Increasing oxime efficacy by blood-brain barrier modulation

One of the shortcomings of current treatment of nerve agent poisoning is that oximes hardly penetrate the blood-brain barrier (BBB), whereas nerve agents easily do. Increasing the concentration of oximes in the brain, would therefore provide an attractive approach to improve medical countermeasures. An explanation for limited penetration might...

De betekenis van consulieachtige verschijnselen in de eerste twee levensjaren [mportance of convulsion-like signs during the first two years of life]

Objective. Assessment of the prevalence of convulsion-like symptoms in 1854 children of Dutch-speaking mothers of a population-based birth cohort. Method. At each child health clinic (CHC) visit mothers were asked whether they had noted any of the following signs: loss of consciousness, involuntary movements, eye rotation movements and apnoea,...

Long-term changes in glial fibrillary acidic protein and calcium levels in rat hippocampus after a single systemic dose of kainic acid

Chemicals/CAS: calcium, 7440-70-2; kainic acid, 487-79-6; Biological Markers; Calcium, 7440-70-2; Glial Fibrillary Acidic Protein; Kainic Acid, 487-79-6; Neurotoxins

Behavioral performance, brain histology, and EEG sequela after immediate combined atropine/diazepam treatment of soman-intoxicated rats

It is known that rats poisoned with near-lethal doses of pinacolyl methylphosphonofluoridate (soman) develop brain lesions, particularly when convulsions are induced. When rats were intoxicated with a LD50 of soman and treated immediately thereafter with a combination of low doses of atropine and diazepam (LOW AS/DZ treatment), large decrements...