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Krishnan, S. (author), Vermeulen, R. (author), Pronk, A. (author), Gyori, B.M. (author), Bachman, J.A. (author), Vlaanderen, J. (author), Stierum, R. (author)BACKGROUND: Mechanistic data is increasingly used in hazard identification of chemicals. However, the volume of data is large, challenging the efficient identification and clustering of relevant data. OBJECTIVES: We investigated whether evidence identification for hazard assessment can become more efficient and informed through an automated...article 2022
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Stroek, K. (author), Heijboer, A.C. (author), Bouva, M.J. (author), van der Ploeg, C.P.B. (author), Heijnen, M.L.A. (author), Weijman, G. (author), Bosch, A.M. (author), de Jonge, R. (author), Schielen, P.C.J.I. (author), van Trotsenburg, A.S.P. (author), Boelen, A. (author)Objective: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency at birth due to disorders of the thyroid gland (thyroidal CH, CH-T), or the hypothalamus or pituitary (central CH, CH-C). The Dutch Newborn Screening (NBS) strategy is primarily based on determination of thyroxine (T4) concentrations in dried blood spots followed,...article 2020
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van Buuren, S. (author), Bezemer, R.A. (author), Reijneveld, S.A. (author), L' Hoir, M.P. (author)Curve matching is a new big data technique to predict an outcome given earlier measurements. Here we apply curve matching to predict the future growth of a specific child, the target child. The method searches in large datasets of longitudinal growth data for other children who are similar to the target child in terms of factors that influence...article 2015
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Hettne, K.M. (author), Boorsma, A. (author), van Dartel, D.A.M. (author), Goeman, J.J. (author), de Jong, E. (author), Piersma, A.H. (author), Stierum, R.H. (author), Kleinjans, J.C. (author), Kors, J.A. (author)Background: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set analysis (GSA) methods for chemical treatment...article 2013
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van de Ven, P. (author), Fransman, W. (author), Schinkel, J. (author), Rubingh, C. (author), Warren, N. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)The web-based tool "Stoffenmanager" was initially developed to assist small- and medium-sized enterprises in the Netherlands to make qualitative risk assessments and to provide advice on control at the workplace. The tool uses a mechanistic model to arrive at a "Stoffenmanager score" for exposure. In a recent study it was shown that variability...article 2010
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TNO Kwaliteit van Leven (author), Molag, M.L. (author), de Vries, J.H.M. (author), Duif, N. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), Goldbohm, R.A. (author), van 't Veer, P. (author)The authors automated the selection of foods in a computer system that compiles and processes tailored FFQ. For the selection of food items, several methods are available. The aim of the present study was to compare food lists made by MOM2, which identifies food items with highest between-person variance in intake of the nutrients of interest...article 2010
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Schaafsma, G. (author), Kroese, E.D. (author), Tielemans, E.L.J.P. (author), van de Sandt, J.J.M. (author), van Leeuwen, C.J. (author), TNO Kwaliteit van Leven (author)The objectives of REACH cannot be achieved under the current risk assessment approach. A change in mind set among all the relevant stakeholders is needed: risk assessment should move away from a labor-intensive and animal-consuming approach to intelligent and pragmatic testing, by combining exposure and hazard data effectively and trying to...article 2009
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TNO Kwaliteit van Leven (author), Thissen, U. (author), Wopereis, S. (author), van den Berg, S.A.A. (author), Bobeldijk, I. (author), Kleemann, R. (author), Kooistra, T. (author), van Dijk, K.W. (author), van Ommen, B. (author), Smilde, A.K. (author)Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study design can be used to decompose the total data...article 2009
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Werf, M.J.v.d. (author), Overkamp, K.M. (author), Muilwijk, B. (author), Coulier, L. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)Achieving metabolome data with satisfactory coverage is a formidable challenge in metabolomics because metabolites are a chemically highly diverse group of compounds. Here we present a strategy for the development of an advanced analytical platform that allows the comprehensive analysis of microbial metabolomes. Our approach started with in...article 2007
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Tielemans, E. (author), Warren, N. (author), Schneider, T. (author), Tischer, M. (author), Ritchie, P. (author), Goede, H. (author), Kromhout, H. (author), van Hemmen, J. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)REACH (Registration, Evaluation and Authorization of CHemicals) requires improved exposure models that can be incorporated into screening tools and refined assessment tools. These are referred to as tier 1 and 2 models, respectively. There are a number of candidate in tier 1 models that could be used with REACH. Tier 2 models, producing robust...article 2007
