Searched for: subject:"Data%5C+Interpretation%2C%5C+Statistical"
(1 - 20 of 33)

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van Buuren, S. (author), Ooms, J.C.L. (author), TNO Kwaliteit van Leven (author)
This paper presents a method for calculating stage line diagrams, a novel type of reference diagram useful for tracking developmental processes over time. Potential fields of applications include: dentistry (tooth eruption), oncology (tumor grading, cancer staging), virology (HIV infection and disease staging), psychology (stages of cognitive...
article 2009
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Rodenburg, W. (author), Heidema, A.G. (author), Boer, J.M.A. (author), Bovee-Oudenhoven, I.M.J. (author), Feskens, E.J.M. (author), Mariman, E.C.M. (author), Keijer, J. (author), TNO Kwaliteit van Leven (author)
In whole genome microarray studies major gene expression changes are easily identified, but it is a challenge to capture small, but biologically important, changes. Pathway-based programs can capture small effects but may have the disadvantage of being restricted to functionally annotated genes. A structured approach toward the identification of...
article 2008
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Stierum, R. (author), Conesa, A. (author), Heijne, W. (author), Ommen, B.v. (author), Junker, K. (author), Scott, M.P. (author), Price, R.J. (author), Meredith, C. (author), Lake, B.G. (author), Groten, J. (author), TNO Kwaliteit van Leven (author), KvL (author)
Transcriptomics was performed to gain insight into mechanisms of food additives butylated hydroxytoluene (BHT), curcumin (CC), propyl gallate (PG), and thiabendazole (TB), additives for which interactions in the liver can not be excluded. Additives were administered in diets for 28 days to Sprague-Dawley rats and cDNA microarray experiments were...
article 2008
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Mons, M.N. (author), van der Wielen, J.M.L. (author), Blokker, E.J.M. (author), Sinclair, M.I. (author), Hulshof, K.F.A.M. (author), Dangendorf, F. (author), Hunter, P.R. (author), Medema, G.J. (author), TNO Kwaliteit van Leven (author)
The volume of cold tap water consumed is an essential element in quantitative microbial risk assessment. This paper presents a review of tap water consumption studies. Study designs were evaluated and statistical distributions were fitted to water consumption data from The Netherlands, Great Britain, Germany and Australia. We conclude that the...
article 2007
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van Buuren, S. (author), TNO Kwaliteit van Leven (author)
The goal of multiple imputation is to provide valid inferences for statistical estimates from incomplete data. To achieve that goal, imputed values should preserve the structure in the data, as well as the uncertainty about this structure, and include any knowledge about the process that generated the missing data. Two approaches for imputing...
article 2007
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van de Wiele, T.R. (author), Oomen, A.G. (author), Wragg, J. (author), Cave, M. (author), Minekus, M. (author), Hack, A. (author), Cornelis, C. (author), Rompelberg, C.J.M. (author), de Zwart, L.L. (author), Klinck, B. (author), van Wijnen, J. (author), Verstraete, W. (author), Sips, A.J.A.M. (author), TNO Kwaliteit van Leven (author)
This paper presents a multi-laboratory comparison study of in vitro models assessing bioaccessibility of soil-bound lead in the human gastrointestinal tract under simulated fasted and fed conditions. Oral bioavailability data from a previous human in vivo study on the same soil served as a reference point. In general, the bioaccessible lead...
article 2007
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Nueda, M.J. (author), Conesa, A. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Smilde, A.K. (author), Talón, M. (author), Ferrer, A. (author), TNO Kwaliteit van Leven (author)
Motivation: Designed microarray experiments are used to investigate the effects that controlled experimental factors have on gene expression and learn about the transcriptional responses associated with external variables. In these datasets, signals of interest coexist with varying sources of unwanted noise in a framework of (co)relation among...
article 2007
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Heymans, M.W. (author), van Buuren, S. (author), Knol, D.L. (author), van Mechelen, W. (author), de Vet, H.C.W. (author), TNO Kwaliteit van Leven (author)
Background. Missing data is a challenging problem in many prognostic studies. Multiple imputation (MI) accounts for imputation uncertainty that allows for adequate statistical testing. We developed and tested a methodology combining MI with bootstrapping techniques for studying prognostic variable selection. Method. In our prospective cohort...
article 2007
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Molag, M.L. (author), de Vries, J.H.M. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), van den Brandt, P.A. (author), Jansen, M.C.J.F. (author), van Staveren, W.A. (author), van 't Veer, P. (author), TNO Kwaliteit van Leven (author)
The authors investigated the role of food frequency questionnaire (FFQ) design, including length, use of portion-size questions, and FFQ origin, in ranking subjects according to their nutrient intake. They also studied the ability of the FFQ to detect differences in energy intake between subgroups and to assess energy and protein intake. In a...
article 2007
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Freidig, A.P. (author), Dekkers, S. (author), Verwei, M. (author), Zvinavashe, E. (author), Bessems, J.G.M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
Future EU legislations enforce a fast hazard and risk assessment of thousands of existing chemicals. If conducted by means of present data requirements, this assessment will use a huge number of test animals and will be neither cost nor time effective. The purpose of the current research was to develop methods to increase the acceptability of in...
article 2007
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Vis, D.J. (author), Westerhuis, J.A. (author), Smilde, A.K. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
Background: Innovative extensions of (M) ANOVA gain common ground for the analysis of designed metabolomics experiments. ASCA is such a multivariate analysis method; it has successfully estimated effects in megavariate metabolomics data from biological experiments. However, rigorous statistical validation of megavariate effects is still...
