Economic Evaluation of Different Screening Strategies for Severe Combined Immunodeficiency Based on Real-Life Data

Although several countries have adopted severe combined immunodeficiency (SCID) into their newborn screening (NBS) program, other countries are still in the decision process of adding this disorder in their program and finding the appropriate screening strategy. This decision may be influenced by the cost(-effectiveness) of these screening...

Net zero-emission pathways reduce the physical and economic risks of climate change

Mitigation pathways exploring end-of-century temperature targets often entail temperature overshoot. Little is known about the additional climate risks generated by overshooting temperature. Here we assessed the benefits of limiting overshoot. We computed the probabilistic impacts for different warming targets and overshoot levels on the basis...

A North Atlantic Treaty Organisation Framework for Life Cycle Costing

There is a long and documented history of both cost growth and estimating optimism within military system acquisition programmes. This is particularly the case for multinational programmes. As the nature of future acquisition programmes will be more multinational oriented, a common approach is required to generate realistic and consistent LCC...

Clinical effectiveness and cost-effectiveness of the use of the thyroxine/thyroxine-binding globulin ratio to detect congenital hypothyroidism of thyroidal and central origin in a neonatal screening program

Context. Since the introduction of screening for congenital hypothyroidism (CH) in 1974, the optimal laboratory strategy has been the subject of debate. Objective. To assess the clinical effectiveness and cost-effectiveness of various types of thyroxine (T4)-based strategies to screen for CH. Design, Setting, and Participants. In the Netherlands...

Costs associated with persistent allergic rhinitis are reduced by levocetirizine

Background: Allergic rhinitis was recently classified by the ARIA guidelines as persistent or intermittent. Levocetivizine was shown to improve symptoms and health-related quality of life of patients with persistent allergic rhinitis in the XPERT™ study, a 6-month randomized double blind placebo-controlled trial. Objective: To assess the total...

Improved "BOCR" analysis with the AHP/ANP

This paper shows that the usual multiplicative synthesis of alternative priorities for benefits, opportunities, costs and risks, obtained from separate Analytic Hierarchy or Network models, can be ambiguous. The ratio of benefit and opportunity priorities to cost and risk priorities can be misleading when assessing the profitability of a project...

Life cycle cost analysis of cathodic protection of concrete. A case study

As a case study, the cost of applying cathodic protection (CP) to the columns and beams supporting two bridges was compared to the cost of replacement (due to reinforcement corrosion). All costs during the service life of the CP system were considered: initial cost, annual checks, maintenance of anode systems and specialist supervision. It was...

The isolated blood-perfused pig ear: An inexpensive and animal-saving model for skin penetration studies

To overcome most of the disadvantages of current models to investigate percutaneous penetration of drugs or toxic substances, a model is proposed here based on the isolated pig ear, which is obtained at the slaughterhouse, and perfused with oxygenated blood from the same pig. To determine the viability of the preparations, we measured glucose...