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Goede, H.A. (author), Tijssen, S.C.H.A. (author), Schipper, H.J. (author), Warren, N. (author), Oppl, R. (author), Kalberlah, F. (author), van Hemmen, J.J. (author), TNO Voeding (author)This paper describes how default dermal exposure values can be adjusted with modifier values for specific work situations. The work presented here is supplementary to a toolkit developed for the EU RISKOFDERM project. This toolkit is intended for the assessment and management of dermal risks in small and medium sized enterprises. Potential...article 2003
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Marquart, J. (author), Brouwer, D.H. (author), Gijsbers, J.H.J. (author), Links, I.H.M. (author), Warren, N. (author), van Hemmen, J.J. (author), TNO Voeding (author)Risk assessment of chemicals requires assessment of the exposure levels of workers. In the absence of adequate specific measured data, models are often used to estimate exposure levels. For dermal exposure only a few models exist, which are not validated externally. In the scope of a large European research programme, an analysis of potential...article 2003
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Prins Maurits Laboratorium TNO (author), Broekhuijsen, M.P. (author), Larsson, P. (author), Johansson, A. (author), Byström, M. (author), Eriksson, U. (author), Larsson, E. (author), Prior, R.G. (author), Sjöstedt, A. (author), Titball, R.W. (author), Forsman, M. (author)Francisella tularensis is a potent pathogen and a possible bioterrorism agent. Little is known, however, to explain the molecular basis for its virulence and the distinct differences in virulence found between the four recognized subspecies, F. tularensis subsp. tularensis, F. tularensis subsp. mediasiatica, F. tularensis subsp. holarctica, and...article 2003
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Rosendal, H. (author), Vondeling, H. (author), de Witte, L.P. (author), Hutubessy, R.C.W. (author), van Beekum, W.T. (author), Heine, R.J. (author)Objective. Assessing whether the initiation of insulin therapy in patients with diabetes mellitus type 2 can be delivered as effectively in a structured transmural care model as in the more usual outpatients structure. Design. Retrospective comparative cohort study. Method. In 1997 data were collected from 52 patients with diabetes mellitus type...article 2002
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Lugovskoy, E.V. (author), Kolesnikova, I.N. (author), Gritsenko, P.G. (author), Zolotareva, E.N. (author), Gaffney, P. (author), Nieuwenhuizen, W. (author), Komisarenko, S.V. (author), TNO Preventie en Gezondheid (author)Monoclonal antibody (mAb) III-3b binds D-dimer with Kd = 1.4 × 10-10 M without cross-reaction with fibrin(ogen). The epitope for this mAb is in Bβ134-190, presumably in Bβ155-160. The latter site is buried in the coiled coil structure of fibrin(ogen) but it is exposed as a neoantigenic determinant in D-dimer upon plasmic lysis of fibrin. mAb III...article 2002
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TNO Kwaliteit van Leven (author), Hehenkamp, W.J.K. (author), Rang, S. (author), van Goudoever, J. (author), Bos, W.J.W. (author), Wolf, H. (author), van der Post, J.A.M. (author)Background: Continuous beat-to-beat noninvasive blood pressure (BP) measurement is possible with Portapres®. It constructs finger arterial waveforms beat-to-beat. Dedicated software is used to analyze the arterial waveforms. A new technique has been developed to reconstruct brachial intraarterial pressure that uses return to flow (RTF). This...article 2002
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TNO Preventie en Gezondheid (author), Tolboom, T.C.A. (author), Pieterman, E. (author), van der Laan, W.H. (author), Toes, R.E.M. (author), Huidekoper, A.L. (author), Nelissen, R.G.H.H. (author), Breedveld, F.C. (author), Huizinga, T.W.J. (author)Background: Matrix metalloproteinases (MMPs) have a pivotal role in the destruction of cartilage in rheumatoid arthritis (RA), which is mediated by the fibroblast-like synoviocytes (FLS). Objective: To examine the in vitro invasiveness of synoviocytes obtained from inflamed joints of patients with arthritis in relation to the expression of MMP 1...article 2002
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- Spruit, W.E.T. (author), Trap, H.C. (author), Langenberg, J.P. (author), Benschop, H.P. (author) article 2001
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Scholten, N.P.M. (author), de Groot-Van Dam, A. (author), Kortman, J.G.M. (author), Huppes, G. (author), van der Ven, B. (author), Schuurmans, A. (author), Anink, D. (author)After consulting the building industry the Dutch government decided in February 1998 to implement sustainability requirements in the Dutch Building Decree by the year 2001. Part of these requirements will be the material-based environmental performance of a building, mepb.. An energy performance requirement for buildings is already part of the...conference paper 2001
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Noort, D. (author), Hulst, A.G. (author), Fidder, A. (author), van Gurp, R.A. (author), de Jong, L.P.A. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)The development of procedures for retrospective detection and quantitation of exposure to phosgene, based on adducts to hemoglobin and albumin, is described. Upon incubation of human blood with [14C]phosgene (0-750 μM), a significant part of radioactivity (0-13%) became associated with globin and albumin. Upon Pronase digestion of globin, one of...article 2000