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Slimani, N. (author), Deharveng, G. (author), Unwin, I. (author), Southgate, D.A.T. (author), Vignat, J. (author), Skeie, G. (author), Salvini, S. (author), Parpinel, M. (author), Møller, A. (author), Ireland, J. (author), Becker, W. (author), Farran, A. (author), Westenbrink, S. (author), Vasilopoulou, E. (author), Unwin, J. (author), Borgejordet, Å. (author), Rohrmann, S. (author), Church, S. (author), Gnagnarella, P. (author), Casagrande, C. (author), van Bakel, M. (author), Niravong, M. (author), Boutron-Ruault, M.C. (author), Stripp, C. (author), Tjønneland, A. (author), Trichopoulou, A. (author), Georga, K. (author), Nilsson, S. (author), Mattisson, I. (author), Ray, J. (author), Boeing, H. (author), Ocké, M. (author), Peeters, P.H.M. (author), Jakszyn, P. (author), Amiano, P. (author), Engeset, D. (author), Lund, E. (author), Santucci de Magistris, M. (author), Sacerdote, C. (author), Welch, A. (author), Bingham, S. (author), Subar, A.F. (author), Riboli, E. (author), TNO Kwaliteit van Leven (author)Objective: This paper describes the ad hoc methodological concepts and procedures developed to improve the comparability of Nutrient databases (NDBs) across the 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). This was required because there is currently no European reference NDB...article 2007
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Fiehn, O. (author), Kristal, B. (author), van Ommen, B. (author), Sumner, L.W. (author), Sansone, S.-A. (author), Taylor, C. (author), Hardy, N. (author), Kaddurah-Daouk, R. (author), TNO Kwaliteit van Leven (author)Metabolite concentrations in cellular systems are very much dependent on the physiological, environmental, and genetic status of an organism and are regarded as the ultimate result of cellular regulation, resulting in the visible phenotypes. Therefore, the comprehensive analysis of metabolite levels and fluxes renders a suitable tool for...article 2006
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Kiely, M. (author), Faughnan, M. (author), Wähälä, K. (author), Brants, H. (author), Mulligan, A. (author)The objective of the Vegetal Estrogens in Nutrition and the Skeleton (VENUS) project was to evaluate existing data on dietary exposure to compounds with oestrogenic and anti-oestrogenic effects present in plant foods as constituents or contaminants, and to identify and disseminate in vitro and in vivo methodologies to analyse the effects of such...article 2003
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Ireland, J. (author), Erp-Baart, A.M.J. (author), Charrondière, U.R. (author), Moller, A. (author), Smithers, G. (author), Trichopoulou, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To harmonize food classification and food composition databases, allowing comparability of consumption at both food and nutrient levels in Europe. Design: To establish the level of comparability at the food level, the EFCOSUM group benefited from the work already carried out within other European projects, which established a Euro...article 2002
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Brussaard, J.H. (author), Johansson, L. (author), Kearney, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To describe the rationale and methods for a European project (EFCOSUM) to develop a method for a European food consumption survey that delivers internationally comparable data on a set of policy-relevant nutritional indicators. Rationale and methods: Currently Member States are collecting data and information for use at national level...article 2002
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Rennen, M.A.J. (author), Nordheim, K. (author), Houben, G.F. (author), de Heer, C. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Health risks resulting from occupational exposure to chemicals are controlled by the establishment of acceptable dermal and respiratory exposure levels. Due to a lack of route-specific toxicity data, acceptable levels are frequently established by means of route-to-route extrapolation. A pitfall in route-to-route extrapolation is the occurrence...article 2002
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Anthony, S. (author), van der Pal-de Bruin, K.M. (author), Graafmans, W.C. (author), Dorrepaal, C.A. (author), Borkent-Polet, M. (author), van Hemel, O.J.S. (author), Jansen, F.H.M. (author), den Lya Ouden, A. (author), TNO Preventie en Gezondheid (author)Official Dutch perinatal mortality rates are based on birth and death certificates. These civil registration data are not detailed enough for international comparisons or extensive epidemiological research. In this study, we linked and extrapolated three national incomplete, professional registers from midwives, obstetricians and paediatricians,...article 2001
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van Hemmen, J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)For registration of agricultural pesticides, the risks for humans, animals, and the environment must be determined. The risk assessment is based on an appraisal of the levels of exposure and the hazards of the active substance(s) in the plant protection product, that is, the agricultural pesticide. Funded by the European Commission (AIR3 CT93...article 2001
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), O'Neill, M.E. (author), Carroll, Y. (author), Corridan, B. (author), Olmedilla, B. (author), Granado, F. (author), Blanco, I. (author), van den Berg, H. (author), Hininger, I. (author), Rousell, A.M. (author), Chopra, M. (author), Southon, S. (author), Thurnham, D.I. (author)A food frequency questionnaire (FFQ) and carotenoid database with information on alpha- and beta-carotene, lutein, lycopene and beta-cryptoxanthin was prepared and used to compare the carotenoid intakes in five European countries: UK, Republic of Ireland, Spain, France and The Netherlands. Eighty, age- (25-45 years) and sex-matched volunteers...article 2001
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Lambe, J. (author), Kearney, J. (author), Becker, W. (author), Hulshof, K. (author), Dunne, A. (author), Gibney, M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To examine the hypothesis that there is sufficient agreement between percentage of households purchasing selected foods using household budget surveys and percentage of individuals consuming these foods as determined in individual-based surveys to allow the former to act as a surrogate for the latter when estimating food chemical...article 1998
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