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Bosland, M.C. (author), Prinsen, M.K. (author), Dirksen, T.J.M. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Carcinomas of the rat prostate induced by a single injection of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, after sequential treatment with cyproterone acetate and testosterone propionate, were evaluated as potential animal model for prostatic cancer. All ten carcinomas examined were located in the...
article 1990
document
Feron, V.J. (author), Bruyntjes, J.P. (author), Woutersen, R.A. (author), Immel, H.R. (author), Appelman, L.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Male Wistar rats were exposed to 0, 10 or 20 ppm formaldehyde vapour for 4, 8 or 13 weeks (6 h/day; 5 days/week), and were then observed for periods up to 126 weeks. Transient growth retardation occurred in both test groups. Death rate was not noticeably affected by formaldehyde. Despite recovery periods of at most 126 weeks, the nasal...
article 1988
document
Beems, R.B. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Chemicals/CAS: benzo[a]pyrene, 50-32-8; retinol, 68-26-8, 82445-97-4; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Vitamin A, 11103-57-4
article 1984
document
Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The effects of etiracetam, a structural analogue or piracetam, were investigated in rats on Y-maze discrimination acquisition, on open field behavior, on one-trial passive avoidance learning and on shuttlebox acquisition and extinction. The results indicate that this drug significantly enhances acquisition and may improve retention without...
article 1981
document
Instituut voor Milieuhygiƫne en Gezondheidstechniek TNO (author), Bossers, P.A. (author)
bookPart 1975
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