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TNO Kwaliteit van Leven (author), Beckers, D.G.J. (author), van Hooff, M.L.M. (author), van der Linden, D. (author), Kompier, M.A.J. (author), Taris, T.W. (author), Geurts, S.A.E. (author)Objectives: This study aimed at opening up the black box of overtime work among university faculty members by providing information on (i) when faculty members work overtime, (ii) what activities are undertaken during overtime, and (iii) how overtime is experienced. Methods: Data were collected among 120 Dutch faculty members who completed a...article 2008
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Wijlhuizen, G.J. (author), de Jong, R. (author), Hopman-Rock, M. (author), TNO Kwaliteit van Leven (author)Objective.: The aim of this study was to test the assumption that the level of outdoor physical activity mediates the relationship between fear of falling and actual outdoor falls according to the Task Difficulty Homeostasis Theory. Method.: A prospective follow-up study of 10 months conducted in the year 2000 in three municipalities in the...article 2007
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- Dousma, M. (author), Wierdsma, N. (author), van Ede, J. (author), van Buuren, S. (author), Heijmans, H.S.A. (author), de Vries, T.W. (author), TNO Kwaliteit van Leven (author) article 2007
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de Jonge, A. (author), van Diem, M.T. (author), Scheepers, P.L.H. (author), van der Pal-de Bruin, K.M. (author), Lagro-Janssen, A. (author), TNO Kwaliteit van Leven (author)Objective: To assess whether the risk of severe blood loss is increased in semi-sitting and sitting position, and if so, to which extent blood loss from perineal damage is responsible for this finding. Design: Secondary analysis of data from a large trial. Setting: Primary care midwifery practices in the Netherlands. Population: About 1646 low...article 2007
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Slimani, N. (author), Deharveng, G. (author), Unwin, I. (author), Southgate, D.A.T. (author), Vignat, J. (author), Skeie, G. (author), Salvini, S. (author), Parpinel, M. (author), Møller, A. (author), Ireland, J. (author), Becker, W. (author), Farran, A. (author), Westenbrink, S. (author), Vasilopoulou, E. (author), Unwin, J. (author), Borgejordet, Å. (author), Rohrmann, S. (author), Church, S. (author), Gnagnarella, P. (author), Casagrande, C. (author), van Bakel, M. (author), Niravong, M. (author), Boutron-Ruault, M.C. (author), Stripp, C. (author), Tjønneland, A. (author), Trichopoulou, A. (author), Georga, K. (author), Nilsson, S. (author), Mattisson, I. (author), Ray, J. (author), Boeing, H. (author), Ocké, M. (author), Peeters, P.H.M. (author), Jakszyn, P. (author), Amiano, P. (author), Engeset, D. (author), Lund, E. (author), Santucci de Magistris, M. (author), Sacerdote, C. (author), Welch, A. (author), Bingham, S. (author), Subar, A.F. (author), Riboli, E. (author), TNO Kwaliteit van Leven (author)Objective: This paper describes the ad hoc methodological concepts and procedures developed to improve the comparability of Nutrient databases (NDBs) across the 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). This was required because there is currently no European reference NDB...article 2007
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TNO Kwaliteit van Leven (author), Steevens, J. (author), Schouten, L.J. (author), Verhage, B.A.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)In a cohort study, ovarian cancer (280 cases) showed no significant association with tea or coffee, the multivariable rate ratios being 0.94 (95% confidence interval (CI): 0.89, 1.00) and 1.04 (95% CI: 0.97, 1.12) per cup per day, respectively. A meta-analysis also produced no significant findings overall, though the cohort studies showed a...article 2007
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TNO Kwaliteit van Leven (author), Hertsenberg, S. (author), Brouwer, D. (author), Lurvink, M. (author), Rubingh, C. (author), Rijnders, E. (author), Tielemans, E. (author)Self-assessment of exposure (SAE) refers to any exposure assessment methodology wherein the worker takes an active role in establishing his or her exposure status. The objective of this study was to investigate the reliability and feasibility of SAE approaches among shoe repair workers collecting exposure data over a 3 month period. This study...article 2007
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Robitail, S. (author), Simeoni, M.-C. (author), Erhart, M. (author), Ravens-Sieberer, U. (author), Bruil, J. (author), Auquier, P. (author), TNO Preventie en Gezondheid (author)Purpose: The KIDSCREEN project aims to develop a European cross-cultural generic self-administered Health-Related Quality of Life (HRQoL) instrument for children and adolescents. Proxy measures HRQoL should be a useful and practical alternative to assess children's HRQoL. The KIDSCREEN pilot study involved 3988 children and 2526 child-proxy...article 2006
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Fiehn, O. (author), Kristal, B. (author), van Ommen, B. (author), Sumner, L.W. (author), Sansone, S.-A. (author), Taylor, C. (author), Hardy, N. (author), Kaddurah-Daouk, R. (author), TNO Kwaliteit van Leven (author)Metabolite concentrations in cellular systems are very much dependent on the physiological, environmental, and genetic status of an organism and are regarded as the ultimate result of cellular regulation, resulting in the visible phenotypes. Therefore, the comprehensive analysis of metabolite levels and fluxes renders a suitable tool for...article 2006
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Breuning-Boers, J.M. (author), van Dommelen, P. (author), van Wouwe, J.P. (author), Verkerk, P.H. (author)Objective. To determine the relationship between serum sodium concentration and weight loss as well as residual symptoms in newborns with hypernatremic dehydration caused by insufficient breastfeeding; and to determine the sensitivity of the following rule of thumb 'if weight loss is less than 10%, the baby does not have hypernatremic...article 2006
