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van Delft, J.H.M. (author), van den Ende, A.M.C. (author), Keizer, H.J. (author), Ouwerkerk, J. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author)An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating antitumor drug dacarbazine by i.v. administration. From four patients who received dacarbazine only, at dosages of 250, 400 or 800 mg/m2, the blood samples were collected before and several days...article 1992
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Gaubius Instituut TNO (author), Kluft, C. (author)Chemicals/CAS: Biological Markers; Plasminogen Activator Inhibitor 1; Tissue Plasminogen Activator, EC 3.4.21.68.article 1992
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Hirasing, R.A. (author), Donckerwolcke, R.A.M.G. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Om een indruk te krijgen van de wijze van bloeddrukmeting en de criteria voor het stellen van de diagnose hypertensie in de praktijk van de jeugdgezondheidszorg werd in 1989 een schriftelijke enquête gehouden onder een aselecte steekproef van 100 schoolartsen. De respons bedroeg 62. De resultaten lieten grote verschillen in zowel methoden van...article 1991
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Imholz, B.P.M. (author), Wieling, W. (author), Langewouters, G.J. (author), van Montfrans, G.A. (author), TNO Biomedical Instrumentation (author)The clinical utility for autonomic research purposes of the Finapres<sup>TM</sup>, a device for measuring finger arterial pressure continuously and noninvasively, was assessed by estimating its accuracy, precision and within-subject variability in 48 subjects, aged 18-65 years, in comparison with intraarterial brachial blood pressure. At...article 1991
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Jongen, M.J.M. (author), Ravensberg, J.C. (author), Engel, R. (author), Leenheers, L.H. (author), Medisch Biologisch Laboratorium TNO (author)Health hazard surveys have been conducted on Dutch bulb farms and in greenhouses used for cultivation of carnations in order to determine occupational exposure to the fungicides zineb and maneb. Occupational exposure is estimated by determining inhalatory and dermal exposure. Inhalatory exposure is measured by personal air sampling and dermal...article 1991
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van Nesselrooij, J.H.J. (author), Bruijntjes, J.P. (author), Garderen van-Hoetmer, A. (author), Tillapaugh-Fay, G.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Estrogen-induced pituitary lesions in rats were studied in time-sequence experiments using magnetic resonance imaging (MRI), hormone determinations and light microscopy. The main purpose of the study was to evaluate the usefulness of MRI in comparison with conventional biochemical and histopathological methods for detecting the pituitary lesions...article 1991
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Hekman, P. (author), van Rens, P. (author), Rietvel, E.C. (author), Coert, A. (author), Instituut voor Landbouwkundig Onderzoek en Biochemische Produkten TNO (author)Chemicals/CAS: dapsone, 80-08-0article 1989
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Gizdulich, P. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)Pressure-volume (p-V) relationships of a segment of the forearm circulation have been measured in nine male healthy subjects. Forearm volume was measured using electrical impedance plethysmography, arterial transmural pressure by subtracting mean arterial pressure measured contralaterally in a finger from the pressure in a cuff placed over the...article 1988
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Speek, A.J. (author), van Agtmaal, E.J. (author), Saowakontha, S. (author), Schreurs, W.H.P. (author), van Haeringen, N.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A fast and sensitive high-performance liquid chromatographic (HPLC) method for the determination of vitamin A (all-trans retinol) in 50 ??l human tear fluid is described. After deproteinization with ethanol and extraction with n-hexane, retinol is separated from the extract on a straight-phase HPLC column and detected fluorometrically. Vitamin A...article 1986
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Speek, A.J. (author), Wongkham, C. (author), Limratana, N. (author), Saowakontha, S. (author), Schreurs, W.H.P. (author), Instituut CIVO-Toxicologie en voeding TNO (author)Chemicals/CAS: n,n dimethylacetamide, 127-19-5; retinol, 68-26-8, 82445-97-4; Vitamin A, 11103-57-4article 1986
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Emeis, J.J. (author), Kluft, C. (author), Gaubius instituut TNO (author)Platelet-activating factor (PAF-acether; 1-O-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) induced the release of plasminogen activator in rat, both in vivo and in perfused hind legs. The released plasminogen activator was shown by immunologic and functional criteria to be tissue-type plasminogen activator (t-PA). Release of t-PA by PAF...article 1985
