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Phthalate and bisphenol exposure during pregnancy and offspring nonverbal IQ

van den Dries, M.A. (author), Guxens, M. (author), Spaan, S. (author), Ferguson, K.K. (author), Philips, E. (author), Santos, S. (author), Jaddoe, V.W.V. (author), Ghassabian, A. (author), Trasande, L. (author), Tiemeier, H. (author), Pronk, A. (author)

BACKGROUND: Prenatal exposures to phthalates and bisphenols are associated with impaired brain development in animals. However, epidemiological studies investigating the association between prenatal phthalate or bisphenol exposure and cognition have produced mixed findings and mostly had modest sample sizes and measured the exposure during the...

article 2020

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Systems approach for classifying the response to biological therapies in patients with rheumatoid arthritis in clinical practice

Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)

Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...

article 2018

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Self-Monitoring Kidney Function Post Transplantation: Reliability of Patient-Reported Data

van Lint, C.L. (author), Wang, W. (author), van Dijk, S. (author), Brinkman, W.P. (author), Rövekamp, T.J.M. (author), Neerincx, M.A. (author), Rabelink, T.J. (author), van der Boog, P.J.M. (author)

Background: The high frequency of outpatient visits after kidney transplantation is burdensome to both the recovering patient and health care capacity. Self-monitoring kidney function offers a promising strategy to reduce the number of these outpatient visits. Objective: The objective of this study was to investigate whether it is safe to rely...

article 2017

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Weight loss predictability by plasma metabolic signatures in adults with obesity and morbid obesity of the DiOGenes study

Stroeve, J.H.M. (author), Saccenti, E. (author), Bouwman, J. (author), Dane, A. (author), Strassburg, K. (author), Vervoort, J. (author), Hankemeier, T. (author), Astrup, A. (author), Smilde, A.K. (author), van Ommen, B. (author), Saris, W.H.M. (author)

Objective: Aim is to predict successful weight loss by metabolic signatures at baseline and to identify which differences in metabolic status may underlie variations in weight loss success. Methods: In DiOGenes, a randomized, controlled trial, weight loss was induced using a low calorie diet (800 kcal) for 8-weeks. Men (N5236) and women (N5431)...

article 2016

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Application of a point of care creatinine device for trend monitoring in kidney transplant patients: Fit for purpose?

van Lint, C.L. (author), van der Boog, P.J.M. (author), Romijn, F.P.H.T.M. (author), Schenk, P.W. (author), van Dijk, S. (author), Rövekamp, T.J.M. (author), Kessler, A. (author), Siekmann, L. (author), Rabelink, T.J. (author), Cobbaert, C.M. (author)

Background: The StatSensor® Xpress-i™, a point-of-care system for blood creatinine measurement, offers patients the possibility of self-monitoring creatinine. In this study, the analytical performance of the StatSensor® for both detecting current renal function and monitoring renal (dys)function in kidney transplant patients was examined....

article 2015

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Patient experiences with self-monitoring renal function after renal transplantation: results from a single-center prospective pilot study

van Lint, C.L. (author), van der Boog, P.J.M. (author), Wang, W. (author), Brinkman, W.P. (author), Rövekamp, T.J.M. (author), Neerincx, M.A. (author), Rabelink, T.J. (author), van Dijk, S. (author)

Background: After a kidney transplantation, patients have to visit the hospital often to monitor for early signs of graft rejection. Self-monitoring of creatinine in addition to blood pressure at home could alleviate the burden of frequent outpatient visits, but only if patients are willing to self-monitor and if they adhere to the self...

article 2015

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Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia

Wagner, A. (author), Cohen, N. (author), Kelder, T. (author), Amit, U. (author), Liebman, E. (author), Steinberg, D.M. (author), Radonjic, M. (author), Ruppin, E. (author)

High-throughput omics have proven invaluable in studying human disease, and yet day-to-day clinical practice still relies on physiological, non-omic markers. The metabolic syndrome, for example, is diagnosed and monitored by blood and urine indices such as blood cholesterol levels. Nevertheless, the association between the molecular and the...

article 2015

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Of monkeys and men: A metabolomic analysis of static and dynamic urinary metabolic phenotypes in two species

