Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients

The pharmacokinetics of cisplatin was investigated in 13 patients receiving 18 courses of cisplatin alone or in combination with amifostine to investigate the influence of amifostine (WR 2721; Ethyol) on the pharmacokinetics of cisplatin. Cisplatin was administered as a 1-h i.v. infusion, whereas amifostine was given i.v. over 15 min just before...

Pharmacokinetics of carboplatin with and without amifostine in patients with solid tumors

We showed previously that amifostine (WR 2721; Ethyol), a protector against carboplatin-induced toxicities, changed the pharmacokinetics of carboplatin in tumor-bearing nude mice. In the present study, the influence of amifostine on the pharmacokinetics of carboplatin was studied in patients when carboplatin was given in combination with three...

Impact of a moderately energy-restricted diet on energy metabolism and body composition in non-obese men

Objective: Since little information is available on the capacity of the non-obese to adapt to a moderate decrease in energy intake, the effect of a 10-week moderately energy-restricted diet (ER) on energy expenditure and body composition was studied. Design: A controlled intervention study. After a weight-maintaining run-in period of 2 weeks,...

Variability in man of the levels of some indices of nutritional status over a 60-d period on a constant diet

The biological variability of the values of various biochemical indices used for the assessment of the nutritional status of man was investigated in 4 healthy male volunteers (mean age 23 years). They were given a constant diet for 60 d, with the nutrient intake at the level of the Dutch recommendations. Blood was collected twice a week and 24-h...

Urinary excretion of 3-methylhistidine and creatinine by healthy Dutch children during day and night. The influence of age and sex

The urinary excretion of 3-methylhistidine and creatinine and the urinary 3-methylhistidine to creatinine excretion ratio during day and night were investigated in a group of 103 healthy, normally fed Dutch children (52 boys and 51 girls) aged 2-17 years. The 3-methylhistidine to creatinine ratio of the night urine appeared to be significantly...

Catecholamine excretion, conscience function and aggressive behaviour

This report deals with a study carried out among 46 12-17 year old boys, of the relationship between: (1) the excretion of waste products of catecholamines (methyladrenaline and methylnoradrenaline) and creatinine, (2) aggressive behaviour in a laboratory setting, and (3) data obtained via a conscience function questionnaire. The hypothesis that...