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van der Schans, G.P. (author), Haring, R. (author), van Dijk- Knijnenburg, H.C.M. (author), Bruijnzeel, P.L.B. (author), den Daas, N.H.G. (author)An immunochemical assay has been developed to detect oxidative damage in bovine sperm DNA. Sperm DNA contains a large amount of oxidative damage as a result of exposure to exogenous agents, but damage also can caused by normal metabolic processes and the absence of DNA repair in the later stages of spermatogenesis. A freeze-thaw procedure...article 2000
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Brunt, K. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This paper describes the collaborative study for establishing the repeatability and reproducibility of a recently developed new enzymatic starch determination. The ring test was in accordance to the ISO 5725 requirements for interlaboratory studies. The interlaboratory test resulted in a good relative repeatability of 1-2% and a relative...article 2000
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TNO Biomedical Instrumentation (author), van Popele, N.M. (author), Bos, W.J.W. (author), de Beer, N.A.M. (author), van der Kuip, D.A.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Witteman, J.C.M. (author)Oscillometric blood pressure devices tend to overestimate systolic blood pressure and underestimate diastolic blood pressure compared with sphygmomanometers. Recent studies indicate that discrepancies in performance between these devices may differ between healthy and diabetic subjects. Arterial stiffness in diabetics could be the underlying...article 2000
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TNO Preventie en Gezondheid (author), Boomsma, D.I. (author), Beem, A.L. (author), van den Berg, M. (author), Dolan, C.V. (author), Koopmans, J.R. (author), Vink, J.M. (author), de Geus, E.J.C. (author), Slagboom, P.E. (author)In a longitudinal study of Dutch adolescent and young adult twins, their parents and their siblings, questionnaire data were collected on depression, anxiety and correlated personality traits, such as neuroticism. Data were collected by mailed surveys in 1991, 1993, 1995 and 1997. A total of 13 717 individuals from 3344 families were included in...article 2000
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Pots, A.M. (author), Gruppen, H. (author), van Diepenbeek, R. (author), van der Lee, J.J. (author), van Boekel, M.A.J.S. (author), Wijngaards, G. (author), Voragen, A.G.J. (author)The content and biological activity of patatin and the protease inhibitors of molecular size 20-22 kDa present in whole potato tubers were investigated as a function of storage time. The amount of buffer-extractable protein decreased gradually during storage of whole potatoes of the cultivars Bintje and Desiree for 47 weeks whereas, for Elkana,...article 1999
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Mol, H.G.J. (author), van Dam, R.C.J. (author), Vreeken, R.J. (author), Steijger, O.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A straightforward and efficient method was developed for the determination of intact daminozide in apples and apple leaves. After extraction with methanol and a clean-up step using a graphitized carbon cartridge, the extract was analysed by ion-trap liquid chromatography-tandem mass spectrometry (LC-MS-MS) using atmospheric pressure chemical...article 1999
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Scholten, N.P.M. (author), TNO Bouw (author)In February 1998 the Dutch government decided to implement sustainability re-quirements by the year 2001 in the Dutch building Decree. Part of these require-ments shall be a performance requirement for the environmental influence of the total use of materials, determined by LCA (life cycle analyses), for dwellings or residential buildings. In...conference paper 1999
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Knebel, N.G. (author), Grieb, S. (author), Winkler, M. (author), Locher, M. (author), van der Vlis, E. (author), Verheij, E.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)An HPLC assay with tandem mass spectrometric detection in the positive-ion Turbo-Ion-Spray((TM)) (TISP) mode for the fast and sensitive determination of perifosine ((I), D-21266) in human plasma was developed, utilising the structural analogue, miltefosine ((II), D-18506), as internal standard. Automated solid-phase extraction of diluted plasma...article 1999
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Koppelman, S. (author), Knulst, A.C. (author), Koers, W.J. (author), Penninks, A.H. (author), Peppelman, H. (author), Vlooswijk, R. (author), Pigmans, I. (author), van Duijn, G. (author), Hessing, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Hazelnuts are widely used in the food industry owing to their nutritive value and taste. The amount of hazelnut present in a recipe is usually considered as a mark of quality. On the other hand, contamination of foods that normally do not contain hazelnuts is a threat for patients with a hazelnut allergy. For this reason, the availability of a...article 1999
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Schenk, H. (author), Driessen, R.A.J. (author), de Gelder, R. (author), Goubitz, K. (author), Nieboer, H. (author), Brüggemann-Rotgans, I.E.M. (author), Diepenhorst, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Potato crops can be severely damaged by potato cyst nematodes Globodera rostochiensis and Globodera pallida, nematodes highly specific to potatoes and some other Solanaceae. Hatching of juveniles is controlled by agents excreted by the roots of some Solanaceae species. Over seventy years much effort has been expended by many groups to isolate...article 1999