Searched for: subject%3A%22Concentration%255C%2B%255C%2528parameters%255C%2529%22
(21 - 40 of 68)
- document
-
Bobeldijk, I. (author), Karlsson, D. (author), Pronk, A. (author), Gonsalves, J. (author), Hekman, M. (author), van de Lagemaat, D. (author), Preller, L. (author), Heederik, D. (author), Skarping, G. (author), TNO Kwaliteit van Leven (author)An adapted method for the quantitative determination of isocyanates in air was implemented and validated in-house. The method was based on air sampling using an impinger flask containing di-n-butylamine (DBA) in toluene and a glass fibre filter in series. The DBA derivatives were determined using liquid chromatography and tandem mass...article 2008
- document
-
van der Grift, B. (author), Griffioen, J. (author), TNO Bouw en Ondergrond (author)Historic emissions from ore smelters typically cause regional soil contamination. We developed a modelling approach to assess the impact of such contamination on groundwater and surface water load, coupling unsaturated zone leaching modelling with 3D groundwater transport modelling. Both historic and predictive modelling were performed, using a...article 2008
- document
-
Rusch, G.M. (author), Bowden, A.M. (author), Muijser, H. (author), Arts, J. (author), TNO Kwaliteit van Leven (author)The objectives of this study were to examine the respiratory irritancy of boron trifluoride (BF3) and fluorosulfonic acid (FSA) following acute inhalation exposure. Testing was conducted using groups of 10 male and 10 female rats (BF3) or groups of 6 male rats (FSA). Rats were exposed for a single 4-h period (BF3) or a single 1-h period (FSA)...article 2008
- document
-
TNO Kwaliteit van Leven (author), Spaan, S. (author), Doekes, G. (author), Heederik, D. (author), Thorne, P.S. (author), Wouters, I.M. (author)The measurement of airborne endotoxins is thus far not standardized. Earlier studies reported higher endotoxin yields when Tween 20 was added to the media used for filter extraction and in the Limulus amebocyte lysate (LAL) assay. This study compared four common media and assessed the effects of Tween during extraction and analysis separately....article 2008
- document
-
Denier van der Gon, H.A.C. (author), Hulskotte, J.H.J. (author), Visschedijk, A.J.H. (author), Schaap, M. (author), TNO Bouw en Ondergrond (author)Comparisons of measured and model-predicted atmospheric copper concentrations show a severe underestimation of the observed concentrations by the models. This underestimation may be (partly) due to underestimated emissions of copper to air. Since the phase out of asbestos brake lining material, the composition of brake lining material has...article 2007
- document
-
Buist, H.E. (author), de Heer, C. (author), van Burgsteden, J.A. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)The in vitro dermal absorption kinetics of didecyldimethylammonium chloride (DDAC) was studied after single and multiple exposure. In addition, the influence of biocidal formulations on the absorption of DDAC was investigated. Following dermal exposure to DDAC in aqueous solution, less than 0.5% of the applied dose reached the receptor fluid...article 2007
- document
-
Vautard, R. (author), Builtjes, P.H.J. (author), Thunis, P. (author), Cuvelier, C. (author), Bedogni, M. (author), Bessagnet, B. (author), Honoré, C. (author), Moussiopoulos, N. (author), Pirovano, G. (author), Schaap, M. (author), Stern, R. (author), Tarrason, L. (author), Wind, P. (author), TNO Bouw en Ondergrond (author)The CityDelta project Cuvelier et al. [2006. CityDelta: a model intercomparison study to explore the impact of emission reductions in European cities in 2010. Atmospheric Environment] is designed to evaluate the air quality response of several emission abatement scenarios for 2010 at the scale of the European continent, and specifically in the...article 2007
- document
-
Wilkinson, S.C. (author), Maas, W.J.M. (author), Nielsen, J.B. (author), Greaves, L.C. (author), van de Sandt, J.J.M. (author), Williams, F.M. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objectives: To determine the effect of skin thickness on the percutaneous penetration and distribution of test compounds with varying physicochemical properties using in vitro systems. Studies were carried out in accordance with OECD guidelines on skin absorption tests. Methods: Percutaneous penetration of caffeine (log P -0.01), testosterone ...article 2006
- document
-
Jeurissen, S.M.F. (author), Bogaards, J.J.P. (author), Boersma, M.G. (author), ter Horst, J.P.F. (author), Awad, H.M. (author), Fiamegos, Y.C. (author), van Beek, T.A. (author), Alink, G.M. (author), Sudhölter, E.J.R. (author), Cnubben, N.H.P. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)In vitro studies were performed to elucidate the human cytochrome P450 enzymes involved in the bioactivation of methyleugenol to its proximate carcinogen 1′-hydroxymethyleugenol. Incubations with Supersomes, expressing individual P450 enzymes to a high level, revealed that P450 1A2, 2A6, 2C9, 2C19, and 2D6 are intrinsically able to 1′...article 2006
- document
-
