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Particle release and control of worker exposure during laboratory-scale synthesis, handling and simulated spills of manufactured nanomaterials in fume hoods

Fonseca, A.S. (author), Kuijpers, E. (author), Kling, K.I. (author), Levin, M. (author), Koivisto, A.J. (author), Nielsen, S.H. (author), Fransman, W. (author), Fedutik, Y. (author), Jensen, K.A. (author), Koponen, I.K. (author)

Fume hoods are one of the most common types of equipment applied to reduce the potential of particle exposure in laboratory environments. A number of previous studies have shown particle release during work with nanomaterials under fume hoods. Here, we assessed laboratory workers’ inhalation exposure during synthesis and handling of CuO, TiO2...

article 2018

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Comparison of industrial emissions and carpet dust concentrations of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in a multi-center U.S. study

Deziel, N.C. (author), Nuckols, J.R. (author), Jones, R.R. (author), Graubard, B.I. (author), de Roos, A.J. (author), Pronk, A. (author), Gourley, C. (author), Colt, J.S. (author), Ward, M.H. (author)

Proximity to facilities emitting polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/F) has been associated with increased risk of non-Hodgkin lymphoma (NHL). There is limited information about whether proximity to industrial sources leads to indoor PCDD/F contamination of homes. We measured carpet dust concentrations (pg/g...

article 2017

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Factors associated with pentosidine accumulation in the human vitreous

Deemter, M.V. (author), Bank, R.A. (author), Vehof, J. (author), Hooymans, J.M.M. (author), Los, L.I. (author)

Purpose: To explore factors associated with pentosidine accumulation in the human vitreous. Methods: Vitreous samples were obtained during trans pars plana vitrectomy for macular hole or rhegmatogenous retinal detachment. Patient characteristics included age, gender, and diabetes mellitus. Ocular characteristics included pseudophakia, posterior...

article 2017

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Factors of concern in a human 3D cellular airway model to aerosols of nanoparticles

Kooter, I.M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Kuper, C.F. (author)

Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors, four exposure modules and four exposure concentrations were varied within four different exposure sessions using a statistical experimental design called a...

article 2017

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A novel safety assessment strategy applied to non-selective extracts

Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)

A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...

article 2015

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Towards an alternative testing strategy for nanomaterials used in nanomedicine: Lessons from NanoTEST

Dusinska, M. (author), Boland, S. (author), Saunders, M. (author), Juillerat-Jeanneret, L. (author), Tran, L. (author), Pojana, G. (author), Marcomini, A. (author), Volkovova, K. (author), Tulinska, J. (author), Knudsen, L.E. (author), Gombau, L. (author), Whelan, M. (author), Collins, A.R. (author), Marano, F. (author), Housiadas, C. (author), Bilanicova, D. (author), Halamoda Kenzaoui, B. (author), Correia Carreira, S. (author), Magdolenova, Z. (author), Fjellsbo, L.M. (author), Huk, A. (author), Handy, R. (author), Walker, L. (author), Barancokova, M. (author), Bartonova, A. (author), Burello, E. (author), Castell, J. (author), Cowie, H. (author), Drlickova, M. (author), Guadagnini, R. (author), Harris, G. (author), Harju, M. (author), Heimstad, E.S. (author), Hurbankova, M. (author), Kazimirova, A. (author), Kovacikova, Z. (author), Kuricova, M. (author), Liskova, A. (author), Milcamps, A. (author), Neubauerova, E. (author), Palosaari, T. (author), Papazafiri, P. (author), Pilou, M. (author), Poulsen, M.S. (author), Ross, B. (author), Runden-Pran, E. (author), Sebekova, K. (author), Staruchova, M. (author), Vallotto, D. (author), Worth, A. (author)

In spite of recent advances in describing the health outcomes of exposure to nanoparticles (NPs), it still remains unclear how exactly NPs interact with their cellular targets. Size, surface, mass, geometry, and composition may all play a beneficial role as well as causing toxicity. Concerns of scientists, politicians and the public about...

article 2015

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Life-cycle assessment framework for indoor emissions of synthetic nanoparticles

Walser, T. (author), Meyer, D. (author), Fransman, W. (author), Buist, H. (author), Kuijpers, E. (author), Brouwer, D. (author)

Life-Cycle Assessment (LCA) is a well-established method to evaluate impacts of chemicals on the environment and human health along the lifespan of products. However, the increasingly produced and applied nanomaterials (defined as one dimension

article 2015

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A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials

Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)

One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...

article 2014

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Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs

Beker van Woudenberg, A. (author), Snel, C. (author), Rijkmans, E. (author), de Groot, D. (author), Bouma, M. (author), Hermsen, S. (author), Piersma, A. (author), Menke, A. (author), Wolterbeek, A. (author)

To improve the predictability of the zebrafish embryotoxicity test (ZET) for developmental (neuro)toxicity screening, we used a multiple-endpoints strategy, including morphology, motor activity (MA), histopathology and kinetics. The model compounds used were antiepileptic drugs (AEDs): valproic acid (VPA), carbamazepine (CBZ), ethosuximide (ETH)...

article 2014

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Effect of moderate alcohol consumption on fetuin-A levels in men and women: Post-hoc analyses of three open-label randomized crossover trials

Joosten, M.M. (author), Schrieks, I.C. (author), Hendriks, H.F.J. (author)

Background: Fetuin-A, a liver-derived glycoprotein that impairs insulin-signalling, has emerged as a biomarker for diabetes risk. Although moderate alcohol consumption has been inversely associated with fetuin-A, data from clinical trials are lacking. Thus, we evaluated whether moderate alcohol consumption decreases circulating levels of fetuin...

