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Borgdorff, H. (author), Verwijs, M.C. (author), Wit, F.W.N.M. (author), Tsivtsivadze, E. (author), Ndayisaba, G.F. (author), Verhelst, R. (author), Schuren, F.H. (author), van de Wijgert, J.H.H.M. (author)Background The observed association between Depo-Provera injectable use and increased HIV acquisition may be caused by hormone-induced increased susceptibility to other sexually transmitted infections (STIs) or changes in the cervicovaginal microbiota (VMB), accompanied by genital immune activation and/or mucosal remodeling. Methods Rwandan...article 2015
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Kluft, C. (author), Meijer, P. (author), LaGuardia, K.D. (author), Fisher, A.C. (author), TNO Kwaliteit van Leven (author)Purpose: The aim of this study was to compare effects of the transdermal contraceptive patch, a desogestrel/ethinyl estradiol (EE)-containing, monophasic combination oral contraceptive (COC) and a levonorgestrel/EE-containing, triphasic COC on hemostasis variables. Study Design: This was a randomized, open-label study of 104 young women who...article 2008
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Sitruk-Ware, R.L. (author), Menard, J. (author), Rad, M. (author), Burggraaf, J. (author), de Kam, M.L. (author), Tokay, B.A. (author), Sivin, I. (author), Kluft, C. (author), TNO Kwaliteit van Leven (author)Objective: We evaluated the effects of a new combined hormonal contraceptive vaginal ring (CVR) delivering the nonandrogenic progestin Nestorone® (NES) and ethinyl estradiol (EE) on several key estrogen-sensitive hepatic proteins that may be markers for the risk of arterial or venous disease events and on blood pressure (BP). Because the...article 2007
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Loerbroks, A. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Objective: To examine the association between alcohol consumption, cigarette smoking, and endometrial cancer. Methods: In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women. Follow-up for cancer was established by record linkage to the...article 2007
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Rad, M. (author), Kluft, C. (author), Ménard, J. (author), Burggraaf, J. (author), de Kam, M.L. (author), Meijer, P. (author), Sivin, I. (author), Sitruk-Ware, R.L. (author), TNO Kwaliteit van Leven (author)Objective: This study aimed to compare the effects on hemostasis variables of a contraceptive vaginal ring with those of an oral contraceptive. Study design: Twenty-three and 22 healthy premenopausal women were randomized to the contraceptive vaginal ring (150 μg Nestorone and 15 μg ethinyl estradiol) or Stediril 30 during 3 cycles. Analysis of...article 2006
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Kluft, C. (author), Endrikat, J. (author), Mulder, S.M. (author), Gerlinger, C. (author), Heithecker, R. (author), TNO Kwaliteit van Leven (author)Purpose: In this open-label, randomized study, we assessed the effects on hemostasis of two combined oral contraceptives containing drospirenone (DRSP) as progestogen component. Methods: Three milligrams of DRSP, a progestogen with antimineralocorticoid activity, was combined with either 30 or 20 μg ethinyl estradiol (EE) (DRSP/30EE; DRSP/20EE)...article 2006
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TNO Kwaliteit van Leven TNO Voeding (author), Genkinger, J.M. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Buring, J.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Harnack, L. (author), Hankinson, S.E. (author), Larsson, S.C. (author), Leitzmann, M. (author), McCullough, M.L. (author), Marshall, J. (author), Miller, A.B. (author), Rodriguez, C. (author), Rohan, T.E. (author), Schatzkin, A. (author), Schouten, L.J. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author)Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating...article 2006
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TNO Kwaliteit van Leven TNO Preventie en Gezondheid (author), Maat, M.P.M.de (author), Bladbjerg, E.M. (author), Kluft, C. (author), Winkler, U.H. (author), Rekers, H. (author), Skouby, S.O. (author), Jespersen, J. (author)Background: Administration of oral contraceptives (OCs) has profound effects on the plasma levels of haemostasis and inflammation variables, resulting in an increased thrombosis risk. Individuals show large differences in the response of these variables to OCs. Polymorphism in the estrogen receptor-1 (ER1) gene may explain part of this inter...article 2006
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Gaubius Instituut TNO (author), Skouby, S.O. (author), Jespersen, J. (author), Kluft, C. (author), Lowe, G.D.O. (author), Norris, L. (author), Stevenson, J. (author), Samsioe, G. (author)Oral contraceptives (OCs) have a wide spread use and hormonal replacement therapy (HRT) a clear place in the treatment of climacteric symptoms although its long-term use is under continued evaluation. Unbalanced information from the mass media has presented a negative attitude towards the use of female hormones in relation to cardiovascular...article 2003
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Kluft, C. (author), de Maat, M.P.M. (author), Heinemann, L.A.J. (author), Spannagl, M. (author), Schramm, W. (author), Gaubius instituut TNO (author)Combined oral contraceptives show clear differences in effect on the tissue factor-initiated coagulation test of activated protein C resistance, which is dependent on the presence and dosage of levonorgestrel. Multiphasic levonorgestrol oral contraceptives differ from monophasic contraceptives and resemble third-generation contraceptives. The...article 1999
