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Eekhout, I. (author), van Buuren, S. (author), Visser, B. (author), Bink, M.C.A.M. (author), Huisman, A. (author)Intensive longitudinal data can be used to explore important associations and patterns between various types of inputs and outcomes. Nonlinear relations and irregular measurement occasions can pose problems to develop an accurate model for these kinds of data. This paper focuses on the development, fitting and evaluation of a prediction model...article 2023
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Groen, E.L. (author), Clark, T.K. (author), Houben, M.M.J. (author), Bos, J.E. (author), Mumaw, R. (author)Background: It is difficult for accident investigators to objectively determine whether spatial disorientation may have contributed to a fatal airplane accident. In this paper, we evaluate three methods to reconstruct the possible occurrence of the somatogravic illusion based on flight data recordings from an airplane accident. (2) Methods: The...article 2022
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de Braaf, B. (author), Rops, C.M. (author), Storm, C. (author)In atomic layer deposition (ALD), thin layers of materials are deposited on a substrate with atomic layer precision in the vertical direction. The ability to control layer growth in the lateral direction as well is expected to greatly increase the potential of ALD as a path to the bottom-up additive fabrication of electronic devices like solar...article 2021
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Iniguez, B. (author), Nathan, A. (author), Kloes, A. (author), Bonnassieux, Y. (author), Romanjek, K. (author), Charbonneau, M. (author), van der Steen, J.L. (author), Gelinck, G.H. (author), Gneiting, T. (author), Mohamed, F. (author), Ghibaudo, G. (author), Cerdeira, A. (author)We review recent compact modeling solutions for Organic and Amorphous Oxide TFTs (OTFTs and AOS TFTs, respectively), which were developed, under the framework of the EU-funded project DOMINO, to address issues specifically connected to the physics of these devices. In particular, using different approaches, analytical equations were formulated...article 2021
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van Bilsen, J.H.M. (author), van den Brink, W. (author), van den Hoek, A.M. (author), Dulos, R. (author), Caspers, M.P.M. (author), Kleeman, R. (author), Wopereis, S. (author), Verschuren, L. (author)Metabolic disorders, such as obesity and type 2 diabetes have a large impact on global health, especially in industrialized countries. Tissue-specific chronic low-grade inflammation is a key contributor to complications in metabolic disorders. To support therapeutic approaches to these complications, it is crucial to gain a deeper understanding...article 2021
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Moné, M.J. (author), Pallocca, G. (author), Escher, S.E. (author), Exner, T. (author), Herzler, M. (author), Hougaard Bennekou, S. (author), Kamp, H. (author), Kroese, E.D. (author), Leist, M. (author), Steger-Hartmann, T. (author), van de Water, B. (author)In 2016, the European Commission launched the EU-ToxRisk research project to develop and promote animal-free approaches in toxicology. The 36 partners of this consortium used in vitro and in silico methods in the context of case studies (CSs). These CSs included both compounds with a highly defined target (e.g. mitochondrial respiratory chain...article 2020
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Langerak, N. (author), Ahmed, H.M.M. (author), Li, Y. (author), Middel, I.R. (author), eslami Amirabadi, H. (author), Malda, J. (author), Masereeuw, R. (author), van Roij, R. (author)Microphysiological systems have potential as test systems in studying the intestinal barrier, in which shear stress is critical for the differentiation of Caco-2 cells into enterocytes. The most commonly used in vitro gut model for intestinal barrier studies is based on trans-well cultures. Albeit useful, these culture systems lack physiological...article 2020
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Westerhout, J. (author), Krone, T. (author), Snippe, A. (author), Babé, L. (author), McClain, S.U. (author), Ladics, G.S. (author), Houben, G.G. (author), Verhoeckx, K.C. (author)Alternative and sustainable protein sources (e.g., algae, duckweed, insects) are required to produce (future) foods. However, introduction of new food sources to the market requires a thorough risk assessment of nutritional, microbial and toxicological risks and potential allergic responses. Yet, the risk assessment of allergenic potential of...article 2019
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de Greeff, J. (author), Hayes, B. (author), Gombolay, M. (author), Johnson, M. (author), Neerincx, M.A. (author), van Diggelen, J. (author), Cefkin, M. (author), Kruijff-Korbayová, I. (author)As robots that share working and living environments with humans proliferate, human-robot teamwork (HRT) is becoming more relevant every day. By necessity, these HRT dynamics develop over time, as HRT can hardly happen only in the moment. What theories, algorithms, tools, computational models and design methodologies enable effective and safe...conference paper 2018
