immunotoxic chemicals in female B6C3F1 mice was evaluated under the auspices of the National Toxicology Program (NTP). A workgroup was formed consisting of four pathologists who conducted extended histopathological evaluation of lymphoid tissues obtained from a subset of NTP toxicology studies,...
article 2004
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Wenczl, E. (author), van der Schans, G.P. (author), Roza, L. (author), Kolb, R.M. (author), Timmerman, A.J. (author), Smit, N.P.M. (author), Pavel, S. (author), Schothorst, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The question of whether melanins are photoprotecting and/or photosensitizing in human skin cells continues to be debated. To evaluate the role of melanin upon UVA irradiation, DNA single-strand breaks (ssb) were measured in human melanocytes differing only in the amount of pigment produced by culturing at two different concentrations, basic (0...
article 1998
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Zuang, V. (author), Alonso, M.A. (author), Botham, P.A. (author), Eskes, C. (author), Fentem, J. (author), Liebsch, M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
article 2005
Searched for: subject:"Determinants"
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