Searched for: subject:"Determinants"
(1 - 15 of 15)
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Witkamp, R.F. (author), TNO Kwaliteit van Leven (author)
A sensitive and specific LC-MS/MS method for the quantification of the endocannabinoids and related structures anandamide, 2-arachidonoyl glycerol, 2-arachidonyl glycerol ether, O-arachidonoyl ethanolamide, dihomo-γ-linolenoyl ethanolamide, docosatetraenoyl ethanolamide, N-arachidonoyl dopamine, N-arachidonyl glycine, N-oleoyl dopamine, oleoyl...
article 2009
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de Boer, W.E.L. (author), Donceel, P. (author), Brage, S. (author), Rus, M. (author), Willems, J.H.B.M. (author), TNO Kwaliteit van Leven (author)
Background. Decisions on disability pensions are based, among others, on medical reports. The way these medical assessments are performed is largely unclear. The aim of the study was to determine which grounds are used by social insurance physicians (SIPs) in these assessments and to determine if the identification of these grounds can help...
article 2008
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Karnaukhova, E. (author), Ophir, Y. (author), Trinh, L. (author), Dalal, N. (author), Punt, P.J. (author), Golding, B. (author), Shiloach, J. (author), TNO Kwaliteit van Leven (author)
Background: Human α1-proteinase inhibitor (α1-PI), also known as antitrypsin, is the most abundant serine protease inhibitor (serpin) in plasma. Its deficiency is associated with development of progressive, ultimately fatal emphysema. Currently in the United States, α1-PI is available for replacement therapy as an FDA licensed plasma-derived (pd...
article 2007
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Nielen, M.W.F. (author), van Engelen, M.C. (author), Zuiderent, R. (author), Ramaker, R. (author), TNO Kwaliteit van Leven (author)
An emerging trend is recognised in hormone and veterinary drug residue analysis from liquid chromatography tandem mass spectrometry (LC/MS/MS) based screening and confirmation towards accurate mass alternatives such as LC coupled with time-of-flight (TOF), Fourier transform ion cyclotron resonance (FTICR) or Fourier transform orbitrap (FT...
article 2007
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Freidig, A.P. (author), Dekkers, S. (author), Verwei, M. (author), Zvinavashe, E. (author), Bessems, J.G.M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
Future EU legislations enforce a fast hazard and risk assessment of thousands of existing chemicals. If conducted by means of present data requirements, this assessment will use a huge number of test animals and will be neither cost nor time effective. The purpose of the current research was to develop methods to increase the acceptability of in...
article 2007
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Visser, A. (author), Broers, H.P. (author), van der Grift, B. (author), Bierkens, M.F.P. (author), TNO Bouw en Ondergrond (author)
Recent EU legislation is directed to reverse the upward trends in the concentrations of agricultural pollutants in groundwater. However, uncertainty of the groundwater travel time towards the screens of the groundwater quality monitoring networks complicates the demonstration of trend reversal. We investigated whether trend reversal can be...
article 2007
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Bobeldijk, I. (author), Boonzaaijer, G. (author), Spies-Faber, E.J. (author), Vaes, W.H.J. (author), TNO Kwaliteit van Leven (author)
Reversed-phase liquid chromatography and detection with atmospheric pressure chemical ionisation tandem mass spectrometry was used for the determination of kava extracts in herbal mixtures. One percent of kava extract can be detected, corresponding to approximately 0.05-0.2 mg/g of the individual kava lactones kavain, dihydrokavain, yangonin,...
article 2005
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Germolec, D.R. (author), Kashon, M. (author), Nyska, A. (author), Kuper, C.F. (author), Portier, C. (author), Kommineni, C. (author), Johnson, K.A. (author), Luster, M.I. (author), TNO Voeding (author)
The accuracy of extended histopathology to detect immunotoxic chemicals in female B6C3F1 mice was evaluated under the auspices of the National Toxicology Program (NTP). A workgroup was formed consisting of four pathologists who conducted extended histopathological evaluation of lymphoid tissues obtained from a subset of NTP toxicology studies,...
