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te Biesebeke, R. (author), Ruijter, G. (author), Rahardjo, Y.S.P. (author), Hoogschagen, M.J. (author), Heerikhuisen, M. (author), Levin, A. (author), van Driel, K.G.A. (author), Schutyser, M.A.I. (author), Dijksterhuis, J. (author), Zhu, Y. (author), Weber, F.J. (author), de Vos, W.M. (author), van den Hondel, K.A.M.J.J. (author), Rinzema, A. (author), Punt, P.J. (author)We report the progress of a multi-disciplinary research project on solid-state fermentation (SSF) of the filamentous fungus Aspergillus oryzae. The molecular and physiological aspects of the fungus in submerged fermentation (SmF) and SSF are compared and we observe a number of differences correlated with the different growth conditions. First,...article 2002
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Gómez-Aracena, J. (author), Martin-Moreno, J.M. (author), Riemersma, R.A. (author), Bode, P. (author), Gutiérrez-Bedmar, M. (author), Gorgojo, L. (author), Kark, J.D. (author), Garcia-Rodríguez, A. (author), Gomez-Gracia, E. (author), Kardinaal, A.F.M. (author), Aro, A. (author), van 't Veer, P. (author), Wedel, H. (author), Kok, F.J. (author), Fernández-Crehuet, J. (author)The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail scandium were 6.74 μg/kg in cases and 7.75 μg/kg in...article 2002
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Huebner, J.L. (author), Hanes, M.A. (author), Beekman, B. (author), TeKoppele, J.M. (author), Kraus, V.B. (author), Gaubius Instituut (author)Objective: To evaluate the interaction of bone and cartilage in knee osteoarthritis (OA) pathogenesis in two guinea-pig strains with appreciable differences in bone metabolism. Design: Two guinea-pig strains were evaluated for their susceptibilities to OA using semi-quantitative histological grading of knee joints and quantification of...article 2002
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Graafmans, W.C. (author), Richardus, J.H. (author), Borsboom, G.J.J.M. (author), Bakketeig, L. (author), Langhoff-Roos, J. (author), Bergsjø, P. (author), Macfarlane, A. (author), Verloove-Vanhorick, P. (author), Mackenbach, J. (author), Aelvoet, W. (author), Alderdice, F. (author), Amelink, M. (author), Bakoula, C. (author), Blondel, B. (author), Bødker, B. (author), Bolumar, F. (author), Davidson, L. (author), Gissler, M. (author), Hartikainen, A.L. (author), Holt, J. (author), Kaminski, M. (author), Leidinger, J. (author), Lekea, V. (author), Lindmark, G. (author), Masuy-Stroobant, G. (author), van der Pal, K. (author), Penney, G. (author), Da Purificação Araújo, M. (author), Rantakallio, P. (author), Rebagliato, M. (author), TNO Preventie en Gezondheid (author)Background. Previous studies have suggested that a population's entire birth weight distribution may be shifted towards higher or lower birth weights, and that optimal birth weight may be lower in populations with a lower average birth weight. We evaluated this hypothesis for seven western European countries. Methods. We obtained data on all...article 2002
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TNO Preventie en Gezondheid (author), Tolboom, T.C.A. (author), Pieterman, E. (author), van der Laan, W.H. (author), Toes, R.E.M. (author), Huidekoper, A.L. (author), Nelissen, R.G.H.H. (author), Breedveld, F.C. (author), Huizinga, T.W.J. (author)Background: Matrix metalloproteinases (MMPs) have a pivotal role in the destruction of cartilage in rheumatoid arthritis (RA), which is mediated by the fibroblast-like synoviocytes (FLS). Objective: To examine the in vitro invasiveness of synoviocytes obtained from inflamed joints of patients with arthritis in relation to the expression of MMP 1...article 2002