Searched for: subject:"Colorectal%5C+cancer"
(1 - 20 of 32)

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Heikkila, K. (author), Nyberg, S.T. (author), Madsen, I.E. (author), de Vroome, E. (author), Alfredsson, L. (author), Bjorner, J.B. (author), Borritz, M. (author), Burr, H. (author), Erbel, R. (author), Ferrie, J.E. (author), Fransson, E. (author), Geuskens, G.A. (author), Hooftman, W.E. (author), Houtman, I.L. (author), Jöckel, K.H. (author), Knutsson, A. (author), Koskenvuo, M. (author), Lunau, T. (author), Nielsen, M.L. (author), Nordin, M. (author), Oksanen, T. (author), Pejtersen, J.H. (author), Pentti, J. (author), Shipley, M.J. (author), Steptoe, A. (author), Suominen, S.B. (author), Theorell, T. (author), Vahtera, J. (author), Westerholm, P.J.M. (author), Westerlund, H. (author), Dragano, N. (author), Rugulies, R. (author), Kawachi, I. (author), Batty, G.D. (author), Singh-Manoux, A. (author), Virtanen, M. (author), Kivimäki, M. (author)
Background: Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear. Methods: This multi-cohort study examined the association between working hours and cancer risk in 116 462 men and women who were free of...
article 2016
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Offermans, N.S.M. (author), Vermeulen, R. (author), Burdorf, A. (author), Goldbohm, R.A. (author), Keszei, A.P. (author), Peters, S. (author), Kauppinen, T. (author), Kromhout, H. (author), van den Brandt, P.A. (author)
The evidence for an association between occupational asbestos exposure and esophageal, gastric and colorectal cancer is limited. We studied this association specifically addressing risk differences between relatively low and high exposure, risk associated with cancer subtypes, the influence of potential confounders and the interaction between...
article 2014
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de Vogel, S. (author), Wouters, K.A.D. (author), Gottschalk, R.W.H. (author), van Schooten, F.J. (author), de Goeij, A.F.P.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), van Engeland, M. (author), Weijenberg, M.P. (author)
Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). Among 609 CRC cases and 1,663 subcohort members of the Netherlands Cohort Study on diet and cancer (n = 120,852), we estimated CRC risk according to methyl donor intake across genotypes of folate metabolizing enzymes and methyltransferases....
article 2011
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Bongaerts, B.W.C. (author), de Goeij, A.F.P.M. (author), Wouters, K.A.D. (author), van Engeland, M. (author), Gottschalk, R.W.H. (author), van Schooten, F.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author)
Within the Netherlands Cohort Study (1986), we examined associations between alcohol consumption, the alcohol dehydrogenase 1C (ADH1C) genotype, and risk of colorectal cancer (CRC). After a follow-up period of 7.3 years, 594 CRC cases with information on genotype and baseline alcohol intake were available for analyses. Adjusted incidence rate...
article 2011
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Weijenberg, M.P. (author), Mullie, P.F.F. (author), Brants, H.A.M. (author), Heinen, M.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author), KvL (author)
Since hyperinsulinemia is implicated in the development of colorectal cancer, determinants of serum insulin levels, like the glycemic load and the glycemic index of the diet, could influence cancer risk. Our objective was to evaluate whether a diet with a high glycemic load or glycemic index is associated with increased colorectal cancer risk....
article 2008
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Bongaerts, B.W.C. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)
Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses...
article 2008
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de Vogel, S. (author), Dindore, V. (author), van Engeland, M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)
Adequate intake of folate, methionine, riboflavin, and vitamin B-6 may prevent aberrant DNA methylation and thereby protect against colorectal cancer (CRC). However, previous epidemiological studies investigating associations between dietary intakes of these nutrients and CRC have been inconsistent. We investigated the associations between...
article 2008
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Hogervorst, J.G.F. (author), Schouten, L.J. (author), Konings, E.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Acrylamide is a probable human carcinogen that was detected in several heat-treated foods, such as French fries and crisps, in 2002. Prospective studies are needed on acrylamide and human cancer risk. We prospectively investigated the association between acrylamide and gastrointestinal cancer risk. In 1986, 120,852 men and women (aged 55-69 y)...
article 2008
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Dihal, A.A. (author), van der Woude, H. (author), Hendriksen, P.J.M. (author), Charif, H. (author), Dekker, L.J. (author), IJsselstijn, L. (author), de Boer, V.C.J. (author), Alink, G.M. (author), Burgers, P.C. (author), Rietjens, I.M.C.M. (author), Woutersen, R.A. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author), KvL (author)
Quercetin has been shown to act as an anticarcinogen in experimental colorectal cancer (CRC). The aim of the present study was to characterize transcriptome and proteome changes occurring in the distal colon mucosa of rats supplemented with 10 g quercetin/kg diet for 11 wk. Transcriptome data analyzed with Gene Set Enrichment Analysis showed...