article 2004
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de Ligt, R.A.F. (author), van der Klein, P.A.M. (author), von Frijtag Drabbe Künzel, J.K. (author), Lorenzen, A. (author), El Maate, F.A. (author), Fujikawa, S. (author), van Westhoven, R. (author), van den Hoven, T. (author), Brussee, J. (author), Ijzerman, A.P. (author), TNO Voeding (author)
Novel 3,8- and 8,9-disubstituted N6-cyclopentyladenine derivatives were synthesised in moderate overall yield from 6-chloropurine. The derivatives were made in an attempt to find a new neutral antagonist with high affinity for adenosine A1 receptors. N6-Cyclopentyl-9- methyladenine (N-0840) was used as a lead compound. Binding affinities of the...
article 2004
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Majhenič, A.Č. (author), Venema, K. (author), Allison, G.E. (author), Matijašić, B.B. (author), Rogelj, I. (author), Klaenhammer, T.R. (author), TNO Voeding (author)
Lactobacillus gasseri LF221, an isolate from the feces of a child, produces two bacteriocins. Standard procedures for molecular techniques were used to locate, clone and sequence the fragments of LF221 chromosomal DNA carrying the acidocin LF221 A and B structural genes, respectively. Sequencing analysis revealed the gene of acidocin LF221 A to...
article 2004
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Schellen, A. (author), Ooms, B. (author), van de Lagemaat, D. (author), Vreeken, R. (author), van Dongen, W.D. (author), TNO Voeding (author)
A generic method was developed for the fast determination of a wide range of drugs in serum or plasma. The methodology comprises generic solid-phase extraction, on-line coupled to gradient HPLC with tandem mass spectrometric detection (SPE-LC-MS/MS). The individual components of the SPE-LC-MS/MS system were optimized in an integrated approach to...
article 2003
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Broekmans, W.M.R. (author), Vink, A.A. (author), Boelsma, E. (author), Klöpping-Ketelaars, W.A.A. (author), Tijburg, L.B.M. (author), van 't Veer, P. (author), van Poppel, G. (author), Kardinaal, A.F.M. (author), TNO Voeding (author)
Background: Acute effects of UV irradiation include UV-induced erythema. Sunlight plays an important role in the development of skin cancer. Several predictive factors of UV-induced erythema could also be predictive for skin cancer. Objective: Our objective was to quantitatively assess phenotypical and nutritional determinants of sensitivity to...
article 2003
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Lugovskoy, E.V. (author), Kolesnikova, I.N. (author), Gritsenko, P.G. (author), Zolotareva, E.N. (author), Gaffney, P. (author), Nieuwenhuizen, W. (author), Komisarenko, S.V. (author), TNO Preventie en Gezondheid (author)
Monoclonal antibody (mAb) III-3b binds D-dimer with Kd = 1.4 × 10-10 M without cross-reaction with fibrin(ogen). The epitope for this mAb is in Bβ134-190, presumably in Bβ155-160. The latter site is buried in the coiled coil structure of fibrin(ogen) but it is exposed as a neoantigenic determinant in D-dimer upon plasmic lysis of fibrin. mAb III...
article 2002
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de Maat, M.P.M. (author), Green, F. (author), de Knijff, P. (author), Jespersen, J. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Increased plasma factor VII coagulant activity (FVII:C) has been associated with the risk of ischemic heart disease (IHD). Differences in plasma FVII:C among individuals are associated with three common polymorphisms in the FVII gene. Therefore, we investigated FVII polymorphisms in four populations that differ in their risk of developing...
article 1997
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van Nesselrooij, J.H.J. (author), Bruijntjes, J.P. (author), Garderen van-Hoetmer, A. (author), Tillapaugh-Fay, G.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Estrogen-induced pituitary lesions in rats were studied in time-sequence experiments using magnetic resonance imaging (MRI), hormone determinations and light microscopy. The main purpose of the study was to evaluate the usefulness of MRI in comparison with conventional biochemical and histopathological methods for detecting the pituitary lesions...
article 1991
Searched for: subject:"Determinants"
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