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Lejeail, M. (author), Fischer, H.R. (author)Stimulated by the growing demand for more sustainable polymer systems, experiments were performed to develop completely recyclable epoxy-based thermoset composite materials involving the separation, recovery, and complete reuse of both components of the composite, the resin and the fibers. In this study, a possibility to design such composites...article 2021
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Guo, Y. (author), van Ravensteijn, B.G.P. (author), Kegel, W.K. (author)Dimple colloids with well-defined cavities were synthesized by a modified dispersion polymerization. The key step in the procedure is the delayed addition of crosslinkers into the reaction mixture. By systematically studying the effect of the delayed addition time and the concentration of the cross-linker on the resulting particle morphology, we...article 2019
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Sasaki, T. (author), Stoop, R. (author), Sakai, T. (author), Hess, A. (author), Deutzmann, R. (author), Schlötzer-Schrehardt, U. (author), Chu, M.L. (author), von der Mark, K. (author)The extracellular matrix protein fibulin-4 has been shown to be indispensable for elastic fiber assembly, but there is also evidence from human mutations that it is involved in controlling skeletal development and bone stability. Fibulin-4 mutations were identified in patients suffering from vascular abnormality and/or cutis laxa, and some of...article 2016
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Willems, N.M.B.K. (author), Langenbach, G.E.J. (author), Stoop, R. (author), den Toonder, J.M.J. (author), Mulder, L. (author), Zentner, A. (author), Everts, V. (author)The role of mature collagen cross-links, pentosidine (Pen) cross-links in particular, in the micromechanical properties of cancellous bone is unknown. The aim of this study was to examine nonenzymatic glycation effects on tissue stiffness of demineralized and non-demineralized cancellous bone. A total of 60 bone samples were derived from...article 2014
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Kerkhof, M.H. (author), Ruiz-Zapata, A.M. (author), Bril, H. (author), Bleeker, M.C.G. (author), Belien, J.A.M. (author), Stoop, R. (author), Helder, M.N. (author)Objective The objective of this study was to compare histological and biochemical features of the (normal) precervical anterior vaginal wall and the prolapsed anterior vaginal wall of women with pelvic organ prolapse (POP). These data were compared to tissue of the precervical anterior vaginal wall of age-matched controls without POP to identify...article 2014
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Munialo, C.D. (author), de Jongh, H.H.J. (author), Broersen, K. (author), van der Linden, E. (author), Martin, A.H. (author)Fibrillar and spherical aggregates were prepared from whey protein isolate (WPI). These aggregates were thiolated to a substantial degree to observe any impact on functionality. Sulfur-containing groups were introduced on these aggregates which could be converted to thiol groups by deblocking. Changes on a molecular and microstructural level...article 2013
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Havenaar, R. (author), de Jong, A. (author), Koenen, M.E. (author), van Bilsen, J. (author), Janssen, A.M. (author), Labij, E. (author), Westerbeek, H.J.M. (author)Aim of this study was to investigate the digestion of transglutaminase cross-linked caseinate (XLC) versus native caseinate (NC) in solution and in cheese spread under digestive conditions for adults and children mimicked in a gastrointestinal model. Samples were collected for gel electrophoresis and nitrogen analysis. The results showed no...article 2013
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Gunbas, I.D. (author), Wouters, M.E.L. (author), van Benthem, R.A.T.M. (author), Koning, C.E. (author), Noordover, B.A.J. (author)In this work, two series of PDMS-modified poly(styrene-alt-maleic anhydride)s (PSMA) were prepared by the partial imidization of their anhydride groups with mono-functional, amine-terminated polydimethyl siloxanes (PDMS-NH2) with two different molecular weights. Subsequently, surfactant-free artificial latexes were prepared and characterized and...article 2013
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Steeneken, P.A.M. (author), Woortman, A.J.J. (author), Oudhuis, A.A.C.M. (author), TNO Kwaliteit van Leven (author)The thickening functionality of four acetylated di-starch adipates with variations in starch source and amylose and adipate contents was evaluated in a simplified small-scale model sauce system at fourteen processing conditions with variations in temperature, shear, and pH. A processing stability factor for a given starch was defined as a...article 2011
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Willems, N.M.B.K. (author), Mulder, L. (author), Bank, R.A. (author), Grünheid, T. (author), den Toonder, J.M.J. (author), Zentner, A. (author), Langenbach, G.E.J. (author)Although bone-tissue stiffness is closely related to the degree to which bone has been mineralized, other determinants are yet to be identified. We, therefore, examined the extent to which the mineralization degree, collagen, and its cross-links are related to bone-tissue stiffness. A total of 50 cancellous and cortical bone samples were derived...article 2011
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Canadell, J. (author), Fischer, H.R. (author), de With, G. (author), van Benthem, R.A.T.M. (author), TNO Industrie en Techniek (author)This study describes the synthesis, the spectroscopic, and the thermal characterization of linear and crosslinked polymers as well as a number of corresponding model compounds, containing Diels-Alder adducts derived from furan and maleimide groups. The thermal reversibility (rDA, DA) of structurally varied model compounds, polymeric and network...article 2010
