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van Bilsen, J.H.M. (author), van den Brink, W. (author), van den Hoek, A.M. (author), Dulos, R. (author), Caspers, M.P.M. (author), Kleeman, R. (author), Wopereis, S. (author), Verschuren, L. (author)Metabolic disorders, such as obesity and type 2 diabetes have a large impact on global health, especially in industrialized countries. Tissue-specific chronic low-grade inflammation is a key contributor to complications in metabolic disorders. To support therapeutic approaches to these complications, it is crucial to gain a deeper understanding...article 2021
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Nickel, S. (author), Schröder, W. (author), Schmalfuss, R. (author), Saathoff, M. (author), Harmens, H. (author), Mills, G. (author), Frontasyeva, M.V. (author), Barandovski, L. (author), Blum, O. (author), Carballeira, A. (author), de Temmerman, L. (author), Dunaev, A.M. (author), Ene, A. (author), Fagerli, H. (author), Godzik, B. (author), Ilyin, I. (author), Jonkers, S. (author), Jeran, Z. (author), Lazo, P. (author), Leblond, S. (author), Liiv, S. (author), Mankovska, B. (author), Núñez-Olivera, E. (author), Piispanen, J. (author), Poikolainen, J. (author), Popescu, I.V. (author), Qarri, F. (author), Santamaria, J.M. (author), Schaap, M. (author), Skudnik, M. (author), Špirić, Z. (author), Stafilov, T. (author), Steinnes, E. (author), Stihi, C. (author), Suchara, I. (author), Uggerud, H.T. (author), Zechmeister, H.G. (author)Background: This paper aims to investigate the correlations between the concentrations of nine heavy metals in moss and atmospheric deposition within ecological land classes covering Europe. Additionally, it is examined to what extent the statistical relations are affected by the land use around the moss sampling sites. Based on moss data...article 2018
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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...article 2018
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Coenen, P. (author), Kingma, I. (author), Boot, C.R.L. (author), Bongers, P.M. (author), van Dieën, J.H. (author)The trade-off between feasibility and accuracy of measurements of physical exposure at the workplace has often been discussed, but is unsufficiently understood. We therefore explored the effect of two low-back loading measurement tools with different accuracies on exposure estimates and their associations with low-back pain (LBP). Low-back...article 2015
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Morrison, M.C. (author), Kleemann, R. (author)Obesity is associated with a chronic low-grade inflammatory state that drives the -development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This metabolic inflammation is thought to originate in the adipose tissue, which becomes inflamed and...article 2015
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Bergh, L.I.V. (author), Ringstad, A.J. (author), Leka, S. (author), Zwetsloot, G.I.J.M. (author)Hydrocarbon leaks have a major accident potential in the oil and gas industry. Over the years the oil and gas industry in Norway has worked hard to find means to prevent hydrocarbon leaks and is today able to report significant progress. In this context, the exploration of accidents in light of human error linked to underlying factors related to...article 2014
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Wijtzes, A.I. (author), Kooijman, M.N. (author), Kiefte-de Jong, J.C. (author), de Vries, S.I. (author), Henrichs, J. (author), Jansen, W. (author), Jaddoe, V.W.V. (author), Hofman, A. (author), Moll, H.A. (author), Raat, H. (author)Objective: To describe and identify correlates of objectively measured physical activity and sedentary behavior in 2-year-old toddlers. Study design: A total of 347 children participating in a birth cohort study wore a unaxial ActiGraph accelerometer during 1 weekday and 1 weekend day. Information on potential correlates was assessed by parent...article 2013
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- van Dommelen, P. (author), Schönbeck, Y. (author), van Buuren, S. (author) article 2012
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van Delft, J.H.M. (author), Mathijs, K. (author), Staal, Y.C.M. (author), van Herwijnen, M.H.M. (author), Brauers, K.J.J. (author), Boorsma, A. (author), Kleinjans, J.C.S. (author), TNO Kwaliteit van Leven (author)Chemical carcinogens may cause a multitude of effects inside cells, thereby affecting transcript levels of genes by direct activation of transcription factors (TF) or indirectly through the formation of DNA damage. As the temporal profiles of these responses may be profoundly different, examining time-dependent changes may provide new insights...article 2010
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Offersen, B.V. (author), Knap, M.M. (author), Horsman, M.R. (author), Verheijen, J. (author), Hanemaaijer, R. (author), Overgaard, J. (author), TNO Kwaliteit van Leven (author)Introduction. Matrix metalloproteinase 9 (MMP-9) is an endopeptidase involved in various cellular processes, such as tumour development and metastatic spread. In biological samples, MMP-9 can occur as pro-MMP-9 and active MMP-9, or these factors complexed with the inhibitor TIMP-1. An assay, which can measure active and total MMP-9 in biological...article 2010
