Searched for: subject:"Determinants"
(1 - 20 of 20)
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Speek, A.J. (author), van Schaik, F. (author), Schrijver, J. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A reliable high-performance liquid chromatographic (HPLC) method is developed for the analysis of FAD in whole blood of humans. The method is able to separate FAD, FMN and Rb from each other and from interfering compounds. A reliable and sensitive detection of FAD has been obtained by selecting the optimal pH of the mobile phase and optimal...
article 1982
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van der Greef, J. (author), Leegwater, D.C. (author)
A technique for the detection of biotransformation products of xenobiotics in crude urine extracts by field desorption mass spectrometric profile analysis is described. The method comprises determination of peak profiles of a series of blank and test samples using low resolution field desorption mass spectrometry, comparison of averaged peak...
article 1983
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Hekman, P. (author), van Rens, P. (author), Rietvel, E.C. (author), Coert, A. (author), Instituut voor Landbouwkundig Onderzoek en Biochemische Produkten TNO (author)
Chemicals/CAS: dapsone, 80-08-0
article 1989
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Fichtinger-Schepman, A.M.J. (author), van Dijk-Knijnenburg, H.C.M. (author), Dijt, F.J. (author), van der Velde-Visser, S.D. (author), Berends, F. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Cisplatin reacts with DNA by forming mainly bifunctional adducts via reactive monofunctional intermediates. When freshly platinated DNA was postincubated with thiourea (10 mM, at 23 or 37°C) for periods of up to 24 h, followed by determination of mono- and diadducts, a rapid initial decrease was seen in the fraction of diadducts, followed by a...
article 1995
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van den Berg, K.J. (author), Lammers, J.H.C.M. (author), Hoogendijk, E.M.G. (author), Kulig, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Adult male WAG/Rij/MBL rats were dosed with lead acetate at 0, 4.0, 8.0 or 12.5 mg/kg, 5 days per week for 4 weeks. Animals were assessed prior to exposure, at the end of the 4-week exposure period and after a 2-week recovery period using a functional observational battery (FOB) and motor activity assessment. Rats were sacrificed two weeks after...
article 1996
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Wenczl, E. (author), van der Schans, G.P. (author), Roza, L. (author), Kolb, R.M. (author), Timmerman, A.J. (author), Smit, N.P.M. (author), Pavel, S. (author), Schothorst, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The question of whether melanins are photoprotecting and/or photosensitizing in human skin cells continues to be debated. To evaluate the role of melanin upon UVA irradiation, DNA single-strand breaks (ssb) were measured in human melanocytes differing only in the amount of pigment produced by culturing at two different concentrations, basic (0...
article 1998
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van Wechem, S.N. (author), Brug, J. (author), van Assema, P. (author), Kistemaker, C. (author), Riedstra, M. (author), Löwik, M.R.H. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
In the Netherlands, the nationwide Fat Watch campaign aiming at a reduction in fat consumption was organized from 1991 onwards. This study describes the effects of the first three consecutive campaign years on attention to fat, diet and health, attitudes, self-efficacy expectations and intentions related to dietary fat reduction, and self-rated...
article 1998
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van Puymbroeck, M. (author), Kuilman, M.E.M. (author), Maas, R.F.M. (author), Witkamp, R.F. (author), Leyssens, T. (author), van der Zande, D.J.M. (author), Gelan, J. (author), Raus, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Current veterinary residue analysis mainly focuses on the monitoring of residues of the administered parent compound. However, it is possible that larger amounts of metabolites are excreted and that they can have a prolonged excretion period. In order to unravel specific metabolic steps and to identify possible biological markers, two in vitro...
article 1998
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Elliott, C.T. (author), Baxter, G.A. (author), Hewitt, S.A. (author), Arts, C.J.M. (author), van Baak, M. (author), Hellenäs, K.-E. (author), Johannson, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The drug salbutamol (SBL) is a β-agonist that may be used illegally as an animal growth promoter. SBL is also a good example of a drug which is excreted in the form of glucuronides and sulfates. Such metabolites cause complexities in analysing for the presence of drug residues. In the majority of cases a process of deconjugation and sample clean...
article 1998
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de Jong, E.C. (author), van Zijverden, M. (author), Spanhaak, S. (author), Koppelman, S.J. (author), Pellegrom, H. (author), Penninks, A.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Peanuts are a major cause of food allergies both in children as in adults which can induce an anaphylactic shock. The identification and characterization of peanut allergens could lead to more insight into the mechanism and contribute to the improvement of diagnostic tests and treatment for peanut allergy. Objectives: In the present...