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Goldbohm, R.A. (author), Tielemans, E.L.J.P. (author), Heederik, D. (author), Rubingh, C.M. (author), Dekkers, S. (author), Willems, M.I. (author), Dinant Kroese, E. (author), TNO Kwaliteit van Leven (author)It is generally recognized that human, epidemiological data, if available, are preferred as the starting point for quantitative risk analysis above the use of data from animal studies. Although methods to obtain proper risk estimates from epidemiological data are available, several impediments prevent their widespread application. These...article 2006
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Geng, Q. (author), Holme, I. (author), den Hartog, E.A. (author), Havenith, G. (author), Jay, O. (author), Malchaires, J. (author), Piette, A. (author), Rintama, H. (author), Rissanen, S. (author), TNO Defensie en Veiligheid (author)Objectives: At the request of the European Commission and in the framework of the European Machinery Directive, research was performed in five different laboratories to develop specifications for surface temperature limit values for the short-term accidental touching of the fingertip with cold surfaces. Methods: Data were collected in four...article 2006
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Coulier, L. (author), Kaal, E. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)Hyphenation of infrared spectroscopy (IR) to liquid chromatography (LC) has been applied to study chemical changes in poly(bisphenol A)carbonate (PC) as a result of degradation. Especially coupling of LC to FTIR through solvent elimination is a sensitive approach to identify changes in functionality observed in the LC chromatograms as has been...article 2006
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de Theije, P.A.M. (author), Sindt, J.C. (author), TNO Defensie en Veiligheid (author)This paper focuses on estimating the two-dimensional (2-D) target-speed vector (course and speed) using a multistatic sonar that consists of one monostatic sonar and one bistatic receiver. The speed and course estimates are obtained after a single transmission. The theory on bistatic Doppler and 2-D target-speed vector estimation is first...article 2006
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Clare, M.G. (author), Lorenzon, G. (author), Akhurst, L.C. (author), Marzin, D. (author), van Delft, J. (author), Montero, R. (author), Botta, A. (author), Bertens, A. (author), Cinelli, S. (author), Thybaud, V. (author), Lorge, E. (author), TNO Kwaliteit van Leven (author)This study on the in vitro micronucleus assay, comprising 11 laboratories using human lymphocytes, was coordinated by an organizing committee supported by the SFTG (the French branch of the European Environmental Mutagen Society). Nine coded substances were assessed for their ability to induce micronuclei in human lymphocytes in vitro, mitomycin...article 2006
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TNO Kwaliteit van Leven (author), van den Berg, R.A. (author), Hoefsloot, H.C.J. (author), Westerhuis, J.A. (author), Smilde, A.K. (author), van der Werf, M.J. (author)Background: Extracting relevant biological information from large data sets is a major challenge in functional genomics research. Different aspects of the data hamper their biological interpretation. For instance, 5000-fold differences in concentration for different metabolites are present in a metabolomics data set, while these differences are...article 2006
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TNO Kwaliteit van Leven (author), IJmker, S. (author), Blatter, B.M. (author), van der Beek, A.J. (author), van Mechelen, W. (author), Bongers, P.M. (author)Background: This article describes the background and study design of the PROMO study (Prospective Research on Musculoskeletal disorders in Office workers). Few longitudinal studies have been performed to investigate the risk factors responsible for the incidence of hand, arm, shoulder and neck symptoms among office workers, given the...article 2006
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TNO Kwaliteit van Leven (author), de Vries, S.I. (author), Bakker, I. (author), Hopman-Rock, M. (author), Hirasing, R.A. (author), van Mechelen, W. (author)Background and Objectives: To review the clinimetric quality of motion sensors used to assess physical activity in healthy children and adolescents (2-18 years). Methods: A systematic literature search was performed in PubMed, Embase, and SpycINFO. The clinimetric quality of two pedometers (Digi-Walker, Pedoboy), four one-dimensional...article 2006
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Hoeksma, M. (author), van Rijn, M. (author), Verkerk, P.H. (author), Bosch, A.M. (author), Mulder, M.F. (author), de Klerk, J.B.C. (author), de Koning, T.J. (author), Rubio-Gozalbo, E. (author), de Vries, M. (author), Sauer, P.J.J. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)In a previous study, Dutch children with phenylketonuria (PKU) were found to be slightly shorter than their healthy counterparts. In the literature, it has been hypothesized that a higher protein intake is necessary to optimize growth in PKU patients. The study aimed to investigate whether protein intake (total, natural and protein substitute)...article 2005
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van der Werf, M.J. (author), TNO Kwaliteit van Leven (author)Increasingly, microbial production processes are being improved by targeted approaches. In directed strain improvement, the selection of the relevant targets is the limiting step in metabolic engineering. Currently, the identification of leads is still a random process relying largely on expert knowledge. Recently, this approach has been...article 2005