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Austin, P.C. (author), White, I.R. (author), Lee, D.S. (author), van Buuren, S. (author)Missing data is a common occurrence in clinical research. Missing data occurs when the value of the variables of interest are not measured or recorded for all subjects in the sample. Common approaches to addressing the presence of missing data include complete-case analyses, in which subjects with missing data are excluded, or mean-value...article 2021
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Waa, J.V.D. (author), Schoonderwoerd, T. (author), Diggelen, J.V. (author), Neerincx, M. (author)Decision support systems (DSS) have improved significantly but are more complex due to recent advances in Artificial Intelligence. Current XAI methods generate explanations on model behaviour to facilitate a user's understanding, which incites trust in the DSS. However, little focus has been on the development of methods that establish and...article 2020
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Kaskela, A.M. (author), Kotilainen, A.T. (author), Alanen, U. (author), Cooper, R. (author), Green, S. (author), Guinan, J. (author), van Heteren, S. (author), Kihlman, S. (author), van Lancker, V. (author), Stevenson, A. (author)The poor access to data on the marine environment is a handicap to government decision-making, a barrier to scientific understanding and an obstacle to economic growth. In this light, the European Commission initiated the European Marine Observation and Data Network (EMODnet) in 2009 to assemble and disseminate hitherto dispersed marine data. In...article 2019
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Brand, J.P.L. (author), van Buuren, S. (author), le Cessie, S. (author), van den Hout, W.B. (author)In healthcare cost-effectiveness analysis, probability distributions are typically skewed and missing data are frequent. Bootstrap and multiple imputation are well-established resampling methods for handling skewed and missing data. However, it is not clear how these techniques should be combined. This paper addresses combining multiple...article 2019
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Savic, N. (author), Gasic, B. (author), Schinkel, J. (author), Vernez, D. (author)The Advanced REACH Tool (ART) is the most sophisticated tool used for evaluating exposure levels under the European Union's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulations. ART provides estimates at different percentiles of exposure and within different confidence intervals (CIs). However, its performance...article 2018
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- Neerincx, M.A. (author), van der Waa, J. (author), Kaptein, F. (author), van Diggelen, J. (author) conference paper 2018
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van der Waa, J.S. (author), van Diggelen, J. (author), Neerincx, M.A. (author)Explainable AI becomes increasingly important as the use of intelligent systems becomes more widespread in high-risk domains. In these domains it is important that the user knows to which degree the system’s decisions can be trusted. To facilitate this, we present the Intuitive Confidence Measure (ICM): A lazy learning meta-model that can...conference paper 2018
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de Vet, H.C.W. (author), Mullender, M.G. (author), Eekhout, I. (author)Objective: The concept of specific agreement (SA) has been proposed for dichotomous outcomes for two or more raters. We aim to extend this concept for variables with more than two ordinal or nominal categories and more than two raters. Study Design and Setting: We used two data sets: four plastic surgeons classifying photographs after breast...article 2018
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Tromp, P.C. (author), Kuijpers, E. (author), Bekker, C. (author), Godderis, L. (author), Lan, Q. (author), Jedynska, A.D. (author), Vermeulen, R. (author), Pronk, A. (author)To date there is no consensus about the most appropriate analytical method for measuring carbon nanotubes (CNTs), hampering the assessment and limiting the comparison of data. The goal of this study is to develop an approach for the assessment of the level and nature of inhalable multi-wall CNTs (MWCNTs) in an actual workplace setting by...article 2017
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Swamy, M. (author), Shoeibi Omrani, P. (author), González Díez, N. (author)Gas transport in corrugated pipes often exhibit whistling behavior, due to periodic flow-induced pulsations generated in the pipe cavities. These aero-acoustic sources are strongly dependent on the geometrical dimensions and features of the cavities. As a result, uncertainties in the exact shape and geometry play a significant role in...conference paper 2015