article 2008
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Männistö, S. (author), Yaun, S.S. (author), Hunter, D.J. (author), Spiegelman, D. (author), Adami, H.O. (author), Albanes, D. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Cerhan, J.R. (author), Colditz, G.A. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Harnack, L. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Rohan, T.E. (author), Schatzkin, A. (author), Virtamo, J. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)
Dietary carotenoids have been hypothesized to protect against epithelial cancers. The authors analyzed the associations between intakes of specific carotenoids (alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein + zeaxanthin, and lycopene) and risk of colorectal cancer using the primary data from 11 cohort studies carried out in North...
article 2007
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van den Brandt, P.A. (author), Smits, K.M. (author), Goldbohm, R.A. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)
Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across...
article 2007
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Bongaerts, B.W.C. (author), de Goeij, A.F.P.M. (author), de Vogel, S. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)
High alcohol consumption is related to colorectal cancer (CRC). Our objective was to study associations between alcohol consumption and risk of CRC according to characteristics of aetiological pathways: the chromosomal instability (CIN) and the microsatellite instability (MIN) pathway. We classified CIN+ tumours (tumours with either a truncating...
article 2007
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Dihal, A.A. (author), Tilburgs, C. (author), van Erk, M.J. (author), Rietjens, I.M.C.M. (author), Woutersen, R.A. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)
The aim was to investigate mechanisms contributing to quercetin's previously described effects on cell-proliferation and -differentiation, which contradicted its proposed anticarcinogenic potency. In a 10-day experiment, 40 μM quercetin stabilized by 1 mM ascorbate reduced Caco-2 differentiation up to 50% (p < 0.001). Caco-2 RNA from days 5 and...
article 2007
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van den Brandt, P.A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)
Diet has been hypothesized to play a role in the etiology of gastrointestinal cancer for a long time. Initially, strong evidence of such effects was found in retrospective epidemiological studies. Dietary habits, in particular those from the distant past, are difficult to measure, however. Results from recent, prospective and larger studies of...
article 2006
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de Vogel, S. (author), van Engeland, M. (author), Lüchtenborg, M. (author), de Bruïne, A.P. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)
Folate deficiency has been associated with colorectal cancer risk and may be involved in colorectal carcinogenesis through increased chromosome instability, gene mutations, and aberrant DNA methylation. Within the Netherlands Cohort Study on diet and cancer, we investigated the associations between dietary folate intake and colorectal cancer...
article 2006
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Dihal, A.A. (author), de Boer, V.C.J. (author), van der Woude, H. (author), Tilburgs, C. (author), Bruijntjes, J.P. (author), Alink, G.M. (author), Rietjens, I.M.C.M. (author), Woutersen, R.A. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)
The effect of the flavonoid quercetin and its conjugate rutin was investigated on (biomarkers of) colorectal cancer (CRC). Male F344 rats (n = 42/group) were fed 0, 0.1, 1, or 10 g quercetin/kg diet or 40 g rutin/kg diet. Two wk after initial administration of experimental diets, rats were given 2 weekly subcutaneous injections with 15 mg/kg...
article 2006
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Dihal, A.A. (author), Woutersen, R.A. (author), Ommen, B.v. (author), Rietjens, I.M.C.M. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)
The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001<P<0.05). During differentiation Caco-2 cells formed 5 phase...
article 2006
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Finglas, P.M. (author), de Meer, K. (author), Molloy, A. (author), Verhoef, P. (author), Pietrzik, K. (author), Powers, H.J. (author), van der Straeten, D. (author), Jägerstad, M. (author), Varela-Moreiras, G. (author), van Vliet, T. (author), Havenaar, R. (author), Buttriss, J. (author), Wright, A.J.A. (author), TNO Kwaliteit van Leven (author)
In the past decade, the understanding of folate bioavailability, metabolism and related health issues has increased, but several problems remain, including the difficulty of delivering the available knowledge to the populations at risk. Owing to the low compliance of taking folic acid supplements, for example, among women of child-bearing age...
article 2006
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Balder, H.F. (author), de Vogel, J. (author), Jansen, M.C.J.F. (author), Weijenberg, M.P. (author), van den Brandt, P.A. (author), Westenbrink, S. (author), van der Meer, R.D. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)
Background: The evidence for red meat as a determinant of colorectal cancer remains equivocal, which might be explained by differences in heme content. Heme is the prooxidant, iron-containing porphyrin pigment of meat and its content depends on the type of meat. Chlorophyll from green vegetables might modify this association. Methods: The...
article 2006
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Lüchtenborg, M. (author), Weijenberg, M.P. (author), Kampman, E. (author), van Muijen, G.N. (author), Roemen, G.M.J.M. (author), Zeegers, M.P.A. (author), Goldbohm, R.A. (author), van't Veer, P. (author), de Goeij, A.F.P.M. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
The contribution of cigarette smoking to sporadic colorectal cancer may differ according to molecular aspects of the tumor or according to glutathione S-transferase M1 (GSTM1) or glutathione S-transferase T1 (GSTT1) genotype. In the prospective Netherlands Cohort Study on Diet and Cancer, adjusted incidence rate ratios for 1986-1993 were...
article 2005
Searched for: subject:"Colorectal%5C+cancer"
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