Saccenti, E. (author), Tenori, L. (author), Verbruggen, P. (author), Timmerman, M.E. (author), Bouwman, J. (author), van der Greef, J. (author), Luchinat, C. (author), Smilde, A.K. (author)

Background: Metabolomics has attracted the interest of the medical community for its potential in predicting early derangements from a healthy to a diseased metabolic phenotype. One key issue is the diversity observed in metabolic profiles of different healthy individuals, commonly attributed to the variation of intrinsic (such as (epi)genetic...

article 2014

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Human metabolomics: Strategies to understand biology

Ramautar, R. (author), Berger, R. (author), van der Greef, J. (author), Hankemeier, T. (author)

Metabolomics provides a direct functional read-out of the physiological status of an organism and is in principle ideally suited to describe someone's health status. Whereas only a limited number of small metabolites are used in the clinics, in inborn errors of metabolism an extensive repertoire of metabolites are used as biomarkers. We discuss...

article 2013

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Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival

Offersen, B.V. (author), Knap, M.M. (author), Horsman, M.R. (author), Verheijen, J. (author), Hanemaaijer, R. (author), Overgaard, J. (author), TNO Kwaliteit van Leven (author)

Introduction. Matrix metalloproteinase 9 (MMP-9) is an endopeptidase involved in various cellular processes, such as tumour development and metastatic spread. In biological samples, MMP-9 can occur as pro-MMP-9 and active MMP-9, or these factors complexed with the inhibitor TIMP-1. An assay, which can measure active and total MMP-9 in biological...

article 2010

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Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK)

Vos, P.A.J.M. (author), de Groot, J. (author), Huisman, A.M. (author), Oostveen, J.C.M. (author), Marijnissen, A.C.A. (author), Bijlsma, J.W.J. (author), van El, B. (author), Zuurmond, A.M. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)

Objectives: Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels, alternative approaches...

article 2010

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The Netherlands twin register biobank: A resource for genetic epidemiological studies

Willemsen, G. (author), de Geus, E.J.C. (author), Bartels, M. (author), van Beijsterveldt, C.E.M.T. (author), Brooks, A.I. (author), Estourgie-van Burk, G.F. (author), Fugman, D.A. (author), Hoekstra, C. (author), Hottenga, J.-J. (author), Kluft, K. (author), Meijer, P. (author), Montgomery, G.W. (author), Rizzu, P. (author), Sondervan, D. (author), Smit, A.B. (author), Spijker, S. (author), Suchiman, H.E.D. (author), Tischfield, J.A. (author), Lehner, T. (author), Slagboom, P.E. (author), Boomsma, D.I. (author), TNO Kwaliteit van Leven (author)

In 2004 the Netherlands Twin Register (NTR) started a large scale biological sample collection in twin families to create a resource for genetic studies on health, lifestyle and personality. Between January 2004 and July 2008, adult participants from NTR research projects were invited into the study. During a home visit between 7:00 and 10:00 am...

article 2010

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P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury

Huls, M. (author), Kramers, C. (author), Levtchenko, E.N. (author), Wilmer, M.J.G. (author), Dijkman, H.B.P.M. (author), Kluijtmans, L.A.J. (author), van der Hoorn, J.W.A. (author), Russel, F.G.M. (author), Masereeuw, R. (author), TNO Kwaliteit van Leven (author)

The multidrug resistance gene 1 product, P-glycoprotein (P-gp), is expressed in several excretory organs, including the apical membrane of proximal tubules. After inducing acute renal failure, P-gp expression is upregulated and this might be a protective function by pumping out toxicants and harmful products of oxidative stress. We characterized...

article 2007

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Urinary pentosidine does not predict cartilage loss among subjects with symptomatic knee OA: The BOKS Study

Hunter, D.J. (author), LaValley, M. (author), Li, J. (author), Zhang, Y. (author), Bauer, D. (author), Nevitt, M. (author), Guermazi, A. (author), de Groot, J. (author), Sakkee, N. (author), Gale, D. (author), Felson, D.T. (author), TNO Kwaliteit van Leven (author)