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Remington, B. (author), Broekman, H.C.H. (author), Blom, W.M. (author), Capt, A. (author), Crevel, R.W.R. (author), Dimitrov, I. (author), Faeste, C.K. (author), Fernandez-Canton, R. (author), Giavi, S. (author), Houben, G.F. (author), Glenn, K.C. (author), Madsen, C.B. (author), Kruizinga, A.K. (author), Constable, A. (author)The development and introduction of new dietary protein sources has the potential to improve food supply sustainability. Understanding the potential allergenicity of these new or modified proteins is crucial to ensure protection of public health. Exposure to new proteins may result in de novo sensitization, with or without clinical allergy, or...article 2018
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de Juncker, M.A.M. (author), Huizing, D. (author), del Vecchyo, M.R.O. (author), Phillipson, F. (author), Sangers, A. (author)Problem statements and solution methods in mathematical synchromodal transportation problems depend greatly on a set of model choices for which no rule of thumb exists. In this paper, a framework is introduced with which the model choices in synchromodal transportation problems can be classified, based on literature. This framework should help...conference paper 2017
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Frank Phillipson, F. (author), Ortega del Vecchyo, M. (author), van Ginkel, B. (author), Huizing, S. (author), Sangers, A. (author)In logistic delivery chains time windows are common. An arrival has to be in a certain time interval, at the expense of waiting time or penalties if the time limits are exceeded. This paper looks at the optimal placement of those time intervals in a specific case of a barge visiting two ports in sequence. For the second port a possible delay or...conference paper 2017
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de Huncker, M.A.M. (author), Huizing, D. (author), Ortega del Vecchyo, M.R. (author), Phillipson, F. (author), Sangers, A. (author)Problem statements and solution methods in mathematical synchromodal transportation problems depend greatly on a set of model choices for which no rule of thumb exists. In this paper, a framework is introduced with which the model choices in synchromodal transportation problems can be classified, based on literature. This framework help...conference paper 2017
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van de Steeg, E. (author), Venhorst, J. (author), Jansen, H.T. (author), Nooijen, I.H.G. (author), Degroot, J. (author), Wortelboer, H.M. (author), Vlaming, M.L.H. (author)Human organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 are important hepatic uptake transporters. Early assessment of OATP1B1/1B3-mediated drug-drug interactions (DDIs) is therefore important for successful drug development. A promising approach for early screening and prediction of DDIs is computational modeling. In this study...article 2015
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Wagner, A. (author), Cohen, N. (author), Kelder, T. (author), Amit, U. (author), Liebman, E. (author), Steinberg, D.M. (author), Radonjic, M. (author), Ruppin, E. (author)High-throughput omics have proven invaluable in studying human disease, and yet day-to-day clinical practice still relies on physiological, non-omic markers. The metabolic syndrome, for example, is diagnosed and monitored by blood and urine indices such as blood cholesterol levels. Nevertheless, the association between the molecular and the...article 2015
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Azzopardi, G. (author), Petkov, N. (author)The primate visual system has an impressive ability to generalize and to discriminate between numerous objects and it is robust to many geometrical transformations as well as lighting conditions. The study of the visual system has been an active reasearch field in neuropysiology for more than half a century. The construction of computational...bookPart 2014
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Reimer, R.A. (author), Maathuis, A.J.H. (author), Venema, K. (author), Lyon, M.R. (author), Gahler, R.J. (author), Wood, S. (author)Many of the health benefits associated with dietary fiber are attributed to their fermentation by microbiota and production of short chain fatty acids (SCFA). The aim of this study was to investigate the fermentability of the functional fiber PolyGlyopleX® (PGX®) in vitro. A validated dynamic, computer-controlled in vitro system simulating the...article 2014
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Smit, S.K. (author)Misschien wel de beste oplossing tegen overlast in woonwijken: een computermodel om overlastsituaties te voorspellen. Selmar Smit van TNO ziet reële kansen voor zo’n model. Daarmee kan een wijk overlastbestendig worden ontworpen. Bijvoorbeeld door een buurthuis te bouwen, of een park aanleggen.article 2014
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Erkin, Z. (author), Veugen, T. (author), Toft, T. (author), Lagendijk, R.L. (author)Clustering is a very important tool in data mining and is widely used in on-line services for medical, financial and social environments. The main goal in clustering is to create sets of similar objects in a data set. The data set to be used for clustering can be owned by a single entity, or in some cases, information from different databases is...article 2013
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- Azzopardi, G. (author) doctoral thesis 2013