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Stuurman, B. (author), Meijster, T. (author), Heederik, D. (author), Doekes, G. (author), TNO Kwaliteit van Leven (author)Objectives: To obtain an overview of inhalable β(1→3)glucans levels in Dutch industrial bakeries and explore possible associations with reported respiratory health effects in bakery workers. Methods: β(1→3)glucan levels were analysed in 186 personal inhalable dust measurements obtained from a random population of bakery workers. Association...article 2008
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Stiggelbout, M. (author), Hopman-Rock, M. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)This study reports entry correlates and motivations of older adults participating in organized exercise programs in the Netherlands, as determined in a descriptive explorative study (N = 2,350, response rate 86%). Participants were community-dwelling older adults (50+ years) who enrolled and started in 10 different exercise programs. Entiy...article 2008
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Post, M.W.M. (author), de Witte, L.P. (author), Reichrath, E. (author), Verdonschot, M.M. (author), Wijlhuizen, G.J. (author), Perenboom, R.J.M. (author), TNO Kwaliteit van Leven (author)Objective: IMPACT-S is the screener part of the ICF Measure of Participation and ACTivities questionnaire. IMPACT-S consists of 33 items in 9 scales, reflecting the 9 activity and participation chapters of the International Classification of Functioning, Disability and Health (ICF). The reliability and validity of IMPACT-S as an independent...article 2008
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Berbée, J.F.P. (author), van der Hoogt, C.C. (author), de Haas, C.J.C. (author), van Kessel, K.P.M. (author), Dallinga-Thie, G.M. (author), Romijn, J.A. (author), Havekes, L.M. (author), van Leeuwen, H.J. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)Objective: We recently reported that apolipoprotein CI (apoCI) protects against the development of murine bacterial sepsis. We now examined the time course of plasma apoCI levels in survivors and non-survivors of severe sepsis. Design: Prospective study in patients meeting predefined criteria for severe sepsis. Setting: University hospital...article 2008
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- van de Laar, F. (author), van de Lisdonk, E. (author), Lucassen, P. (author), Stafleu, A. (author), Mulder, J. (author), van den Hoogen, H. (author), Rutten, G. (author), van Weel, C. (author), TNO Kwaliteit van Leven (author) article 2008
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TNO Kwaliteit van Leven (author), Joosten, M.M. (author), Beulens, J.W.J. (author), Kersten, S. (author), Hendriks, H.F.J. (author)Aims/hypothesis: To determine whether 6 weeks of daily, moderate alcohol consumption increases expression of the gene encoding adiponectin (ADIPOQ) and plasma levels of the protein, and improves insulin sensitivity in postmenopausal women. Methods: In a randomised, open-label, crossover trial conducted in the Netherlands, 36 apparently healthy...article 2008
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Nanni, S. (author), Melandri, G. (author), Hanemaaijer, R. (author), Cervi, V. (author), Tomasi, L. (author), Altimari, A. (author), van Lent, N. (author), Tricoci, P. (author), Bacchi, L. (author), Branzi, A. (author), TNO Kwaliteit van Leven (author)Matrix metalloproteinases (MMPs) are thought to participate in the pathogenesis of coronary artery disease (CAD), particularly in the occurrence of acute coronary syndrome (ACS). Little is known about human in vivo MMP regulation in CAD. The expression and regulation of MMPs and their tissue inhibitors (TIMPs) were evaluated in premature CAD....article 2007
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van der Greef, J. (author), Martin, S. (author), Juhasz, P. (author), Adourian, A. (author), Plasterer, T. (author), Verheij, E.R. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)Systems biology has developed in recent years from a technology-driven enterprise to a new strategic tool in Life Sciences, particularly for innovative drug discovery and drug development. Combining the ultimate in systems phenotyping with in-depth investigations of biomolecular mechanisms will enable a revolution in our understanding of disease...article 2007
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van Weel, V. (author), Seghers, L. (author), de Vries, M.R. (author), Kuiper, E.J. (author), Schlingemann, R.O. (author), Bajema, I.M. (author), Lindeman, J.H.N. (author), van Delis-Diemen, P.M. (author), van Hinsbergh, V.W.M. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)OBJECTIVE - Vascular endothelial growth factor (VEGF)-induced stromal cell-derived factor-1 (SDF-1) has been implicated in angiogenesis in ischemic tissues by recruitment of CXCR4-positive bone marrow-derived circulating cells with paracrine functions in preclinical models. Here, evidence for this is provided in patients with peripheral artery...article 2007
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Lammers, J.H.C.M. (author), Emmen, H.H. (author), Muijser, H. (author), Hoogendijk, E.M.G. (author), McKee, R.H. (author), Owen, D.E. (author), Kulig, B.M. (author), TNO Kwaliteit van Leven (author)To evaluate the neurobehavioral effects of hydrocarbon solvents and to establish a working model for extrapolating animal test data to humans, studies were conducted which involved inhalation exposure of rats and humans to white spirit (WS). The specific objectives of these studies were to evaluate the behavioral effects of exposure to WS in...article 2007
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Nueda, M.J. (author), Conesa, A. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Smilde, A.K. (author), Talón, M. (author), Ferrer, A. (author), TNO Kwaliteit van Leven (author)Motivation: Designed microarray experiments are used to investigate the effects that controlled experimental factors have on gene expression and learn about the transcriptional responses associated with external variables. In these datasets, signals of interest coexist with varying sources of unwanted noise in a framework of (co)relation among...article 2007
