Searched for: subject:"Determinants"
(1 - 8 of 8)
document
Mol, H.G.J. (author), van Dam, R.C.J. (author), Vreeken, R.J. (author), Steijger, O.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A straightforward and efficient method was developed for the determination of intact daminozide in apples and apple leaves. After extraction with methanol and a clean-up step using a graphitized carbon cartridge, the extract was analysed by ion-trap liquid chromatography-tandem mass spectrometry (LC-MS-MS) using atmospheric pressure chemical...
article 1999
document
Knebel, N.G. (author), Grieb, S. (author), Winkler, M. (author), Locher, M. (author), van der Vlis, E. (author), Verheij, E.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
An HPLC assay with tandem mass spectrometric detection in the positive-ion Turbo-Ion-Spray((TM)) (TISP) mode for the fast and sensitive determination of perifosine ((I), D-21266) in human plasma was developed, utilising the structural analogue, miltefosine ((II), D-18506), as internal standard. Automated solid-phase extraction of diluted plasma...
article 1999
document
van Puymbroeck, M. (author), Kuilman, M.E.M. (author), Maas, R.F.M. (author), Witkamp, R.F. (author), Leyssens, T. (author), van der Zande, D.J.M. (author), Gelan, J. (author), Raus, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Current veterinary residue analysis mainly focuses on the monitoring of residues of the administered parent compound. However, it is possible that larger amounts of metabolites are excreted and that they can have a prolonged excretion period. In order to unravel specific metabolic steps and to identify possible biological markers, two in vitro...
article 1998
document
Elliott, C.T. (author), Baxter, G.A. (author), Hewitt, S.A. (author), Arts, C.J.M. (author), van Baak, M. (author), Hellenäs, K.-E. (author), Johannson, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The drug salbutamol (SBL) is a β-agonist that may be used illegally as an animal growth promoter. SBL is also a good example of a drug which is excreted in the form of glucuronides and sulfates. Such metabolites cause complexities in analysing for the presence of drug residues. In the majority of cases a process of deconjugation and sample clean...
article 1998
document
Fichtinger-Schepman, A.M.J. (author), van Dijk-Knijnenburg, H.C.M. (author), Dijt, F.J. (author), van der Velde-Visser, S.D. (author), Berends, F. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Cisplatin reacts with DNA by forming mainly bifunctional adducts via reactive monofunctional intermediates. When freshly platinated DNA was postincubated with thiourea (10 mM, at 23 or 37°C) for periods of up to 24 h, followed by determination of mono- and diadducts, a rapid initial decrease was seen in the fraction of diadducts, followed by a...
article 1995
document
Hekman, P. (author), van Rens, P. (author), Rietvel, E.C. (author), Coert, A. (author), Instituut voor Landbouwkundig Onderzoek en Biochemische Produkten TNO (author)
Chemicals/CAS: dapsone, 80-08-0
article 1989
document
van der Greef, J. (author), Leegwater, D.C. (author)
A technique for the detection of biotransformation products of xenobiotics in crude urine extracts by field desorption mass spectrometric profile analysis is described. The method comprises determination of peak profiles of a series of blank and test samples using low resolution field desorption mass spectrometry, comparison of averaged peak...
article 1983
document
Speek, A.J. (author), van Schaik, F. (author), Schrijver, J. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A reliable high-performance liquid chromatographic (HPLC) method is developed for the analysis of FAD in whole blood of humans. The method is able to separate FAD, FMN and Rb from each other and from interfering compounds. A reliable and sensitive detection of FAD has been obtained by selecting the optimal pH of the mobile phase and optimal...
article 1982
Searched for: subject:"Determinants"
(1 - 8 of 8)