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Lüchtenborg, M. (author), Weijenberg, M.P. (author), de Goeij, A.F.P.M. (author), Wark, P.A. (author), Brink, M. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van 't Veer, P. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort...article 2005
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Koushik, A. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Arslan, A.A. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Cerhan, J.R. (author), Colditz, G.A. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Genkinger, J.M. (author), Goldbohm, R.A. (author), Hankinson, S.E. (author), Koenig, K.L. (author), Larsson, S.C. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Patel, A. (author), Rohan, T.E. (author), Schatzkin, A. (author), Smit, E. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Because fruits and vegetables are rich in bioactive compounds with potential cancer-preventive actions, increased consumption may reduce the risk of ovarian cancer. Evidence on the association between fruit and vegetable intake and ovarian cancer risk has not been consistent. We analyzed and pooled the primary data from 12 prospective studies in...article 2005
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Mommers, M. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)BACKGROUND. To the authors' knowledge, only a few prospective studies to date have investigated the correlation between vegetable and fruit consumption and the risk of ovarian carcinoma and their results have been inconclusive. METHODS. Vegetable and fruit intake was assessed in relation to ovarian carcinoma, among 62,573 postmenopausal women...article 2005
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Freudenheim, J.L. (author), Ritz, J. (author), Smith-Warner, S.A. (author), Albanes, D. (author), Bandera, E.V. (author), van den Brandt, P.A. (author), Colditz, G. (author), Feskanich, D. (author), Goldbohm, R.A. (author), Harnack, L. (author), Miller, A.B. (author), Rimm, E. (author), Rohan, T.E. (author), Sellers, T.A. (author), Virtamo, J. (author), Willett, W.C. (author), Hunter, D.J. (author), TNO Kwaliteit van Leven (author)Background: Although smoking is the primary cause of lung cancer, much is unknown about lung cancer etiology, including risk determinants for nonsmokers and modifying factors for smokers. Objective: We hypothesized that alcohol consumption contributes to lung cancer risk. Design: We conducted a pooled analysis using standardized exposure and...article 2005
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TNO Kwaliteit van Leven TNO Voeding (author), Olthof, M.R. (author), van Vliet, T. (author), Verhoef, P. (author), Zock, P.L. (author), Katan, M.B. (author)Background: Betaine (trimethylglycine) lowers plasma homocysteine, a possible risk factor for cardiovascular disease. However, studies in renal patients and in obese individuals who are on a weight-loss diet suggest that betaine supplementation raises blood cholesterol; data in healthy individuals are lacking. Such an effect on cholesterol would...article 2005
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Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Although obesity is an established risk factor for endometrial cancer, evidence linking risk to height, weight change since age 20, and physical activity is limited. In this case-cohort study, 62 573 women from The Netherlands Cohort Study on Diet and Cancer were followed up from 1986 to 1995, and 226 endometrial cancer case patients were...article 2004
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Sierksma, A. (author), Sarkola, T. (author), Eriksson, C.J.P. (author), van der Gaag, M.S. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), TNO Voeding (author)Background: Moderate alcohol consumption is inversely associated with cardiovascular diseases. Changes in hormone levels might in part help explain the positive health effect. This study was performed to examine the effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate (DHEAS), testosterone, and estradiol levels....article 2004
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Männistö, S. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Albanes, D. (author), Anderson, K. (author), van den Brandt, P.A. (author), Cerhan, J.R. (author), Colditz, G. (author), Feskanich, D. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Virtamo, J. (author), Willett, W.C. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Intervention trials with supplemental β-carotene have observed either no effect or a harmful effect on lung cancer risk. Because food composition databases for specific carotenoids have only become available recently, epidemiological evidence relating usual dietary levels of these carotenoids with lung cancer risk is limited. We analyzed the...article 2004
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Brink, M. (author), Weijenberg, M.P. (author), de Goeij, A.F.P.M. (author), Schouten, L.J. (author), Koedijk, F.D.H. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding (author)Associations between dietary intake of various fats and specific K-ras mutations in colorectal cancer (CRC) were investigated within the framework of The Netherlands Cohort Study on diet and cancer (NLCS). After 7.3 years of follow-up and with exclusion of the first 2.3 years, 448 colon and 160 rectal cancer patients and 2948 subcohort members ...article 2004
