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de Boer, M.H.T. (author), van Maanen, P.P. (author), Vreeswijk, G. (author)Intelligence analysts have to work in highly demanding circumstances. This causes mistakes with severe consequences, which is the reason that support systems for intelligence analysts have been developed. The support system proposed in this paper assists humans by offering support that improves their performance, without reducing them in their...conference paper 2013
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van der Veen, J.S. (author), van der Waaij, B. (author), Vonder, M. (author), de Jonge, M. (author), Lazovik, E. (author), Meijer, R.J. (author)Sensors have been used for many years to gather information about their environment. The number of sensors connected to the internet is increasing, which has led to a growing demand of data transport and storage capacity. In addition, evermore emphasis is put on processing the data to detect anomalous situations and to identify trends. This...conference paper 2013
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van der Veen, J.S. (author), van der Waaij, B.D. (author), Vonder, M.R. (author), de Jonge, M. (author), Lazovik, E. (author), Meijer, R.J. (author)Sensors have been used for many years to gather information about their environment. The number of sensors connected to the internet is increasing, which has led to a growing demand of data transport and storage capacity. In addition, evermore emphasis is put on processing the data to detect anomalous situations and to identify trends. This...conference paper 2013
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van der Kloet, F.M. (author), Tempels, F.W.A. (author), Ismail, N. (author), van der Heijden, R. (author), Kasper, P.T. (author), Rojas-Cherto, M. (author), van Doorn, R. (author), Spijksma, G. (author), Koek, M. (author), van der Greef, J. (author), Mäkinen, V.P. (author), Forsblom, C. (author), Holthöfer, H. (author), Groop, P.H. (author), Reijmers, T.H. (author), Hankemeier, T. (author)Diabetic kidney disease (DKD) is a devastating complication that affects an estimated third of patients with type 1 diabetes mellitus (DM). There is no cure once the disease is diagnosed, but early treatment at a sub-clinical stage can prevent or at least halt the progression. DKD is clinically diagnosed as abnormally high urinary albumin...article 2012
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Wortelboer, H.M. (author), Bijlsma, S. (author), Rubingh, C.M. (author), Meijerink, J. (author), Witkamp, R.F. (author)It is well established that dietary intake of n-3 fatty acids is associated with anti-inflammatory effects, and this has been linked to modulation of the oxylipin and endocannabinoid metabolomes. However, the amount of data on specific tissue effects is limited, and it is not known how inflammation affects this relation. In the present study we...article 2012
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Thissen, U. (author), Coulier, L. (author), Overkamp, K.M. (author), Jetten, J. (author), van de Werff, B.J.C. (author), van de Ven, T. (author), van der Werf, M.J. (author)In agricultural and food products, typical quality parameters are sensory properties, shelf-life, safety, health, nutritional value, crop yield per area and disease resistance. It is known that these parameters are importantly determined by the metabolites in the crops and food products. Metabolomics is the state-of-the-art routine technique...article 2011
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Hogervorst, M.A. (author), Schwering, P.B.W. (author)Electro-Optical (EO) imaging sensors are widely used for a range of tasks, e.g. for Target Acquisition (TA: detection, recognition and identification of (military) relevant objects) or visual search. These tasks can be performed by a human observer, by an algorithm (Automatic Target Recognition) or by both (Aided Target Recognition). In the past...bookPart 2011
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Vink, S.R. (author), Mikkers, J. (author), Bouwman, T. (author), Marquart, H. (author), Kroese, E.D. (author), TNO Kwaliteit van Leven (author)REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in substances to be registered under REACH....article 2010
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Muller, T. (author), Nowak, A. (author), Wiedensohler, A. (author), Sheridan, P. (author), Laborde, M. (author), Covert, D.S. (author), Marinoni, A. (author), Imre, K. (author), Henzing, B. (author), Roger, J.C. (author), Dos Santos, S.M. (author), Wilhelm, R. (author), Wang, Y.Q. (author), de Leeuw, G. (author), TNO Bouw en Ondergrond (author)Integrating nephelometers are widely used for monitoring and research applications related to air pollution and climate. Several commercial versions of the instrument are available and are in wide use in the community. This article reports on results from a calibration and intercomparison workshop where several units of the three most widely...article 2009
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Smilde, A.K. (author), Kiers, H.A.L. (author), Bijlsma, S. (author), Rubingh, C.M. (author), van Erk, M.J. (author), TNO Kwaliteit van Leven (author)Motivation: Modern functional genomics generates high-dimensional datasets. It is often convenient to have a single simple number characterizing the relationship between pairs of such high-dimensional datasets in a comprehensive way. Matrix correlations are such numbers and are appealing since they can be interpreted in the same way as Pearson's...article 2009
