Searched for: subject:"Delayed%5C+hypersensitivity"
(1 - 10 of 10)
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Penninks, A.H. (author), Waalkens - Berendsen, I.D.H. (author), Wolterbeek, A.P.M. (author), Slob, W. (author), Piersma, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Current developmental and reproductive toxicity protocols include only a limited set of parameters for effects on the developing immune system. In this study, a wide range of immunological parameters were included in a pre- and postnatal developmental toxicity study. Dose-response data were compared to determine the relative sensitivity of...
article 2010
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Kel, J.M. (author), Slütter, B. (author), Drijfhout, J.W. (author), Koning, F. (author), Nagelkerken, L. (author), TNO Kwaliteit van Leven (author)
Tolerance to experimental autoimmune encephalomyelitis (EAE) in SJL mice can be induced by immunization with a mannosylated form of the proteolipid protein (M-PLP139-151), despite the presence of CFA. The state of tolerance is characterized by poor delayed-type hypersensitivity responses and the absence of clinical EAE symptoms. In vivo...
article 2008
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Kel, J.M. (author), de Geus, E.D. (author), van Stipdonk, M.J. (author), Drijfhout, J.W. (author), Koning, F. (author), Nagelkerken, L. (author), TNO Kwaliteit van Leven (author)
In this study, we investigated the development of T cell responses in mice after administration of a mannosylated ovalbumin peptide (M-OVA323-339). Immunization with M-OVA323-339 in complete adjuvant resulted in enhanced antigen presentation in draining lymph nodes. Monitoring the fate of CFSE-labeled ovalbumin peptide-specific TCR transgenic...
article 2008
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Verbeek, R. (author), van der Mark, K. (author), Wawrousek, E.F. (author), Plomp, A.C. (author), van Noort, J.M. (author), TNO Kwaliteit van Leven (author)
Tolerance induction to prevent activation of a naïve T-cell repertoire has been well documented in rodents and can be readily achieved by intravenous, oral or intranasal administration of antigen in the absence of adjuvants. In autoimmune diseases such as multiple sclerosis (MS) the presence of an established memory/effector T-cell repertoire...
article 2007
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Lehé, C.L. (author), Jacobs, J.J.L. (author), Hua, C.M. (author), Courtellemont, P. (author), Elliott, G.R. (author), Das, P.K. (author), TNO Defensie en Veiligheid (author)
The accelerated migration of Langerhans cells (LCs) out of the epidermis and up-regulation of maturation markers, upon treatment with subtoxic concentrations of chemicals, were used as the criteria to determine the potential of allergenic chemicals capable of inducing a hapten-specific delayed-type hypersensitivity reaction. Here we report the...
article 2006
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Luca, M.E. (author), Kel, J.M. (author), van Rijs, W. (author), Drijfhout, J.W. (author), Koning, F. (author), Nagelkerken, L. (author), Gaubius Instituut TNO (author)
SJL mice immunized with mannosylated (M-) PLP139-151 in complete adjuvant do not develop EAE and little CNS mononuclear cell infiltration; other mannosylated peptides were ineffective in this experimental setting. Despite apparently normal T cell responses, M-PLP139-151-immunized mice show impaired delayed-type-sensitivity to PLP139-151 but a...
article 2005
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Geutskens, S.B. (author), van der Eb, M.M. (author), Plomp, A.C. (author), Jonges, L.E. (author), Cramer, S.J. (author), Ensink, N.G. (author), Kuppen, P.J.K. (author), Hoeben, R.C. (author)
The host-immune response against adenoviruses forms a major obstacle for their use as gene therapy vectors for treatment of genetic defects. None the less, they are the preferred vectors for in vivo gene transfer in experimental gene therapy protocols for cancer. In this article we demonstrate the antitumor efficacy of adenovirus-mediated...
article 2000
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Knippels, L.M.J. (author), Penninks, A.H. (author), van Meeteren, M. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
No adequate enteral sensitization models are available to study food allergy and allergenicity of food proteins. Using a previously described oral sensitization protocol to sensitize Brown Norway rats (BN) to food proteins, the influence of genetically-based strain-specific characteristics of the immune system on the outcome of oral...
article 1999
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Chua-Intra, B. (author), Ivanyi, J. (author), Hills, A. (author), Thole, J. (author), Moreno, C. (author), Vordermeier, H.M. (author), TNO Preventie en Gezondheid (author)
The Mycobacterium leprae and M. tuberculosis 10000 MW heat-shock protein homologues of GroES have previously been identified as major immunogens for human T cells. We used synthetic peptides to characterize the determinants recognized by murine T cells. The findings suggest that, despite 90% sequence identity between these two proteins, T cells...
article 1998
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Knippels, L.M.J. (author), Penninks, A.H. (author), Spanhaak, S. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Although several in vivo antigenicity assays using parenteral immunization are operational, no adequate enteral sensitization models are available to study food allergy and allergenicity of food proteins. Objective: This paper describes the development of an enteral model for food allergy research in the Brown Norway (BN) rat....
article 1998
Searched for: subject:"Delayed%5C+hypersensitivity"
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