article 2014

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Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

Zimmer, B. (author), Pallocca, G. (author), Dreser, N. (author), Foerster, S. (author), Waldmann, T. (author), Westerhout, J. (author), Julien, S. (author), Krause, K.H. (author), van Thriel, C. (author), Hengstler, J.G. (author), Sachinidis, A. (author), Bosgra, S. (author), Leist, M. (author)

Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel alternative tests project, we developed a test battery framework that allows inclusion of any developmental toxicity assay and that explores the responses of such test...

article 2014

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Implementation and evaluation of pH-dependent cloud chemistry and wetdeposition in the chemical transport model REM-Calgrid

Banzhaf, S. (author), Schaap, M. (author), Kerschbaumer, A. (author), Reimer, E. (author), Stern, R. (author), van der Swaluw, E. (author), Builtjes, P. (author)

The Chemistry Transport Model REM-Calgrid (RCG) has been improved by implementing an enhanced description of aqueous-phase chemistry and wet deposition processes including droplet pH. A sensitivity study on cloud and rain droplet pH has been performed to investigate its impact on model sulphate production and gas wet scavenging. Air...

article 2012

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Sea salt concentrations across the European continent

Manders, A.M.M. (author), Schaap, M. (author), Querol, X. (author), Albert, M.F.M.A. (author), Vercauteren, J. (author), Kuhlbusch, T.A.J. (author), Hoogerbrugge, R. (author), TNO Bouw en Ondergrond (author)

The oceans are a major source for particles that play an important role in many atmospheric processes. In Europe sea salt may contribute significantly to particulate matter concentrations. We have compiled sodium concentration data as a tracer for sea salt for 89 sites in Europe to provide more insight in the distribution of sea salt across...

article 2010

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Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure

de Jong, W.H. (author), Arts, J.H.E. (author), de Klerk, A. (author), Schijf, M.A. (author), Ezendam, J. (author), Kuper, C.F. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)

There are currently no validated animal models that can identify low molecular weight (LMW) respiratory sensitizers. The Local Lymph Node Assay (LLNA) is a validated animal model developed to detect contact sensitizers using skin exposure, but all LMW respiratory sensitizers tested so far were also positive in this assay. Discrimination between...

article 2009

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Analyses of human colonic mucus obtained by an in vivo sampling technique

Hamer, H.M. (author), Jonkers, D.M.A.E. (author), Loof, A. (author), van Houtvin, S.A.L.W. (author), Troost, F.J. (author), Venema, K. (author), Kodde, A. (author), Koek, G.H. (author), Schipper, R.G. (author), van Heerde, W.L. (author), Brummer, R.J. (author), TNO Kwaliteit van Leven (author)

Background: The mucus layer is an important dynamic component of the epithelial barrier. It contains mucin glycoproteins and other compounds secreted by the intestinal epithelium, such as secretory IgA. However, a standardized in vivo sampling technique of mucus in humans is not yet available. Aim: To assess the validity and feasibility of mucin...

article 2009

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Preferential campesterol incorporation into various tissues in apolipoprotein E*3-Leiden mice consuming plant sterols or stanols

Plat, J. (author), de Jong, A. (author), Volger, O.L. (author), Princen, H.M.G. (author), Mensink, R.P. (author), TNO Kwaliteit van Leven (author)

Intestinal absorption of plant sterols and stanols is much lower as compared with that of cholesterol; and therefore, serum concentrations are low. Circulating plant sterols and stanols are incorporated into tissues. However, hardly any data are available about tissue distributions of individual plant sterols and stanols, particularly in...

article 2008

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Higher mass loadability in comprehensive two-dimensional gas chromatography-mass spectrometry for improved analytical performance in metabolomics analysis

Koek, M.M. (author), Muilwijk, B. (author), van Stee, L.L.P. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)

article 2008

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Compositional and electric field dependence of the dissociation of charge transfer excitons in alternating polyfluorene copolymer/fullerene blends

Veldman, D. (author), Ipek, Ö. (author), Meskers, S.C.J. (author), Sweelssen, J. (author), Koetse, M.M. (author), Veenstra, S.C. (author), Kroon, J.M. (author), van Bavel, S.S. (author), Loos, J. (author), Janssen, R.A.J. (author), TNO Industrie en Techniek (author)

The electro-optical properties of thin films of electron donor-acceptor blends of a fluorene copolymer (PF10TBT) and a fullerene derivative (PCBM) were studied. Transmission electron microscopy shows that in these films nanocrystalline PCBM clusters are formed at high PCBM content. For all concentrations, a charge transfer (CT) transition is...

article 2008

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Comparison of selection methods to deduce natural background levels for groundwater units

Griffioen, J. (author), Passier, H.F. (author), Klein, J. (author), TNO Bouw en Ondergrond (author)

Establishment of natural background levels (NBL) for groundwater is commonly performed to serve as reference when assessing the contamination status of groundwater units. We compare various selection methods to establish NBLs using groundwater quality data forfour hydrogeologically different areas in the highly populated and developed...

article 2008

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Long-term exposure to traffic-related air pollution and lung cancer risk

Beelen, R. (author), Hoek, G. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Fischer, P. (author), Schouten, L.J. (author), Armstrong, B. (author), Brunekreef, B. (author), TNO Kwaliteit van Leven (author)

Background: Most studies on the association between lung cancer and air pollution have investigated mortality. There have been few studies of lung cancer incidence. Methods: We used data from the ongoing Netherlands Cohort Study on Diet and Cancer for 114,378 subjects with follow-up from September 1986 to December 1997. Exposure to black smoke,...

article 2008