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Patlewicz, G. (author), Ball, N. (author), Becker, R.A. (author), Booth, E.D. (author), Cronin, M.T.D. (author), Kroese, D. (author), Steup, D. (author), van Ravenzwaay, B. (author), Hartung, T. (author)Read-across is a data gap filling technique used within category and analogue approaches. It has been utilized as an alternative approach to address information requirements under various past and present regulatory programs such as the OECD High Production Volume Programme as well as the EU's Registration, Evaluation, Authorisation and...article 2014
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- van Dommelen, P. (author), Schönbeck, Y. (author), van Buuren, S. (author) article 2012
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Coenen, P. (author), Kingma, I. (author), Boot, C.R.L. (author), Douwes, M. (author), Bongers, P.M. (author), van Dieën, J.H. (author)Work-related musculoskeletal pain (MSP) risk assessments by trained observers are often used in ergonomic practice; however, the validity may be questionable. We investigated the predictive value of work-site MSP risk estimates in a prospective cohort study of 1745 workers. Trained observers estimated the risk of MSP (neck, shoulder or low-back...article 2012
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Smits, K.M. (author), Schouten, L.J. (author), Hudak, E. (author), Verhage, B. (author), van Dijk, B.A.C. (author), van de Hulsbergen - Kaa, C.A. (author), Goldbohm, R.A. (author), Oosterwijk, E. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Purpose: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which...article 2010
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van Wouwe, J.P. (author), Lanting, C.I. (author), van Dommelen, P. (author), Treffers, P.E. (author), van Buuren, S. (author), TNO Kwaliteit van Leven (author)Aim: The aim of this study was to gain insight into contraception practised and related to breastfeeding duration. Methods: Mothers with infants up to 6 months received a questionnaire on infant feeding (breast or formula feeding) and contraception (hormonal or non-hormonal methods). Estimates of the time interval between resuming contraception...article 2009
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van Buuren, S. (author), Ooms, J.C.L. (author), TNO Kwaliteit van Leven (author)This paper presents a method for calculating stage line diagrams, a novel type of reference diagram useful for tracking developmental processes over time. Potential fields of applications include: dentistry (tooth eruption), oncology (tumor grading, cancer staging), virology (HIV infection and disease staging), psychology (stages of cognitive...article 2009
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Beelen, R. (author), Hoek, G. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Fischer, P. (author), Schouten, L.J. (author), Jerrett, M. (author), Hughes, E. (author), Armstrong, B. (author), Brunekreef, B. (author), TNO Kwaliteit van Leven (author)Background: Several studies have found an effect on mortality of between-city contrasts in long-term exposure to air pollution. The effect of within-city contrasts is still poorly understood. Objectives: We studied the association between long-term exposure to traffic-related air pollution and mortality in a Dutch cohort. Methods: We used data...article 2008
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Rijnders, M. (author), Herschderfer, K. (author), Prins, M. (author), van Baaren, R. (author), van Veelen, A.J. (author), Schönbeck, Y. (author), Buitendijk, S. (author), TNO Kwaliteit van Leven (author)Background: to evaluate the effectiveness of external cephalic version (ECV) without tocolysis or epidural analgesia, the complications associated with the procedure and the association between the number of ECV attempts and cephalic presentation at birth and caesarean section. Methods: retrospective cohort study of all (n = 924) ECVs carried...article 2008
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Preller, L. (author), Balder, H.F. (author), Tielemans, E. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)Objectives: To assess male lung cancer risks for industrial sectors in the Netherlands and to estimate the proportion of lung cancer attributed to working in specific industrial sectors. Methods: Associations were studied among men aged 55-69 years (n = 58 279) from the prospective Netherlands Cohort Study. 1920 incident lung cancer cases were...article 2008
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TNO Kwaliteit van Leven (author), Joling, C.I. (author), Blatter, B.M. (author), Ybema, J.F. (author), Bongers, P.M. (author)Objectives. This study investigated whether work dedication and job resources are longitudinally related to work-related musculoskeletal disorders and whether job resources buffer the impact of job demands on these disorders? Methods. Data were used from a longitudinal three-phase study (2004, 2005, 2006) on health at work among a sample of...article 2008