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Reijneveld, S.A. (author), van der Wal, M.F. (author), Brugman, E. (author), Hira Sing, R.A. (author), Verloove-Vanhorick, S.P. (author)Objective. To estimate the prevalence of parental actions to stop infant crying that may threaten infant health, and to determine specific risk groups regarding these actions. Design. Descriptive. Method. Before their visit to a well-baby clinic in the Netherlands, parents of 3345 infants aged 1-6 months (96.5% response) filled out an anonymous...article 2004
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Dixon, L.B. (author), Balder, H.F. (author), Virtanen, M.J. (author), Rashidkhani, B. (author), Männistö, S. (author), Krogh, V. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Pietinen, P. (author), Tan, F. (author), Virtamo, J. (author), Wolk, A. (author), Goldbohm, R.A. (author), TNO Voeding (author)Background: An analysis of dietary patterns or combinations of foods may provide insight regarding the influence of diet on the risk of colon and rectal cancer. Objective: A primary aim of the Dietary Patterns and Cancer (DIETSCAN) Project was to develop and apply a common methodologic approach to study dietary patterns and cancer in 4 European...article 2004
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Sierksma, A. (author), Muller, M. (author), van der Schouw, Y.T. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), Bots, M.L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between...article 2004
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TNO Preventie en Gezondheid (author), Forsén, L. (author), Sandvig, S. (author), Schuller, A. (author), Søgaard, A.J. (author)Objectives: To investigate compliance with hip protector use. Design: Observational prospective study. Setting: 19 nursing homes (1040 beds). Subjects: All residents during an 18 month period were included in this study. Intervention: Hip protectors were introduced as a regular part of health care service for all residents. Residents at high...article 2004
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TNO Preventie en Gezondheid (author), van den Heuvel, S.G. (author), Ariëns, G.A.M. (author), Boshuizen, H.C. (author), Hoogendoorn, W.E. (author), Bongers, P.M. (author)This study aimed at determining the prognostic factors related to the recurrence of low-back pain and future sickness absence due to low-back pain. Data were used from a prospective cohort study in a working population with a three year follow-up period. They were collected with annual questionnaires. A generalised estimating equation model was...article 2004
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TNO Preventie en Gezondheid (author), Forsén, L. (author), Søgaard, A.J. (author), Sandvig, S. (author), Schuller, A. (author), Røed, U. (author), Arstad, C. (author)Objectives: To compare the probability of hip fracture in protected and unprotected falls in a real world setting in nursing homes. Design: Observational study. Setting: Seventeen nursing homes (965 beds) in Norway. Subjects: All residents in the nursing homes with at least one fall during the intervention period. Intervention: Hip protectors...article 2004
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Proper, K. (author), Hildebrandt, V. (author), van der Beek, A. (author), Green, B.B. (author)Chemicals/CAS: cholesterol, 57-88-5article 2003
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Graafmans, W.C. (author), Lips, P. (author), Wijlhuizen, G.J. (author), Pluijm, S.M. (author), Bouter, L.M. (author)Physical activity is usually considered as an important com0ponent of a healthy lifestyle, including a preventive effect on the risk of falls in the elderly. The relationship between physical activity and falls is complex: physical activity is a prerequisite to maintain neuromuscular functioning, necessary to keep balance and to react to a fall,...article 2003
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Uiterwaal, C.S.P.M. (author), Grobbee, D.E. (author), Sakkers, R.J.B. (author), Helders, P.J.M. (author), Bank, R.A. (author), Engelbert, R.H.H. (author), TNO Preventie en Gezondheid (author)Background. Blood pressure, particularly pulse pressure, is associated with arterial wall stiffness, but little is known about its relation to stiffness of other parts of the body. We examined the extent to which blood pressure levels in young healthy children are related to stiffness of various tissues. Methods. In November 2000, we studied 95...article 2003
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Killestein, J. (author), Hoogervorst, E.L.J. (author), Reif, M. (author), Blauw, B. (author), Smits, M. (author), Uitdehaag, B.M.J. (author), Nagelkerken, L. (author), Polman, C.H. (author), TNO Preventie en Gezondheid (author)Cannabinoids can modulate the function of immune cells. We here present the first human in vivo study measuring immune function in 16 MS patients treated with oral cannabinoids. A modest increase of TNF-α in LPS-stimulated whole blood was found during cannabis plant-extract treatment (p=0.037), with no change in other cytokines. In the subgroup...article 2003
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Reijneveld, S.A. (author), Vogels, A.G.C. (author), Brugman, E. (author), van Ede, J. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author)Background: Psychosocial problems, such as behavioural, emotional, and educational problems, are highly prevalent among children and adolescents. Early treatment may reduce these problems, if accurately identified. Validated questionnaires may support identification. The aim of this study is to assess the psychometric qualities of such a...article 2003