Objective: Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major changes in the extracellular matrix of cartilage is the age-related accumulation of advanced glycation end products (AGEs). Pentosidine, an AGE crosslink, is one of the few characterized AGEs and is considered...

article 2007

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Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation

Keijzer-Veen, M.G. (author), Schrevel, M. (author), Finken, M.J.J. (author), Dekker, F.W. (author), Nauta, J. (author), Hille, E.T.M. (author), Frölich, M. (author), van der Heijden, B.J. (author), TNO Kwaliteit van Leven (author)

This prospective follow-up study of 422 19-yr-old subjects born very preterm in The Netherlands was performed to determine whether intrauterine growth retardation (IUGR) predisposes to abnormal GFR and microalbuminuria in adolescents. GFR (ml/min per 1.73 m2) was estimated using the Cockcroft-Gault equation, and albumin-creatinine ratio (mg/mmol...

article 2005

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Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis

Heijne, W.H.M. (author), Lamers, R.J.A.N. (author), van Bladeren, P.J. (author), Groten, J.P. (author), van Nesselrooij, J.H.J. (author), van Ommen, B. (author), TNO Kwaliteit van Leven (author)

This study investigated whether integrated analysis of transcriptomics and metabolomics data increased the sensitivity of detection and provided new insight in the mechanisms of hepatotoxicity. Metabolite levels in plasma or urine were analyzed in relation to changes in hepatic gene expression in rats that received bromobenzene to induce acute...

article 2005

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Markers for Type II Collagen Breakdown Predict the Effect of Disease-Modifying Treatment on Long-Term Radiographic Progression in Patients with Rheumatoid Arthritis

TNO Preventie en Gezondheid (author), Landewé, R. (author), Geusens, P. (author), Boers, M. (author), van der Heijde, D. (author), Lems, W. (author), te Koppele, J. (author), van der Linden, S. (author), Garnero, P. (author)

Objective. To investigate in a randomized clinical trial setting with an aggressive combination-therapy arm and a mild-monotherapy arm, whether therapy-induced changes in urinary C-terminal crosslinking telopeptide of type I collagen (CTX-I) and type II collagen (CTX-II) predict 5-year radiographic progression in patients with rheumatoid...

article 2004

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Enhanced urinary gelatinase activities (matrix metalloproteinases 2 and 9) are associated with early-stage bladder carcinoma: A comparison with clinically used tumor markers

Sier, C.F.M. (author), Casetta, G. (author), Verheijen, J.H. (author), Tizzani, A. (author), Agape, V. (author), Kos, J. (author), Blasi, F. (author), Hanemaaijer, R. (author), Gaubius Instituut TNO (author)

Matrix metalloproteinases (MMPs) are involved in tumor growth and metastasis, promoting the migration and invasion of cells. In this study, the amount of MMP-2 and MMP-9 activity was measured in urine from superficial bladder carcinoma patients (pTa, pT1) to evaluate their possible diagnostic value. The active and total amount of MMP-2 and MMP-9...

article 2000

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Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule I, but not with C-reactive protein in type 2 diabetic and non-diabetic subjects - The Hoorn Study

Becker, A. (author), van Hinsbergh, V.W.M. (author), Kostense, P.J. (author), Jager, A. (author), Dekker, J.M. (author), Nijpels, G. (author), Heine, R.J. (author), Bouter, L.M. (author), Stehouwer, C.D.A. (author), TNO Preventie en Gezondheid (author)

Background: Hyperhomocysteinaemia may constitute an independent risk factor for cardiovascular disease, but it is still unclear by which pathophysiological mechanisms homocysteine (tHcy) may promote atherothrombosis. The aim of this study was firstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of...

article 2000

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Evaluation of a subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonic acid oil derived from Mortierella alpina in rats

Hempenius, R.A. (author), Lina, B.A.R. (author), Haggitt, R.C. (author)

Arachidonic acid oil (ARA-oil) derived from the fungus Mortierella alpina for use in infant nutrition was tested in a subchronic (13-week) oral toxicity study in rats, preceded by an in utero exposure phase. The ARA-oil was administered as admixture to the rodent diet at dose levels of 3000 ppm, 15,000 ppm and 75,000 ppm. An additional high-dose...

article 2000