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van Hooff, M.H.A. (author), Hirasing, R.A. (author), Kaptein, M.B.M. (author), Koppenaal, C. (author), Voorhorst, F.J. (author), Schoemaker, J. (author), TNO Preventie en Gezondheid (author)Background. Oral contraceptives are prescribed as contraception but also as therapy for menstrual cycle disturbances and acne. We studied the prevalence of oral contraceptive (OC) use and the indications to start OC use among adolescents. Methods. A cohort consisting of ninth grade secondary school girls (mean age 15.3 ± 0.6 (s.d.) years)...article 1998
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Massé, P.G. (author), van den Berg, H. (author), Livingstone, M.M. (author), Duguay, C. (author), Beaulieu, G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)The present study was aimed to assess the psychological status of young healthy women after the administration of a triphasic contraceptive steroid preparation for six complete menstrual cycles. Subjects had never used oral contraceptives (OC) and had neither a familial history of depression nor psychological disturbances. OC-induced...article 1998
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Mannaerts, B.M.J.L. (author), Geurts, T.B.P. (author), Odink, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The objective of this study was to compare the bioavailability of s.c. and i.m. administration of human chorionic gonadotrophin (HCG; Pregnyl®). In a randomized, single centre, three-way cross-over study, 18 healthy pituitary-suppressed volunteers were assigned to single HCG injections of 5000 and 10000 IU i.m. and 10000 IU s.c. Rate (C(max), t...article 1998
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Kluft, C. (author), Lansink, M. (author), Gaubius Instituut TNO (author)Combined oral contraceptives (COCs) have effects on a large number of haemostasis variables. We have summarised literature data on effects of COCs containing 30-35 μg ethinyl estradiol for the third generation of progestogens (PGs): desogestrel, gestodene and norgestimate. It is concluded that about 15 variables show a shift in distribution of...article 1997
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Massé, P.G. (author), van den Berg, H. (author), Duguay, C. (author), Beaulieu, G. (author), Simard, J.M. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The objectives of the study were to follow-up six artificial menstrual cycles induced by Triphasil® in order to determine: 1) the time of apparition of B6 metabolic side-effects, in the eventuality they occur, and 2) the existence or non-existence of a normalization process and if so, when it is initiated. The choice of this triphasic OC...article 1996
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Hartmann, D. (author), Güzelhan, C. (author), Zuiderwijk, P.B.M. (author), Odink, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objectives: Orlistat, a potent and selective inhibitor of gastrointestinal lipases, is designed for the treatment of obesity. A double-blind, randomised, placebo-controlled, 2-way crossover study investigated the possible influence of orlistat on the ovulation-suppressing action of combination oral contraceptives (OC). Methods: After an 8-day...article 1996
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Hennis, B.C. (author), Boomsma, D.I. (author), Fijnvandraat, K. (author), Gevers Leuven, J.A. (author), Peters, M. (author), Kluft, C. (author), Gaubius Instituut TNO (author)Plasma levels of histidine-rich glycoprotein (HRG) were investigated in three groups of women receiving a different dose of estrogens. First, the effect of low-dose estrogen was studied in a group of 83 postmenopausal women who were treated with 0.625 mg conjugated estrogens (CE). No significant change from baseline levels was found at the end...article 1995
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Gevers Leuven, J.A. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)Lipoprotein metabolism is involved in atherogenesis. Female sex-hormones have substantial effects on both lipoprotein metabolism and the vessel wall. Cholesterol, one of the major lipids in lipoproteins, is both the substrate for, and the target of, the steroidal sex hormones.article 1994
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Gevers Leuven, J.A. (author), Havekes, L. (author), van der Kooij-Pontier, H.A. (author), Starmans, R.J.H. (author), Jansen, H. (author), Bouwhuis-Hoogerwerf, M.L. (author), de Pagter, H.A.T. (author), Hessel, L.W. (author), Gaubius Instituut TNO (author)Changes in circulating lipoproteins, which may be related to the risk for atherosclerotic vascular disease, were studied in a control group and in two groups of 24 or 26 women using different preparations of low-dose oral contraceptives for 3 months. One preparation contained 150 μg levo-norgestrel and 30 μg ethinylestradiol (Stediril-d 150/30);...article 1984
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Schreurs, W.H.P. (author), van Rijn, H.J.M. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A study has been made of the serum 25-hydroxycholecalciferol (25-HCC) levels in six groups of women. Significant differences were found between the one pregnant group and the two reference groups as well as between the one pregnant group and two of the three groups using oral contraceptives. No significant differences were found between the...article 1981