article 2007
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Kienhuis, A.S. (author), Wortelboer, H.M. (author), Maas, W.J. (author), van Herwijnen, M. (author), Kleinjans, J.C.S. (author), van Delft, J.H.M. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)
A rapid decline of cytochrome P450 (CYP450) enzyme activities remains a drawback of rat hepatocyte-based in vitro cultures. Consequently, judgment of the toxic potential of compounds that need bioactivation by CYP450s may not be adequate using this model. In the present study, an improved hepatocyte-based in vitro system was developed with...
article 2007
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Borghi, E. (author), de Onis, M. (author), Garza, C. (author), van den Broeck, J. (author), Frongillo, E.A. (author), Grummer-Strawn, L. (author), van Buuren, S. (author), Pan, H. (author), Molinari, L. (author), Martorell, R. (author), Onyango, A.W. (author), Martines, J.C. (author), Pinol, A. (author), Siyam, A. (author), Victoria, C.G. (author), Bhan, M.K. (author), Araújo, C.L. (author), Lartey, A. (author), Owusu, W.B. (author), Bhandari, N. (author), Norum, K.R. (author), Bjoerneboe, G.-E.Aa. (author), Mohamed, A.J. (author), Dewey, K.G. (author), Belbase, K. (author), Chumlea, C. (author), Cole, T. (author), Shrimpton, R. (author), Albernaz, E. (author), Tomasi, E. (author), de Cássia Fossati da Silveira, R. (author), Nader, G. (author), Sagoe-Moses, I. (author), Gomez, V. (author), Sagoe-Moses, C. (author), Taneja, S. (author), Rongsen, T. (author), Chetia, J. (author), Sharma, P. (author), Bahl, R. (author), Baerug, A. (author), Tufte, E. (author), Alasfoor, D. (author), Prakash, N.S. (author), Mabry, R.M. (author), Al Rajab, H.J. (author), Helmi, S.A. (author), Nommsen-Rivers, L.A. (author), Cohen, R.J. (author), Heinig, M.J. (author), TNO Kwaliteit van Leven (author)
The World Health Organization (WHO), in collaboration with a number of research institutions worldwide, is developing new child growth standards. As part of a broad consultative process for selecting the best statistical methods, WHO convened a group of statisticians and child growth experts to review available methods, develop a strategy for...
article 2006
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Dekkers, S. (author), Telman, J. (author), Rennen, M.A.J. (author), Appel, M.J. (author), de Heer, C. (author), TNO Industrie en Techniek TNO Kwaliteit van Leven (author)
In this study, the within-animal variation in routinely studied continuous toxicological parameters was estimated from temporal fluctuations in individual healthy nonexposed animals. Assuming that these fluctuations are nonadverse, this within-animal variation may be indicative of the minimal magnitude of the critical effect size (CES). The CES...
article 2006
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Jacobusse, G. (author), van Buuren, S. (author), Verkerk, P.H. (author)
Measurement of development is often less precise than that of height and weight. Developmental scores are typically based on passing one or more developmental markers, but do not have interval scale so calculating differences between scores can be nonsensical. Age-specific standardized scores are sometimes used, but fail to have a common metric...
article 2006
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Goldbohm, R.A. (author), Tielemans, E.L.J.P. (author), Heederik, D. (author), Rubingh, C.M. (author), Dekkers, S. (author), Willems, M.I. (author), Dinant Kroese, E. (author), TNO Kwaliteit van Leven (author)
It is generally recognized that human, epidemiological data, if available, are preferred as the starting point for quantitative risk analysis above the use of data from animal studies. Although methods to obtain proper risk estimates from epidemiological data are available, several impediments prevent their widespread application. These...
article 2006
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Miedema, H.M.E. (author), Groothuis-Oudshoorn, C.G.M. (author), TNO Bouw en Ondergrond (author)
A method for modeling the relationship of polychotomous health ratings with predictors such as area characteristics, the distance to a source of environmental contamination, or exposure to environmental pollutants is presented. The model combines elements of grouped regression and multilevel analysis. The statistical model describes the entire...
article 2006
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Paulussen, T.G.W. (author), Hoekstra, F. (author), Lanting, C.I. (author), Buijs, G.B. (author), Hirasing, R.A. (author), TNO Preventie en Gezondheid (author)
This study examines the factors that influence parents' decisions to have their children vaccinated under the Dutch National Immunisation Programme. A computer questionnaire was sent to 500 parents in 1999 (the response rate was 98.2%). The intention to vaccinate was most strongly determined by attitudes. The belief that vaccination is safe and...
article 2006
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Bijlsma, S. (author), Bobeldijk, I. (author), Verheij, E.R. (author), Ramaker, R. (author), Kochhar, S. (author), Macdonald, I.A. (author), van Ommen, B. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)
A large metabolomics study was performed on 600 plasma samples taken at four time points before and after a single intake of a high fat test meal by obese and lean subjects. All samples were analyzed by a liquid chromatography-mass spectrometry (LC-MS) lipidomic method for metabolic profiling. A pragmatic approach combining several well...
article 2006
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Garosi, P. (author), de Filippo, C. (author), van Erk, M. (author), Rocca-Serra, P. (author), Sansone, S.A. (author), Elliott, R. (author), TNO Kwaliteit van Leven (author)
Microarrays represent a powerful tool for studies of diet-gene interactions. Their use is, however, associated with a number of technical challenges and potential pitfalls. The cost of microarrays continues to drop but is still comparatively high. This, coupled with the complex logistical issues associated with performing nutritional microarray...
article 2005
Searched for: subject:"Data%5C+Interpretation%2C%5C+Statistical"
(1 - 20 of 33)

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