Congenital malformations in 4224 children conceived after IVF

Background: The percentage of children born after IVF will continue to increase due to demographic changes such as increasing maternal age and new developments in assisted reproduction techniques. IVF conceptions may carry an increased risk of congenital malformations. Methods: We compared overall and specific congenital malformation rates...

A prospective cohort study on intake of retinol, vitamins C and E and carotenoids and prostate cancer risk (Netherlands)

Objectives: The roles of retinol, vitamins C and E, and carotenoids as risk factors for prostate carcinoma are still questionable. We evaluated these in the Netherlands Cohort Study. Methods: The cohort study consisted of 58,279 men ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 642 incident prostate carcinoma cases were...

Employment in adults with congenital heart disease

Objective: To evaluate job participation, careerrelated problems, and actual job problems in adults with complex congenital heart disease (CHD) compared with adults with mild CHD and reference groups. Design: Cross-sectional study. Setting: Patients were randomly selected from the archives of the Department of Pediatric Cardiology, Leiden...

A prospective study on active and environmental tobacco smoking and bladder cancer risk (The Netherlands)

Objective: In a prospective cohort study among 120,852 adult subjects the authors investigated the associations between cigarette, cigar, pipe, environmental tobacco smoking (ETS), and bladder cancer. Methods: In 1986 all subjects completed a questionnaire on cancer risk factors. Follow-up for incident bladder cancer was established by linkage...

Kinetics of HDL cholesterol and paraoxonase activity in moderate alcohol consumers

Background: The inverse association between moderate drinking and coronary heart disease mortality is well established. This study was performed to investigate the kinetics of the alcohol-induced increases in apo A-1, HDL cholesterol, and paraoxonase (PON) activity, as well as to study whether the alcohol-induced increases in PON activity differ...

Dutch musculoskeletal questionnaire: Description and basic qualities

The article describes the Dutch Musculoskeletal Questionnaire (DMQ) for the analysis of musculoskeletal workload and associated potential hazardous working conditions as well as musculoskeletal symptoms in worker populations. Its qualities are explored using a database of 1,575 workers in various occupations who completed the questionnaire. The...

Costs of different strategies for neonatal hearing screening: A modelling approach

Objective - To compare the cost effectiveness of various strategies for neonatal hearing screening by estimating the cost per hearing impaired child detected. Design - Cost analyses with a simulation model, including a multivariate sensitivity analysis. Comparisons of the cost per child detected were made for: screening method (automated...

Employment work disability and work days lost in patients with ankylosing spondylitis A cross sectional study of Dutch patients

Objective - To evaluate employment status, work disability, and work days lost in patients with ankylosing spondylitis (AS). Methods - A questionnaire was sent to 709 patients with AS aged 16-60. The results of 658 of the patients could be analysed. Results - After adjustment for age, labour force participation was decreased by 15.4% in male...

Work factors and behavioural coping in relation to withdrawal from the labour force in patients with rheumatoid arthritis

Objective - To assess separate and combined effects of work factors and behavioural coping in relation to withdrawal from the labour force among patients with rheumatoid arthritis (RA). Methods - A cross sectional study was conducted in a Dutch nationwide random sample of 720 patients with RA. Information about work factors and behavioural...

The value of salivary bacterial counts as a supplement to past caries experience as caries predictor in children

This study aimed to determine whether salivary mutans streptococci and lactobacilli counts could add any value to a combination of caries experience variables that was recently presented for the prediction of caries. Sixty-nine children at the age of 7.5 yr participated in this longitudinal study. Microbiological data were obtained at the ages...

Vegetable and fruit consumption and lung cancer risk in the Netherlands: Cohort study on diet and cancer

Objective: The purpose was to study the association between vegetable and fruit consumption and lung cancer incidence using 1074 cases after 6.3 years of follow-up in the Netherlands Cohort Study. Methods: Dietary intake was assessed using a 150-item food-frequency questionnaire. Multivariate models were used including age, sex, family history...

Additional risk factors influence excess mortality in heterozygous familial hypercholesterolaemia

Life expectancy of patients with familial hypercholesterolaemia is decreased. Some untreated patients reach a normal life span and, therefore, additional risk factors and the type of mutation in the low-density lipoprotein (LDL) receptor gene are likely to influence the clinical outcome. We determined all cause mortality in kindreds with the...

Differences between men and women in the response of serum cholesterol to dietary changes

Background. Hypercholesterolaemia is initially treated by diet. However, most studies of diet and cholesterol response have been carried out in men, and it is not known whether women react to diet to the same extent as men do. We therefore studied sex differences in the response of serum cholesterol and lipoproteins to diet. Materials and...

Dietary effects on coagulation factor VII vary across genotypes of the R/Q353 polymorphism in elderly people

The objective of this study was to evaluate the association of factor VII with dietary factors while also considering the R/Q353 polymorphism. Nutrition is an important determinant of coagulation factor VII, which is also genetically determined by the R/Q353 polymorphism. High levels of coagulation factor VII clotting activity (FVII:C) are...

Vegetable and fruit consumption and prostate cancer risk: A cohort study in the Netherlands

The association between 21 vegetables and eight fruits and prostate cancer risk was assessed in the Netherlands Cohort Study among 58,279 men of ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 610 cases with complete vegetable data and 642 cases with complete fruit data were available for analysis. In multivariate case-cohort...

Frequentie en determinanten van episiotomie in de tweedelijnsverloskunde in Nederland [Frequency and determinants of episiotomy in Dutch gynaecologist-supervised deliveries]

Objective. To study factors that influence the probability of episiotomy in Dutch gynaecologist-supervised deliveries. Setting. Obstetric units of Dutch hospitals. Design. Observational study. Methods. Data of 65,313 gynaecologist-supervised, vaginal deliveries of live-born singletons registered in the Dutch National Obstetric Database of 1990,...

Fertiliteitsbevorderernde geneesmiddelen en ovariumcatcinoom [Fertility promoting drugs and ovary carcinoma]