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Kuijt-Evers, L.F.M. (author), Bosch, T. (author), Huysmans, M.A. (author), de Looze, M.P. (author), Vink, P. (author), TNO Kwaliteit van Leven (author)In the current study, the relationship between objective measurements and subjective experienced comfort and discomfort in using handsaws was examined. Twelve carpenters evaluated five different handsaws. Objective measures of contact pressure (average pressure, pressure area and pressure-time (P-t) integral) in static and dynamic conditions,...article 2007
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Molag, M.L. (author), de Vries, J.H.M. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), van den Brandt, P.A. (author), Jansen, M.C.J.F. (author), van Staveren, W.A. (author), van 't Veer, P. (author), TNO Kwaliteit van Leven (author)The authors investigated the role of food frequency questionnaire (FFQ) design, including length, use of portion-size questions, and FFQ origin, in ranking subjects according to their nutrient intake. They also studied the ability of the FFQ to detect differences in energy intake between subgroups and to assess energy and protein intake. In a...article 2007
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Zafranskaya, M. (author), Oschmann, P. (author), Engel, R. (author), Weishaupt, A. (author), van Noort, J.M. (author), Jomaa, H. (author), Eberl, M. (author), TNO Kwaliteit van Leven (author)Therapy with interferon-β (IFN-β) has well-established clinical effects in multiple sclerosis (MS), albeit the immunomodulatory mechanisms are not fully understood. We assessed the prevalence and functional capacity of CD4+ and CD8+ T cells in healthy donors, and in untreated and IFN-β-treated MS patients, in response to myelin oligodendrocyte...article 2007
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Ravens-Sieberer, U. (author), Auquier, P. (author), Erhart, M. (author), Gosch, A. (author), Rajmil, L. (author), Bruil, J. (author), Power, M. (author), Duer, W. (author), Cloetta, B. (author), Czemy, L. (author), Mazur, J. (author), Czimbalmos, A. (author), Tountas, Y. (author), Hagquist, C. (author), Kilroe, J. (author), Fuerth, K. (author), Czerny, L. (author), Simeoni, M.C. (author), Robitail, S. (author), Nickel, J. (author), Kurth, B.-M. (author), von Rüden, U. (author), Dimitrakakis, C. (author), Aszman, A. (author), Flannery, E. (author), Detmar, S. (author), Veripps, E. (author), Mierzejeswka, E. (author), Berra, S. (author), Tebé, C. (author), Herdman, M. (author), Alonso, J. (author), Abel, T. (author), Bisegger, C. (author), Farley, C. (author), Atherton, C. (author), Phillips, K. (author), TNO Kwaliteit van Leven (author)Objective: To assess the construct and criterion validity of the KIDSCREEN-27 health-related quality of life (HRQoL) questionnaire, a shorter version of the KIDSCREEN-52. Methods: The five-dimensional KIDSCREEN-27 was tested in a sample of 22,827. For criterion validity the correlation with and the percentage explained variance of the scores of...article 2007
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van Loon, M. (author), Vautard, R. (author), Schaap, M. (author), Bergström, R. (author), Bessagnet, B. (author), Brandt, J. (author), Builtjes, P.J.H. (author), Christensen, J.H. (author), Cuvelier, C. (author), Graff, A. (author), Jonson, J.E. (author), Krol, M. (author), Langner, J. (author), Roberts, P. (author), Rouil, L. (author), Stern, R. (author), Tarrasón, L. (author), Thunis, P. (author), Vignati, E. (author), White, L. (author), Wind, P. (author), TNO Bouw en Ondergrond (author)Long-term ozone simulations from seven regional air quality models, the Unified EMEP model, LOTOS-EUROS, CHIMERE, RCG, MATCH, DEHM and TM5, are intercompared and compared to ozone measurements within the framework of the EuroDelta experiment, designed to assess air quality improvement at the European scale in response to emission reduction...article 2007
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Buist, H.E. (author), de Heer, C. (author), van Burgsteden, J.A. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)The in vitro dermal absorption kinetics of didecyldimethylammonium chloride (DDAC) was studied after single and multiple exposure. In addition, the influence of biocidal formulations on the absorption of DDAC was investigated. Following dermal exposure to DDAC in aqueous solution, less than 0.5% of the applied dose reached the receptor fluid...article 2007
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Guzik, P. (author), Piskorski, J. (author), Krauze, T. (author), Schneider, R. (author), Wesseling, K.H. (author), Wykrȩtowicz, A. (author), Wysocki, H. (author), TNO Biomedical Instrumentation (author)Aim: To analyze the correlation of the Poincaré plot descriptors of RR intervals with standard measures of heart rate variability (HRV) and spontaneous baroreflex sensitivity (BRS). A physiological model of changing respiratory rates from 6 to 15 breaths/min provided a wide range of RR intervals for analysis. Material and methods: Beat-to-beat...article 2007
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TNO Kwaliteit van Leven (author), Hawinkels, L.J.A.C. (author), Verspaget, H.W. (author), van Duijn, W. (author), van der Zon, J.M. (author), Zuidwijk, K. (author), Kubben, F.J.G.M. (author), Verheijen, J.H. (author), Hommes, D.W. (author), Lamers, C.B.H.W. (author), Sier, C.F.M. (author)Transforming growth factor-beta1 (TGF-beta1), a tumour suppressing as well as tumour-promoting cytokine, is stored as an extracellular matrix-bound latent complex. We examined TGF-beta1 activation and localisation of TGF-beta1 activity in gastric cancer. Gastric tumours showed increased stromal and epithelial total TGF-beta1 staining by...article 2007
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de Lange, M. (author), de Geus, E.J.C. (author), Kluft, C. (author), Meijer, P. (author), van Doornen, L.J.P. (author), Boomsma, D.I. (author), Snieder, H. (author), TNO Kwaliteit van Leven (author)Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in...article 2006