Arts, J.H.E. (author), Mommers, C. (author), de Heer, C. (author), TNO Kwaliteit van Leven (author)A literature study was performed to evaluate dose-response relationships and no-effect levels for sensitization and elicitation in skin- and respiratory allergy. With respect to the skin, dose-response relationships and no-effect levels were found for both intradermal and topical induction, as well as for intradermal and topical elicitation of...article 2006
- document
-
Schutte, M.E. (author), van de Sandt, J.J.M. (author), Alink, G.M. (author), Groten, J.P. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was...article 2006
- document
-
TNO Kwaliteit van Leven TNO Voeding (author), Ozimek, L.K. (author), Kralj, S. (author), Kaper, T. (author), van der Maarel, M.J.E.C. (author), Dijkhuizen, L. (author)Bacterial fructansucrase enzymes belong to glycoside hydrolase family 68 and catalyze transglycosylation reactions with sucrose, resulting in the synthesis of fructooligosaccharides and/or a fructan polymer. Significant differences in fructansucrase enzyme product specificities can be observed, i.e. in the type of polymer (levan or inulin)...article 2006
- document
-
Hendriks, A.J. (author), Maas-Diepeveen, J.L.M. (author), Heugens, E.H.W. (author), van Straalen, N.M. (author), TNO Kwaliteit van Leven (author)Most of the thousands of substances and species that are of concern for environmental management will not be investigated empirically at ecologically relevant levels because of financial, practical, and ethical constraints. To allow risk assessment for these less well-known categories, we have developed a mechanistic model with classical...article 2005
- document
-
van der Harst, M.R. (author), de Groot, J. (author), Kiers, G.H. (author), Brama, P.A.J. (author), van de Lest, C.H.A. (author), van Weeren, P.R. (author)Objective - To assess whether site-related changes in biochemical composition are present in the cartilage and subchondral and trabecular bone of the metacarpophalangeal joint of horses with early osteoarthritis. Sample population - Right metacarpophalangeal joints from 59 mature warmblood horses. Procedure - Biochemical data (cross-link, amino...article 2005
- document
-
Boonzaaijer, G. (author), Bobeldijk, I. (author), van Osenbruggen, W.A. (author), TNO Kwaliteit van Leven (author)A reliable method for the determination of patulin in apple juice, apple puree and apples was developed using two clean-up steps and high performance liquid chromatography and diode array (HPLC-DAD) analysis. Baseline separation from hydroxymethyl furfural (HMF) was obtained. The performance characteristics of the method were determined at four...article 2005
- document
-
Adams, T.B. (author), Cohen, S.M. (author), Doull, J. (author), Feron, V.J. (author), Goodman, J.I. (author), Marnett, L.J. (author), Munro, I.C. (author), Portoghese, P.S. (author), Smith, R.L. (author), Waddell, W.J. (author), Wagner, B.M. (author), TNO Kwaliteit van Leven (author)This publication is the ninth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the...article 2005
- document
-
de Jong, R.J. (author), Verwei, M. (author), West, C.E. (author), van Vliet, T. (author), Siebelink, E. (author), van den Berg, H. (author), Castenmiller, J.J.M. (author), TNO Kwaliteit van Leven (author)Objective: The aim of this study was to investigate whether milk fortified with folic acid enhances the folate status of humans and whether the presence of folate-binding proteins (FBP) in pasteurised milk affects the bioavailability of folic acid from fortified milk. In untreated and pasteurised milk, folate occurs bound to FBP, while FBP is ...article 2005
- document
-
Hamwijk, C. (author), Schouten, A. (author), Foekema, E.M. (author), Ravensberg, J.C. (author), Collombon, M.T. (author), Schmidt, K. (author), Kugler, M. (author), TNO Bouw en Ondergrond (author)Dichlofluanid (N-dichlorofluoromethylthio-N′-dimethyl-N- phenylsulphamide) is used as booster biocide in antifouling paints. The occurrence of dichlofluanid and its metabolite DMSA (N′-dimethyl-N-phenyl- sulphamide) was monitored in seawater and marine sediment from three Greek marinas. Seawater and sediment samples were collected at three...article 2005
- document
-
van Wendel de Joode, B. (author), Tielemans, E. (author), Vermeulen, R. (author), Wegh, H. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)Charcoal cloth pads have been used to assess volatile chemicals on the skin in a laboratory setting; however, they have not yet been applied to measure dermal exposure in occupational settings. This study aimed at evaluating whether charcoal pads can be used to assess dermal exposure to benzene and toluene in workers of a petrochemical plant....article 2005
- document
-
van Zanden, J.J. (author), de Mul, A. (author), Wortelboer, H.M. (author), Usta, M. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), Cnubben, N.H.P. (author), TNO Kwaliteit van Leven (author)In the present study, the effects of myricetin on either MRP1 or MRP2 mediated vincristine resistance in transfected MDCKII cells were examined. The results obtained show that myricetin can inhibit both MRP1 and MRP2 mediated vincristine efflux in a concentration dependent manner. The IC50 values for cellular vincristine transport inhibition by...article 2005
Searched for: subject%3A%22Concentration%255C%2B%255C%2528parameters%255C%2529%22
(21 - 40 of 68)