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Hockley, S.L. (author), Mathijs, K. (author), Staal, Y.C.M. (author), Brewer, D. (author), Giddings, I. (author), van Delft, J.H.M. (author), Phillips, D.H. (author), TNO Kwaliteit van Leven (author)Microarray technology is being used increasingly to study gene expression of biological systems on a large scale. Both interlaboratory and interplatform differences are known to contribute to variability in microarray data. In this study we have investigated data from different platforms and laboratories on the transcriptomic profile of HepG2...article 2009
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TNO Kwaliteit van Leven (author), van Schalkwijk, D.B. (author), de Graaf, A.A. (author), van Ommen, B. (author), van Bochove, K. (author), Rensen, P.C.N. (author), Havekes, L.M. (author), van de Pas, N.C.A. (author), Hoefsloot, H.C.J. (author), van der Greef, J. (author), Freidig, A.P. (author)Increased plasma cholesterol is a known risk factor for cardiovascular disease. Lipoprotein particles transport both cholesterol and triglycerides through the blood. It is thought that the size distribution of these particles codetermines cardiovascular disease risk. New types of measurements can determine the concentration of many lipoprotein...article 2009
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- Amelink-Verburg, M.P. (author), Buitendijk, S.E. (author), TNO Kwaliteit van Leven (author) article 2008
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Denby, B. (author), Schaap, M. (author), Segers, A. (author), Builtjes, P. (author), Horálek, J. (author), TNO Bouw en Ondergrond (author)Two different data assimilation techniques have been applied to assess exceedances of the daily and annual mean limit values for PM10 on the regional scale in Europe. The two methods include a statistical interpolation method (SI), based on residual kriging after linear regression of the model, and Ensemble Kalman filtering (EnKF). Both methods...article 2008
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van Leeuwen, D.M. (author), Pedersen, M. (author), Hendriksen, P.J.M. (author), Boorsma, A. (author), van Herwijnen, M.H.M. (author), Gottschalk, R.W.H. (author), Kirsch-Volders, M. (author), Knudsen, L.E. (author), Šrám, R.J. (author), Bajak, E. (author), van Delft, J.H.M. (author), Kleinjans, J.C.S. (author), TNO Kwaliteit van Leven (author)Differences in biological responses to exposure to hazardous airborne substances between children and adults have been reported, suggesting children to be more susceptible. Aim of this study was to improve our understanding of differences in susceptibility in cancer risk associated with air pollution by comparing genome-wide gene expression...article 2008
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Meijster, T. (author), Tielemans, E. (author), Schinkel, J. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Objectives: To effectively decrease occupational exposure to flour dust and related allergens, detailed information on exposure determinants and effectiveness of control measures is essential. In this paper, we use personal real-time exposure measurements to get more insight into the relationship between specific work characteristics, including...article 2008
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Spaan, S. (author), Schinkel, J. (author), Wouters, I.M. (author), Preller, L. (author), Tielemans, E. (author), Nij, E.T. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Objectives: Workers in many industries are exposed to endotoxins, which may cause adverse health effects. In exposure assessment, information about exposure variability is essential. However, variability in exposure has rarely been investigated for biological agents and more specifically for endotoxin. Therefore, variance components and...article 2008
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Mohangoo, A.D. (author), Buitendijk, S.E. (author), Hukkelhouen, C.W.P.M. (author), Ravelli, A.C.J. (author), Rijninks-van Driel, G.C. (author), Tamminga, P. (author), Nijhuis, J.G. (author)Objective. Comparison of perinatal mortality in the Netherlands with that in other European countries (Peristat-II), and with data collected 5 years previously (Peristat-I). Design. Descriptive study. Method. Indicators of perinatal mortality which were developed for Peristat-I were used again in Peristat-II. Data on perinatal mortality in 2004...article 2008
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TNO Kwaliteit van Leven (author), Joling, C.I. (author), Blatter, B.M. (author), Ybema, J.F. (author), Bongers, P.M. (author)Objectives. This study investigated whether work dedication and job resources are longitudinally related to work-related musculoskeletal disorders and whether job resources buffer the impact of job demands on these disorders? Methods. Data were used from a longitudinal three-phase study (2004, 2005, 2006) on health at work among a sample of...article 2008
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TNO Kwaliteit van Leven (author), Hageman, J.A. (author), van den Berg, R.A. (author), Westerhuis, J.A. (author), van der Werf, M.J. (author), Smilde, A.K. (author)Metabolomics and other omics tools are generally characterized by large data sets with many variables obtained under different environmental conditions. Clustering methods and more specifically two-mode clustering methods are excellent tools for analyzing this type of data. Two-mode clustering methods allow for analysis of the behavior of...article 2008