Searched for: subject%3A%22Dermal%255C%2Bexposure%22
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Marquart, H. (author), Warren, N.D. (author), Laitinen, J. (author), van Hemmen, J.J. (author), TNO Kwaliteit van Leven (author)
Dermal exposure needs to be addressed in regulatory risk assessment of chemicals. The models used so far are based on very limited data. The EU project RISKOFDERM has gathered a large number of new measurements on dermal exposure to industrial chemicals in various work situations, together with information on possible determinants of exposure....
article 2006
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Warren, N.D. (author), Marquart, H. (author), Christopher, Y. (author), Laitinen, J. (author), van Hemmen, J.J. (author), TNO Kwaliteit van Leven (author)
The regulatory risk assessment of chemicals requires the estimation of occupational dermal exposure. Until recently, the models used were either based on limited data or were specific to a particular class of chemical or application. The EU project RISKOFDERM has gathered a considerable number of new measurements of dermal exposure together with...
article 2006
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van Wendel de Joode, B. (author), van Hemmen, J.J. (author), Meijster, T. (author), Major, V. (author), London, L. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)
Valid and reliable semi-quantitative dermal exposure assessment methods for epidemiological research and for occupational hygiene practice, applicable for different chemical agents, are practically nonexistent. The aim of this study was to assess the reliability of a recently developed semi-quantitative dermal exposure assessment method (DREAM)...
article 2005
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van Wendel de Joode, B. (author), Tielemans, E. (author), Vermeulen, R. (author), Wegh, H. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)
Charcoal cloth pads have been used to assess volatile chemicals on the skin in a laboratory setting; however, they have not yet been applied to measure dermal exposure in occupational settings. This study aimed at evaluating whether charcoal pads can be used to assess dermal exposure to benzene and toluene in workers of a petrochemical plant....
article 2005
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Rajan-Sithamparanadarajah, R. (author), Roff, M. (author), Delgado, P. (author), Eriksson, K. (author), Fransman, W. (author), Gijsbers, J.H.J. (author), Hughson, G. (author), Mäkinen, M. (author), van Hemmen, J.J. (author), TNO Voeding (author)
Workplace dermal exposure assessment is a complex task that aims to understand the dynamic interaction between the skin and the hazardous substances present in the surrounding environment. A European project known as RISKOFDERM gathered dermal exposure data in 85 workplaces (industrial and other types) in five countries in Europe. In order to...
article 2004
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Gijsbers, J.H.J. (author), Tielemans, E. (author), Brouwer, D.H. (author), van Hemmen, J.J. (author), TNO Voeding (author)
Introduction: Limited quantitative information is available on dermal exposure to chemicals during various industrial activities. Therefore, within the scope of the EU-funded RISKOFDERM project, potential dermal exposure was measured during three different tasks: filling, loading and brushing. DEGBE (2-(2-butoxyethoxy)ethanol) was used as a ...
article 2004
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Kromhout, H. (author), Fransman, W. (author), Vermeulen, R. (author), Roff, M. (author), van Hemmen, J.J. (author), TNO Voeding (author)
Introduction: The RISKOFDERM project collected task-based estimates of potential dermal exposure from a wide range of industries and services from around Europe. A formal statistical analysis was carried out to explore the main components of variability in dermal exposure levels. The central research question was to what extent dermal exposure...
article 2004
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Kezic, S. (author), Meuling, W.J.A. (author), Jakasa, I. (author), TNO Voeding (author)
Objectives: To assess excretion kinetics of free and total (free + conjugated) 2-butoxyacetic acid (BAA) following dermal and inhalation exposure to butoxyethanol (BE). Methods: Six male volunteers were derma lly exposed for 4 h to a 50% aqueous solution of BE on an area of 40 cm2 of the volar forearm. Six other male volunteers were exposed by...
article 2004
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van Wendel de Joode, B. (author), Brouwer, D.H. (author), Kromhout, H. (author), van Hemmen, J.J. (author), TNO Voeding (author)
This paper describes a new method (DREAM) for structured, semi-quantitative dermal exposure assessment for chemical or biological agents that can be used in occupational hygiene or epidemiology. It is anticipated that DREAM could serve as an initial assessment of dermal exposure, amongst others, resulting in a ranking of tasks and subsequently...
article 2003
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Warren, N. (author), Goede, H.A. (author), Tijssen, S.C.H.A. (author), Oppl, R. (author), Schipper, H.J. (author), van Hemmen, J.J. (author), TNO Voeding (author)
This paper describes the derivation of default task-based dermal exposure values for use in a risk assessment toolkit for small and medium-sized enterprises (SMEs). A set of separately determined dermal exposure modifiers have been applied to published studies of dermal exposure to obtain 'normalized' dermal exposure data sets. These data sets...