article 1998
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Mol, H.G.J. (author), van Dam, R.C.J. (author), Vreeken, R.J. (author), Steijger, O.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A straightforward and efficient method was developed for the determination of intact daminozide in apples and apple leaves. After extraction with methanol and a clean-up step using a graphitized carbon cartridge, the extract was analysed by ion-trap liquid chromatography-tandem mass spectrometry (LC-MS-MS) using atmospheric pressure chemical...
article 1999
document
Knebel, N.G. (author), Grieb, S. (author), Winkler, M. (author), Locher, M. (author), van der Vlis, E. (author), Verheij, E.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
An HPLC assay with tandem mass spectrometric detection in the positive-ion Turbo-Ion-Spray((TM)) (TISP) mode for the fast and sensitive determination of perifosine ((I), D-21266) in human plasma was developed, utilising the structural analogue, miltefosine ((II), D-18506), as internal standard. Automated solid-phase extraction of diluted plasma...
article 1999
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Schenk, H. (author), Driessen, R.A.J. (author), de Gelder, R. (author), Goubitz, K. (author), Nieboer, H. (author), Brüggemann-Rotgans, I.E.M. (author), Diepenhorst, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Potato crops can be severely damaged by potato cyst nematodes Globodera rostochiensis and Globodera pallida, nematodes highly specific to potatoes and some other Solanaceae. Hatching of juveniles is controlled by agents excreted by the roots of some Solanaceae species. Over seventy years much effort has been expended by many groups to isolate...
article 1999
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Brunt, K. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
This paper describes the collaborative study for establishing the repeatability and reproducibility of a recently developed new enzymatic starch determination. The ring test was in accordance to the ISO 5725 requirements for interlaboratory studies. The interlaboratory test resulted in a good relative repeatability of 1-2% and a relative...
article 2000
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Kralj, S. (author), Stripling, E. (author), Sanders, P. (author), van Geel-Schutten, G.H. (author), Dijkhuizen, L. (author), TNO Kwaliteit van Leven (author)
Lactobacillus reuteri strain ATCC 55730 (LB BIO) was isolated as a pure culture from a Reuteri tablet purchased from the BioGaia company. This probiotic strain produces a soluble glucan (reuteran), in which the majority of the linkages are of the α-(1→4) glucosidic type (∼70%). This reuteran also contains α-(1→6)-linked glucosyl units and 4,6...
article 2005
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Wiefferink, C.H. (author), Peters, L. (author), Hoekstra, F. (author), Ten Dam, G. (author), Buijs, G.J. (author), Paulussen, T.G.W.M. (author), TNO Kwaliteit van Leven (author)
Characterizing school health promotion is its category-by-category approach, in which each separate health-related behavior is addressed independently. Such an approach creates a risk that extra-curricular activities become overloaded, and that teaching staff are distracted by continuous innovations. Within the health promotion sector there are...
article 2006
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Primo-Martín, C. (author), de Beukelaer, H. (author), Hamer, R.J. (author), van Vliet, T. (author), TNO Kwaliteit van Leven (author)
The effect of air and vacuum cooling on the fracture behaviour and accompanying sound emission, moisture content and crispness of bread crust were investigated. Vacuum cooling resulted in rapid evaporative cooling of products that contained high moisture content. Fracture experiments showed a clear dependence of fracture properties on the way...
article 2008
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Marquart, H. (author), Schneider, T. (author), Goede, H. (author), Tischer, M. (author), Schinkel, J. (author), Warren, N. (author), Fransman, W. (author), Spaan, S. (author), van Tongeren, M. (author), Kromhout, H. (author), Tielemans, E. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
There is a large variety of activities in workplaces that can lead to emission of substances. Coding systems based on determinants of emission have so far not been developed. In this paper, a system of Activity Classes and Activity Subclasses is proposed for categorizing activities involving chemical use. Activity Classes share their so-called ...
article 2011
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Kocken, P.L. (author), Scholten, A.M. (author), Westhoff, E. (author), Kok, B.P.H. (author), Taal, E.M. (author), Goldbohm, R.A. (author)
The effectiveness of the “Extra Fit!” (EF!) education program in promoting healthy diet and physical activity to prevent and reduce overweightness among primary school children aged 9 to 11 was evaluated. A randomized controlled design was carried out in 45 primary schools (n = 1112) in the Netherlands, 23 intervention and 22 control schools....
article 2016
document
Bekker, C. (author), Fransman, W. (author), Boessen, R. (author), Oerlemans, A. (author), Ottenbros, I.B. (author), Vermeulen, R. (author)
Background: Nano-specific inhalation exposure models could potentially be effective tools to assess and control worker exposure to nano-objects, and their aggregates and agglomerates (NOAA). However, due to the lack of reliable and consistent collected NOAA exposure data, the scientific basis for validation of the existing NOAA exposure models...
article 2017
Searched for: subject:"Determinants"
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