Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr-/-.Leiden mice

Background: NAFLD progression, from steatosis to inflammation and fibrosis, results from an interplay of intra- and extrahepatic mechanisms. Disease drivers likely include signals from white adipose tissue (WAT) and gut. However, the temporal dynamics of disease development remain poorly understood. Methods: High-fat-diet (HFD)-fed Ldlr-/-...

Microphysiological Systems to Recapitulate the Gut–Kidney Axis

Chronic kidney disease (CKD) typically appears alongside other comorbidities, highlighting an underlying complex pathophysiology that is thought to be vastly modulated by the bidirectional gut–kidney crosstalk. By combining advances in tissue engineering, biofabrication, microfluidics, and biosensors, microphysiological systems (MPSs) have...

Quantum dot arrays in silicon and germanium

Electrons and holes confined in quantum dots define excellent building blocks for quantum emergence, simulation, and computation. Silicon and germanium are compatible with standard semiconductor manufacturing and contain stable isotopes with zero nuclear spin, thereby serving as excellent hosts for spins with long quantum coherence. Here, we...

X-ray imaging sensor arrays on foil using solution processed organic photodiodes and organic transistors

We demonstrate organic imaging sensor arrays fabricated on flexible plastic foil with the solution processing route for both photodiodes and thin film transistors. We used the photovoltaic P3HT:PCBM blend for fabricating the photodiodes using spin coating and pentacene as semiconductor material for the TFTs. Photodiodes fabricated with P3HT:PCBM...

Analysis of inverse crosstalk channel estimation using SNR feedback

Digital subscriber line (DSL) data rates for short loops are typically limited by crosstalk between adjacent lines rather than by background noise. Precoding can reduce crosstalk in the downstream from the access node to the customer premises equipment significantly if an accurate estimate of the inverse crosstalk channel is provided. Recently,...

High throughput defect detection with multiple parallel electron beams

A new concept for high throughput defect detection with multiple parallel electron beams is described. As many as 30 000 beams can be placed on a footprint of a in.2, each beam having its own microcolumn and detection system without cross-talk. Based on the International Technology Roadmap for Semiconductors requirements, some high level...

Visual comfort of binocular and 3D displays

Imperfections in binocular image pairs can cause serious viewing discomfort. For example, in stereo vision systems eye strain is caused by unintentional mismatches between the left and right eye images (stereo imperfections). Head-mounted displays can induce eye strain due to optical misalignments. We have experimentally determined the level of ...

Substrate noise generation in complex digital systems: Efficient modeling and simulation methodology and experimental verification

More and more system-on-chip designs require the integration of analog circuits on large digital chips and will therefore suffer from substrate noise coupling. To investigate the impact of substrate noise on analog circuits, information is needed about digital substrate noise generation. In this paper, a recently proposed simulation methodology...