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TNO Kwaliteit van Leven (author), Tak, P.P. (author), van Kuijk, A.W.R. (author), de Groot, J. (author), Koeman, R.C. (author), Sakkee, N. (author), Baeten, D.L. (author), Gerlag, D.M. (author)Background: There is growing interest in soluble biomarkers that could be used on the group level for screening purposes in small proof of principle studies during early drug development. We investigated early changes in serum levels of several candidate biomarkers involved in cartilage and bone metabolism following the initiation of adalimumab...article 2010
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Rubbens, M.P. (author), Mol, A. (author), Boerboom, R.A. (author), Bank, R.A. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Industrie en Techniek TNO Kwaliteit van Leven (author)Tissue-engineered heart valves lack sufficient amounts of functionally organized structures and consequently do not meet in vivo mechanical demands. To optimize tissue architecture and hence improve mechanical properties, various in vitro mechanical conditioning protocols have been proposed, of which intermittent straining is most promising in...article 2009
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Rubbens, M.P. (author), Mol, A. (author), van Marion, M.H. (author), Hanemaaijer, R. (author), Bank, R.A. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Kwaliteit van Leven (author)Similar to native cardiovascular tissues, the mechanical properties of engineered cardiovascular constructs depend on the composition and quality of the extracellular matrix, which is a net result of matrix remodeling processes within the tissue. To improve tissue remodeling, and hence tissue mechanical properties, various mechanical...article 2009
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), Jansen, K.M.B. (author), Verhaar, J.A.N. (author), de Groot, J. (author), Vanosch, G.J.V.M. (author), TNO Kwaliteit van Leven (author)To understand cartilage degenerative diseases and improve repair procedures, we investigate the influence of glycosaminoglycans (GAGs) on cartilage matrix biochemistry and functionality. Bovine articular chondrocytes were cultured in alginate beads with(out) para-nitrophenyl-beta-d-xyloside (PNPX) to inhibit GAG incorporation into newly formed...article 2009
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), van der Linden, J.C. (author), Zuurmond, A.M. (author), Weinans, H. (author), Verhaar, J.A.N. (author), van Osch, G.J.V.M. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)Background: Damage to articular cartilage is one of the features of osteoarthritis (OA). Cartilage damage is characterised by a net loss of collagen and proteoglycans. The collagen network is considered highly important for cartilage function but little is known about processes that control composition and function of the cartilage collagen...article 2008
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Hoogendoorn, R. (author), Doulabi, B.Z. (author), Huang, C.L. (author), Wuisman, P.I. (author), Bank, R.A. (author), Helder, M.N. (author), TNO Kwaliteit van Leven (author)Study Design. Caprine lumbar intervertebral discs (IVD) were collected from previous studies and categorized as normal, mildly, or severely degenerated. The biochemical composition and the RNA profiles present in both the nucleus pulposus (NP) and the anulus fibrosus (AF) were analyzed. Objective. To determine the molecular changes occurring in...article 2008
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TNO Kwaliteit van Leven (author), Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), Zuurmond, A.M. (author), Bank, R.A. (author), Verhaar, J.A.N. (author), de Groot, J. (author), van Osch, G.J.V.M. (author)Transforming growth factor beta (TGFbeta) is often used in cartilage tissue engineering to increase matrix formation by cells with various phenotypes. However, adverse effects of TGFbeta, such as extensive cross-linking in cultured fibroblasts, have also been reported. Our goal was to study effects of TGFbeta on collagen cross-linking and...article 2008
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Balguid, A. (author), Rubbens, M.P. (author), Mol, A. (author), Bank, R.A. (author), Bogers, A.J.J.C. (author), van Kats, J.P. (author), de Mol, B.A.J.M. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Kwaliteit van Leven (author)A major challenge in tissue engineering of functional heart valves is to determine and mimic the dominant tissue structures that regulate heart valve function and in vivo survival. In native heart valves, the anisotropic matrix architecture assures sustained and adequate functioning under high-pressure conditions. Collagen, being the main load...article 2007
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de Mos, M. (author), van El, B. (author), de Groot, J. (author), Jahr, H. (author), van Schie, H.T.M. (author), van Arkel, E.R. (author), Tol, H. (author), Heijboer, R. (author), van Osch, G.J.V.M. (author), Verhaar, J.A.N. (author), TNO Kwaliteit van Leven (author)Background: Understanding biochemical and structural changes of the extracellular matrix in Achilles tendinosis might be important for developing mechanism-based therapies. Hypothesis: In Achilles tendinosis, changes occur in biochemical composition and collagen turnover rate. Study Design: Descriptive laboratory study. Methods: From 10 patients...article 2007