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TNO Kwaliteit van Leven (author), Tak, P.P. (author), van Kuijk, A.W.R. (author), de Groot, J. (author), Koeman, R.C. (author), Sakkee, N. (author), Baeten, D.L. (author), Gerlag, D.M. (author)Background: There is growing interest in soluble biomarkers that could be used on the group level for screening purposes in small proof of principle studies during early drug development. We investigated early changes in serum levels of several candidate biomarkers involved in cartilage and bone metabolism following the initiation of adalimumab...article 2010
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van Deemter, M. (author), Ponsioen, T.L. (author), Bank, R.A. (author), Snabel, J.M.M. (author), van der Worp, R.J. (author), Hooymans, J.M.M. (author), Los, L.I. (author), TNO Kwaliteit van Leven (author)The human vitreous body undergoes structural changes with aging. This can be followed by a posterior vitreous detachment, which can result in ocular pathology. As in many collagenous tissues, age-related changes in the vitreous could be caused by the formation of advanced glycation end products (AGEs). The goal of this study was to find out...article 2009
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van den Berg, R.A. (author), Rubingh, C.M. (author), Westerhuis, J.A. (author), van der Werf, M.J. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)In metabolomics research, it is often important to focus the data analysis to specific areas of interest within the metabolome. In this paper, we describe the application of consensus principal component analysis (CPCA) and canonical correlation analysis (CCA) as a means to explore the relation between metabolome data and (i) biochemically...article 2009
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Parker, A.L. (author), Waddington, S.N. (author), Buckley, S.M.K. (author), Custers, J. (author), Havenga, M.J.E. (author), van Rooijen, N. (author), Goudsmit, J. (author), McVey, J.H. (author), Nicklin, S.A. (author), Baker, A.H. (author), TNO Kwaliteit van Leven (author)The deployment of adenovirus serotype 5 (Ad5)-based vectors is hampered by preexisting immunity. When such vectors are delivered intravenously, hepatocyte transduction is mediated by the hexon-coagulation factor X (FX) interaction. Here, we demonstrate that human sera efficiently block FX-mediated cellular binding and transduction of Ad5-based...article 2009
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Plaisier, M. (author), Dennert, I. (author), Rost, E. (author), Koolwijk, P. (author), van Hinsbergh, V.W.M. (author), Helmerhorst, F.M. (author), TNO Kwaliteit van Leven (author)BACKGROUND : Decidual vascular development is important for implantation. This study analysed decidual vascular adaptation to implantation in correlation with miscarriage in decidual secretory endometrium (DSE), decidua parietalis (DP) and decidua basalis (DB) of miscarriage patients and matched controls. METHODS : Decidua was obtained during...article 2009
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Hockley, S.L. (author), Mathijs, K. (author), Staal, Y.C.M. (author), Brewer, D. (author), Giddings, I. (author), van Delft, J.H.M. (author), Phillips, D.H. (author), TNO Kwaliteit van Leven (author)Microarray technology is being used increasingly to study gene expression of biological systems on a large scale. Both interlaboratory and interplatform differences are known to contribute to variability in microarray data. In this study we have investigated data from different platforms and laboratories on the transcriptomic profile of HepG2...article 2009
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Wiefferink, C.H. (author), Detmar, S.B. (author), Coumans, B. (author), Vogels, T. (author), Paulussen, T.G.W. (author), TNO Kwaliteit van Leven (author)The aim of this study is to identify the social psychological determinants of the use of performance-enhancing drugs by gym users who practice bodybuilding, fitness, powerlifting or combat sports. In this questionnaire-based study, 144 respondents answered questions on their actual use and intention to use such drugs and also on their background...article 2008
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Toet, A. (author), Jansen, S.E.M. (author), Delleman, N.J. (author), TNO Defensie en Veiligheid (author), Nato (author)Field-of-view (FOV) restrictions are known to affect human behaviour and to degrade performance for a range of different tasks. However, the relationship between human locomotion performance in complex environments and FOV size is currently not fully known. This paper examined the effects of FOV restrictions on the performance of participants...article 2008
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Rijken, D.C. (author), Hoegee-de Nobel, E. (author), Jie, A.F.H. (author), Atsma, D.E. (author), Schalij, M.J. (author), Nieuwenhuizen, W. (author), TNO Kwaliteit van Leven (author)Background: The development of global tests for the fibrinolytic capacity in blood is hampered by the low base-line fibrinolytic activity in blood, by the involvement of both plasmatic components and blood cells in the fibrinolytic system and by the loss of fibrinolytic activity as a result of the action of plasminogen activator inhibitor-1 (PAI...article 2008
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Berbée, J.F.P. (author), Mooijaart, S.P. (author), de Craen, A.J.M. (author), Havekes, L.M. (author), van Heemst, D. (author), Rensen, P.C.N. (author), Westendorp, R.G.J. (author), TNO Kwaliteit van Leven (author)The high-density lipoprotein (HDL) constituent apolipoprotein CI (apoCI) protects mice against mortality in bacterial sepsis. We assessed whether high plasma apoCI levels protect against mortality from infection in humans. We determined plasma levels of apoCI, lipids, and C-reactive protein in 85-year-old participants of the prospective...article 2008