Searched for: subject:"Determinants"
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van den Berg, K.J. (author), Lammers, J.H.C.M. (author), Hoogendijk, E.M.G. (author), Kulig, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Adult male WAG/Rij/MBL rats were dosed with lead acetate at 0, 4.0, 8.0 or 12.5 mg/kg, 5 days per week for 4 weeks. Animals were assessed prior to exposure, at the end of the 4-week exposure period and after a 2-week recovery period using a functional observational battery (FOB) and motor activity assessment. Rats were sacrificed two weeks after...
article 1996
Fichtinger-Schepman, A.M.J. (author), van Dijk-Knijnenburg, H.C.M. (author), Dijt, F.J. (author), van der Velde-Visser, S.D. (author), Berends, F. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Cisplatin reacts with DNA by forming mainly bifunctional adducts via reactive monofunctional intermediates. When freshly platinated DNA was postincubated with thiourea (10 mM, at 23 or 37°C) for periods of up to 24 h, followed by determination of mono- and diadducts, a rapid initial decrease was seen in the fraction of diadducts, followed by a...
article 1995