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Corthésy-Theulaz, I. (author), den Dunnen, J.T. (author), Ferré, P. (author), Geurts, J.M.W. (author), Müller, M. (author), van Belzen, N. (author), van Ommen, B. (author), TNO Kwaliteit van Leven (author)The interaction between the human body and nutrition is an extremely complex process involving multi-organ physiology with molecular mechanisms on all levels of regulation (genes, gene expression, proteins, metabolites). Only with the recent technology push have nutritional scientists been able to address this complexity. Both the challenges and...article 2005
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Lintsen, A.M.E. (author), de Pasker-Jong, P.C.M. (author), de Boer, E.J. (author), Burger, C.W. (author), Jansen, C.A.M. (author), Braat, D.D.M. (author), van Leeuwen, F.E. (author), Kortman, M. (author), te Velde, E.R. (author), Macklon, N. (author), Jansen, C.A.M. (author), Leerentveld, R.A. (author), Willemsen, W.N.P. (author), Schats, R. (author), Naaktgeboren, N. (author), Helmerhorst, F.M. (author), Bots, R.S.G.M. (author), Simons, A.H.M. (author), Hogerzeil, H.V. (author), Evers, J.L.H. (author), van Dop, P.A. (author), TNO Kwaliteit van Leven (author)Background: We investigated the separate and combined effects of smoking and body mass index (BMI) on the success rate of IVF for couples with different causes of subfertility. Methods: The success rate of IVF was examined in 8457 women. Detailed information on reproduction and lifestyle factors was combined with medical record data on IVF...article 2005
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Jansen, J.J. (author), Hoefsloot, H.C.J. (author), van der Greef, J. (author), Timmerman, M.E. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)Genomics-based technologies in systems biology have gained a lot of popularity in recent years. These technologies generate large amounts of data. To obtain information from this data, multivariate data analysis methods are required. Many of the datasets generated in genomics are multilevel datasets, in which the variation occurs on different...article 2005
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Verhoeckx, K.C.M. (author), Gaspari, M. (author), Bijlsma, S. (author), van der Greef, J. (author), Witkamp, R.F. (author), Doornbos, R.P. (author), Rodenburg, R.J.T. (author), TNO Kwaliteit van Leven (author)Two-dimensional difference gel electrophoresis (DIGE) in combination with univariate (Student's t-test) and multivariate data analysis, principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were used to study the anti-inflammatory effects of the β2-adrenergic receptor (β2-AR) agonist zilpaterol. U937...article 2005
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Brink, M. (author), Weijenberg, M.P. (author), de Goeij, A.F.P.M. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), de Bruïne, A.P. (author), van Engeland, M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)We studied the association between dietary folate and specific K-ras mutations in colon and rectal cancer in The Netherlands Cohort Study on diet and cancer. After 7.3 years of follow-up, 448 colon and 160 rectal cancer patients and 3,048 sub-cohort members (55-69 years at baseline) were available for data analyses. Mutation analysis of the K...article 2005
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Adams, T.B. (author), Cohen, S.M. (author), Doull, J. (author), Feron, V.J. (author), Goodman, J.I. (author), Marnett, L.J. (author), Munro, I.C. (author), Portoghese, P.S. (author), Smith, R.L. (author), Waddell, W.J. (author), Wagner, B.M. (author), TNO Kwaliteit van Leven (author)This publication is the ninth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the...article 2005
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Lamers, R.J.A.N. (author), van Nesselrooij, J.H.J. (author), Kraus, V.B. (author), Jordan, J.M. (author), Renner, J.B. (author), Dragomir, A.D. (author), Luta, G. (author), van der Greef, J. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)Objective: Osteoarthritis (OA) is one of the most common diseases among the elderly. The main characteristic is the progressive destruction of articular cartilage. We lack quantitative and sensitive biomarkers for OA to detect changes in the joints in an early stage of the disease. In this study, we investigated whether a urinary metabolite...article 2005
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Smilde, A.K. (author), van der Werf, M.J. (author), Bijlsma, S. (author), van der Werff-van der Vat, B.J.C. (author), Jellema, R.H. (author), TNO Kwaliteit van Leven (author)A general method is presented for combining mass spectrometry-based metabolomics data. Such data are becoming more and more abundant, and proper tools for fusing these types of data sets are needed. Fusion of metabolomics data leads to a comprehensive view on the metabolome of an organism or biological system. The ideas presented draw upon...article 2005
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Adams, T.B. (author), Cohen, S.M. (author), Doull, J. (author), Feron, V.J. (author), Goodman, J.I. (author), Marnett, L.J. (author), Munro, I.C. (author), Portoghese, P.S. (author), Smith, R.L. (author), Waddell, W.J. (author), Wagner, B.M. (author), TNO Kwaliteit van Leven (author)This publication is the ninth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the...article 2005