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Centraal Instituut voor Voedingsonderzoek TNO (author), van der Greef, J. (author), Tas, A.C. (author), Rijk, M.A.H. (author), ten Noever de Brauw, M.C. (author)Progesterone can be determined rapidly and accurately with the method presented, using isotope dilution LC-MS with a moving-belt interface. Deactivation is very useful in that it minimizes belt memory effects and optimizes belt desorption characteristics. Since the moving-belt properties were found to change during time with respect to the...article 1985
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Centraal Instituut voor Voedingsonderzoek TNO (author), Speek, A.J. (author), Schrijver, J. (author), Schreurs, W.H.P. (author)Chemicals/CAS: menadione sodium bisulfite, 130-37-0; menadione, 58-27-5; 2-methyl-1,4-dihydronaphthalene, 2717-43-3; Naphthalenes; Vitamin K 3, 58-27-5; Vitamin K, 12001-79-5.article 1984
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van der Greef, J. (author), Leegwater, D.C. (author)A technique for the detection of biotransformation products of xenobiotics in crude urine extracts by field desorption mass spectrometric profile analysis is described. The method comprises determination of peak profiles of a series of blank and test samples using low resolution field desorption mass spectrometry, comparison of averaged peak...article 1983
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Speek, A.J. (author), Odink, J. (author), Schrijver, J. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A reliable high-performance liquid chromatographic method is presented for the determination of the urinary free catecholamines noradrenaline, adrenaline and dopamine. Urine is purified on a column of immobilized boric acid. Catecholamines are separated by ion-pair reversed phase high-performance liquid chromatography and detected...article 1983
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Speek, A.J. (author), van Schaik, F. (author), Schrijver, J. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A reliable high-performance liquid chromatographic (HPLC) method is developed for the analysis of FAD in whole blood of humans. The method is able to separate FAD, FMN and Rb from each other and from interfering compounds. A reliable and sensitive detection of FAD has been obtained by selecting the optimal pH of the mobile phase and optimal...article 1982
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Centraal Instituut voor Voedingsonderzoek TNO (author), Schrijver, J. (author), Speek, A.J. (author), Klosse, J.A. (author), van Rijn, H.J.M. (author), Schreurs, W.H.P. (author)A sensitive and reliable method for the determination of total thiamine (vitamin B1) in whole blood has been developed which is suited for routine analysis. After extraction, and enzymatic hydrolysis of thiamine phosphate esters, thiamine is separated from interfering compounds by a fully automated high-performance liquid chromatographic (HPLC)...article 1982
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Polak, R.L. (author), Molenaar, P.C. (author), Medisch Biologisch Laboratorium TNO (author)A new procedure is described for the estimation of ACh by pyrolysis-gas chromatography/mass spectrometry. ACh iodide and the iodides of ACh-d16 or propionylcholine are slowly demethylated at 250??C by pyrolysis on the tip of a glass probe after insertion into the heated entrance of a glass tube leading to a packed capillary column. The volatile...article 1979
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Centraal Instituut voor Voedingsonderzoek TNO (author), van Essen, M.J. (author), Heynen, J.A.C. (author), van der Veen, A.H. (author), Vonkeman, G.H. (author)A portable gibbsite analyzer suited for field operation and intended for rapid determination of available alumina is described. The available alumina content is calculated from the relative weight loss caused by the dehydration of gibbsite. More than 100 samples of gibbsite-containing bauxites of different origin, were analyzed with this...article 1971
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de Groot, A.P. (author), Til, H.P. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Yeast grown on hydrocarbons according to the n-paraffin process of The British Petroleum Company Ltd. was fed to groups of male and female rats at dietary levels of 10, 20 and 30% for 1 yr. Two control diets were used, one being similar to the yeast diet but with soya-bean meal substituted for yeast and the other being the institute's stock diet...article 1970