article 2003
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van Hemmen, J.J. (author), Auffarth, J. (author), Evans, P.G. (author), Rajan-Sithamparanadarajah, B. (author), Marquart, H. (author), Oppl, R. (author), TNO Voeding (author)
Dermal exposure to industrial chemicals during work is of major concern in the risk assessment of chemicals. Current approaches in procedures for European legislation are not based on experimental data on dermal exposures in workplaces because these are lacking. A large project, with four interrelated work parts, was funded by the European...
article 2003
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Goede, H.A. (author), Tijssen, S.C.H.A. (author), Schipper, H.J. (author), Warren, N. (author), Oppl, R. (author), Kalberlah, F. (author), van Hemmen, J.J. (author), TNO Voeding (author)
This paper describes how default dermal exposure values can be adjusted with modifier values for specific work situations. The work presented here is supplementary to a toolkit developed for the EU RISKOFDERM project. This toolkit is intended for the assessment and management of dermal risks in small and medium sized enterprises. Potential...
article 2003
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Marquart, J. (author), Brouwer, D.H. (author), Gijsbers, J.H.J. (author), Links, I.H.M. (author), Warren, N. (author), van Hemmen, J.J. (author), TNO Voeding (author)
Risk assessment of chemicals requires assessment of the exposure levels of workers. In the absence of adequate specific measured data, models are often used to estimate exposure levels. For dermal exposure only a few models exist, which are not validated externally. In the scope of a large European research programme, an analysis of potential...
article 2003
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Oppl, R. (author), Kalberlah, F. (author), Evans, P.G. (author), van Hemmen, J.J. (author), TNO Voeding (author)
The European Research project RISKOFDERM (QLK4-CT-1999-01107) has two major goals. One is the development of a conceptual model for dermal risk assessment for regulatory purposes, such as the registration of new chemicals. The other goal is to develop a simple-to-use toolkit for assessment and management of health risks from occupational dermal...
article 2003
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Semple, S. (author), Brouwers, D.H. (author), Dick, F. (author), Cherrie, J.W. (author), TNO Voeding (author)
The contribution of dermal exposure to the total body burden of a given chemical is difficult to assess. However, it is possible that as regulatory pressures lead to reductions in inhalation exposure, the proportion of uptake via the dermal route will increase. This study brings together recent work in the field of dermal exposure to provide a...
article 2001
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Marquart, H. (author), Maidment, S. (author), Mcclaflin, J.L. (author), Fehrenbacher, M.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Dermal exposure assessment and modeling is still in early phases of development. This article presents the results of a workshop organized to harmonize the future needs in this field. Methods for dermal exposure assessment either assess the mass of contaminant that is transferred to the skin, or the transfer of contaminant through the skin....
article 2001
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Cherrie, J.W. (author), Brouwer, D.H. (author), Roff, M. (author), Vermeulen, R. (author), Kromhout, H. (author)
Fluorescent tracers provide a way of simultaneously assessing the mass of a contaminant hazardous substance on the surface of the skin of a worker and the area of skin exposed. These parameters, along with the duration of exposure and the estimated contaminant concentration in the skin contamination layer, can be used to calculate the likely...
article 2000
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Brouwer, D.H. (author), Lansink, C.M. (author), Cherrie, J.W. (author), van Hemmen, J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The range of dermal exposure to non-volatile compounds during spray painting was studied in a semi-experimental study involving three enterprises and 12 painters. A fluorescent tracer was added to the paint and deposition of the tracer on clothing and uncovered parts of the skin was assessed using video imaging and processing techniques. A...
article 2000
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Kromhout, H. (author), Hoek, F. (author), Uitterhoeve, R. (author), Huijbers, R. (author), Overmars, R.F. (author), Anzion, R. (author), Vermeulen, R. (author)
Dermal exposure to anti-neoplastic drugs has been suggested as a potentially important route of exposure of hospital workers. Three small-scale workplace surveys were carried out in several hospitals focusing on contamination by leakage from IV infusion systems; contamination by spilled urine of patients treated with anti-neoplastic drugs and...
article 2000
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van Hemmen, J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In a project granted by DG XI of the European Commission, it is attempted to collate experimental and theoretical data on human (workers and consumers) exposure assessment to biocidal products, and to outline the methodology for sampling and measurement. On the basis of the available evidence, approaches are presented for the exposure assessment...
article 1999
Searched for: subject%3A%22Dermal%255C%2Bexposure%22
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