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van Erk, M.J. (author), Krul, C.A.M. (author), Caldenhoven, E. (author), Stierum, R.H. (author), Peters, W.H. (author), Woutersen, R.A. (author), van Ommen, B. (author), TNO Kwaliteit van Leven TNO Voeding (author)Interest in mechanisms of colon cancer prevention by food compounds is strong and research in this area is often performed with cultured colon cancer cells. In order to assess utility for screening of potential cancer-preventive (food) compounds, expression profiles of 14 human cell lines derived from colonic tissue were measured using cDNA...article 2005
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Witkamp, R.F. (author), TNO Kwaliteit van Leven (author)This review discusses some of the recent developments in genomics and its current and future relevance for veterinary pharmacology and toxicology. With the rapid progress made in this field several new approaches in pharmacological and toxicological research have developed and drug discovery and drug development strategies have changed...article 2005
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Smilde, A.K. (author), Jansen, J.J. (author), Hoefsloot, H.C.J. (author), Lamers, R.J.A.N. (author), van der Greef, J. (author), Timmerman, M.E. (author), TNO Kwaliteit van Leven (author)Motivation: Datasets resulting from metabolomics or metabolic profiling experiments are becoming increasingly complex. Such datasets may contain underlying factors, such as time (time-resolved or longitudinal measurements), doses or combinations thereof. Currently used biostatistics methods do not take the structure of such complex datasets into...article 2005
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Lanting, C.I. (author), van Wouwe, J.P. (author), Reijneveld, S.A. (author)Aim: The aim of the study was to describe infant feeding practices and associated factors, and to explore mothers' main reasons for starting and stopping breastfeeding. Methods: We performed a national inquiry into milk feeding practices among 9133 Dutch infants aged <7 mo by means of a questionnaire. Results: 78% of mothers initiated...article 2005
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Adams, T.B. (author), Cohen, S.M. (author), Doull, J. (author), Feron, V.J. (author), Goodman, J.I. (author), Marnett, L.J. (author), Munro, I.C. (author), Portoghese, P.S. (author), Smith, R.L. (author), Waddell, W.J. (author), Wagner, B.M. (author), TNO Kwaliteit van Leven (author)This publication is the eighth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to...article 2005
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Toet, A. (author), TNO Defensie en Veiligheid (author)Modern complex surveillance systems consisting of multiple and heterogeneous sensors, automatic information registration and data analysis techniques, and decision support tools should provide the human operator an integrated, transparent and easily comprehensible view of the surveyed scene. Displayed visual information should be optimally tuned...conference paper 2005
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van Teeffelen, A.M.M. (author), Meinders, M.B.J. (author), de Jongh, H.H.J. (author), TNO Kwaliteit van Leven (author)Information on changes in heat capacity (ΔCp) of proteins upon unfolding is used frequently in literature to understand possible follow-up reactions of protein denaturation, like their aggregation propensity. This thermodynamic property is intrinsic to the protein's architecture and unfolding and should be independent of the approach used to...article 2005
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Wang, M. (author), Lamers, R.J.A.N. (author), Korthout, H.A.A.J. (author), van Nesselrooij, J.H.J. (author), Witkamp, R.F. (author), van der Heijden, R. (author), Voshol, P.J. (author), Havekes, L.M. (author), Verpoorte, R. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)The introduction of the concept of systems biology, enabling the study of living systems from a holistic perspective based on the profiling of a multitude of biochemical components, opens up a unique and novel opportunity to reinvestigate natural products. In the study of their bioactivity, the necessary reductionistic approach on single active...article 2005
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de Lange, A.H. (author), Taris, T.W. (author), Kompier, M.A.J. (author), Houtman, I.L.D. (author), Bongers, P.M. (author)Objectives: The number of longitudinal studies reporting evidence for reversed effects of strain on work is growing, but evidence regarding the mechanisms underlying such effects is scarce. In this study, earlier longitudinal findings were reviewed, and the following four mechanisms for reversed effects were proposed that reflect within-person...article 2005
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Risk assessment of silicosis and lung cancer among construction workers exposed to respirable quartzTNO Kwaliteit van Leven TNO Voeding (author), Tjoe Nij, E. (author), Heederik, D. (author)Objectives: The aim of this study was to assess the magnitude of the silicosis and cancer risk among construction workers. Methods: In 1998, 1335 of 4173 invited construction workers with expected high cumulative exposure to quartz were studied for early signs of silicosis. In 2002 the study was repeated for 96 persons. Exposure measurements...article 2005
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van Hemmen, J.J. (author), TNO Voeding (author)An important shortcoming in our present knowledge required for risk assessment of biocidal products is the assessment of human exposure. This knowledge gap has been filled in a preliminary fashion with the TNsG on human exposure to biocidal products (available from the ECB website). Explicit User guidance has been developed by an expert group...article 2004